1999 Fiscal Year Final Research Report Summary
Protection Systems in Plant Cells -- A Mechanism of Apoptosis with Monoterpenoids
| Project/Area Number |
10680568
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioorganic chemistry
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| Research Institution | Hiroshima University |
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Principal Investigator |
IZUMI Shunsuke Hiroshima University, Faculty of Science, Associate Professor, 理学部, 助教授 (90203116)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMODA Kei Hiroshima University, Faculty of Science, Research Associate, 理学部, 助手 (40284153)
ASHIDA Yoshiyuki Hiroshima University, Faculty of Science, Research Associate, 理学部, 助手 (40212500)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Plant / Apoptosis / Monoterpenoids / Signal transduction / Active Oxygen / Chemical Stress / Eliciter |
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| Research Abstract |
To investigate the defense mechanism of plant cells against chemical stress, we have screened various isoprenoids for inducers of apoptosis in cultured plant cells such as tabacco, chamomile, celery, soybean, and liverwort. These studies have revealed that geraniol has the most potent apoptosis-inducing activity, as judged from DNA fragmentation in the cells. However, NィイD16ィエD1-(ΔィイD12ィエD1-isopentenyl)adenosine and kinetin prevented the geraniol-induced DNA fragmentation in the cells.
Furthermore, cycloheximide and actinomycin D, inhibitors of protein and RNA syntheses, respectively, did not suppress the apoptosis of the plant cells. This result suggests that the apoptotic process induced by geraniol does not require the synthesis of new proteins.
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Research Products
(8 results)
