1999 Fiscal Year Final Research Report Summary
Analysis of a novel membrane protein during the formation of cortical layers.
| Project/Area Number |
10680742
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neuroscience in general
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| Research Institution | Shinshu University |
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Principal Investigator |
NAKAYAMA Kohzo School of Medicine, Shinshu University, Assistant Professor, 医学部, 講師 (70192680)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Delta / Notch / Preplate / Sub Plate / brain / cortical layers |
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| Research Abstract |
The preplate is composed by earliest generated neuron, including Cajal-Retzius cells and prospected subplate neuron which together play a critical role in the formation of cortical layers. Additionally, Notch and Delta have been identified as key components that mediate the lateral specification and fate of numerous cells during development. Here, we demonstrate that divergent type of Delta (Dll3) is expressed transiently and specifically in a set of earliest generated neuron in neural tube. Moreover, in developing cerebrum, Dll3 is specifically and transiently expressed in prospected subplate neurons. Thus, our results suggest that Dll3 mediates the specification of cell fate in the earliest stage of neurogenesis including neurons compose preplate, leading to the mechanism of genesis of cortical layers
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