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2001 Fiscal Year Final Research Report Summary

Functional link between the superior colliculus and the cerebellum in saccade studied with multiple recording and axonal reconstruction.

Research Project

Project/Area Number 10680761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 神経・脳内生理学
Research InstitutionTOKYO MEDICAL AND DENTAL UNIVERSITY

Principal Investigator

SUGIHARA Izumi  TOKYO MEDICAL AND DENTAL UNIVERSITY, GRADUATE SCHOOL OF MEDICINE AND DENTISTIRY, ASSOCIATE PROFESSOR, 大学院・医歯学総合研究科, 助教授 (60187656)

Project Period (FY) 1998 – 2001
KeywordsINFERIOR OLIVE / CEREBELLUM / BIOTINYLATED DEXTRAN AMIN / CLIMBING FIBER / MOSSY FIBER / CEREBELLAR NUCLEI / RAT / NEUROANATOMY
Research Abstract

Functional link between the superior colliculus and the cerebellum was studied anatomically and electrophysiologically with multiple recording. Significant achievement was attained in anatomical analyzes. It has been already known that the the superior colliculus project to the cerebellum via the climbing fiber system through the inferior olive nucleus. However, projection patterns of the climbing fiber system have not been much clarified. In this study 34 single olivocerebellar axons were reconstructed completely by labeling single axons with biotinylated dextran injected into the inferior olive nucleus of rats. It was clarified that an axon of a single inferior olive neuron ramified to produce about seven climbing fibers, on average, and projects to a longitudinal band-shaped small area in the cerebellar cortex (designated as 'segment') and that most of the olivocerebellar axons had collaterals that projected to small area of the cerebellar nuclei. The neurons in the medial area in the posterior half of the medial accessory olive, which relays the superior colliculus projection to the cerebellum, were found to project to small band-shaped areas in lobule VI and VII of the cerebellar cortex. On the other hand, neighboring lobule I-V and lobule VIII were innervated by neurons in the more lateral areas of the caudal half of the medial accessory olive, presumably concerned with the control of limb movement. We also reconstructed complete trajectories of single mossy fibers, the other main projection system in the cerebellar cortex. Single mossy fibers ramified and spread broadly in the cerebellum, projecting to many longitudinal band-shaped areas. These results would give important informations in understanding function of the cerebellum. Furthermore, these results would help to understand functional micro-compartmentalization of the cerebellum, since it is determined by the connection of input and output fibers of the cerebellum.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Sugihara, I.: "Activation and two modes of blockade by strontium of Ca^<2+>-activated K^+ channels in goldfish saccular hair cells"Journal of General Physiology. 111・2. 363-379 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Lang, E.: "Patterns of spontaneous complex spike activity in the awake rat"Journal of Neuroscience. 19・7. 2728-2739 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wu, H.-S.: "Projection patterns of single mossy fibers originating from the lateral reticular nucleus in the rat cerebellar cortex and nuclei"Journal of Comparative Neurology. 411・1. 97-118 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara, I.: "Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat"Journal of Comparative Neurology. 414・2. 131-148 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara, I.: "Olivocerebellar climbing fibers in the granuloprival cerebellum : morphological study of individual axonal projections in the X-irradiated rat"Journal of Neuroscience. 20・10. 3745-3760 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 杉原 泉: "登上線維系と苔状線維系の単一軸索の投射様式と小脳機能"神経研究の進歩. 44・5. 700-712 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara, I.: "Efferent innervation in the goldfish saccule examined by acetylcholinesterase histochemistry"Hearing Research. 153・1-2. 91-99 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara, I.: "The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to cerebellar compartmentalization"Journal of Neuroscience. 21・19. 7715-7723 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野村恭也: "21世紀耳鼻咽喉科領域の臨床CLIENT21、第8巻、めまい・平衡障害"東京、中山書店. 541 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Gerrits, N.M.: "Cerebellar modules : Molecules, Morphology and Function"Amsterdam, Elsevier Science. 330 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sugihara, I.: "Activation and two modes of blockade by strontium of Ca^<2+>-activated K^+ channels in goldfish saccular hair cells"Journal of General Physiology. 111. 363-379 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Lang, E.: "Patterns of spontaneous complex spike activity in the awake rat"Journal of Neuroscience. 19. 2728-2739 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Wu, H.-S.: "Projection patterns of single mossy fibers originating from the lateral reticular nucleus in the rat cerebellar cortex and nuclei"Journal of Comparative Neurology. 411. 97-118 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara, I.: "Morphology of single olivocerebellar axons labeled with biotinylated dextran amine in the rat"Journal of Comparative Neurology. 414. 131-148 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara, I.: "Olivocerebellar climbing fibers in the granuloprival cerebellum : morphological study of individual axonal projections in the X-irradiated rat"Journal of Neuroscience. 20. 3745-3760 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara, I.: "Cerebellar projection patterns of single axons in climbing and mossy fiber systems and their relation to the cerebellar function"Advances in Neurological Sciences (Shinkeikenkyu no Shimpo). 44. 700-712

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara, I.: "Efferent innervation in the goldfish saccule examined by acetylcholinesterase histochemistry"Hearing Research. 153. 91-99 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sugihara, I.: "The entire trajectories of single olivocerebellar axons in the cerebellar cortex and their contribution to cerebellar compartmentalization"Journal of Neuroscience. 21. 7715-7723 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K Nomura.: "21 Seiki Jibiinkoka Ryoiki no Rinsho. CLIENT 21, Volume 8, Memai Heiko Shougai"Tokyo Nakayama Shoten, (Book in Japanese). 541 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Gerrits, N. M.: "Cerebellar modules : Molecules, Morphology and Function"Amsterdam, Elsevier Science. 330 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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