2000 Fiscal Year Final Research Report Summary
Adaptive Bone Remodeling Under Mechanical Stimuli
| Project/Area Number |
10680790
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TAKAKUDA Kazuo Inst Biomat Bioengng Tokyo Medical and Dental University, Associate Professor, 生体材料工学研究所, 助教授 (70108223)
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| Co-Investigator(Kenkyū-buntansha) |
FUKUDA Hideaki Inst Biomat Bioengng Tokyo Medical and Dental University, Assistant, 生体材料工学研究所, 助手 (50014163)
NAGAI Masahiro Inst Biomat Bioengng Tokyo Medical and Dental University, Assistant, 生体材料工学研究所, 助手 (10013971)
MIYAIRI Hiroo Inst Biomat Bioengng Tokyo Medical and Dental University, Professor, 生体材料工学研究所, 教授 (50013892)
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| Project Period (FY) |
1998 – 2000
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| Keywords | Biomechanics / Bone / Stress / Adaptation / Remodeling |
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| Research Abstract |
Noninvasive three-point bending loads of several distinctive waveforms were applied onto the tibias of young growing rats, and newly formed bones were labeled and observed by light microscopy, The locations of the woven bone formation were shown to be dependent on the waveforms of loads. Examination of the relations between the strains generated by the loads of respective waveforms and the locations of the woven bone formation revealed that the significantly greater amounts of woven bones were formed on the surfaces where dynamic compressive strains were generated.
Furthermore, canine radius after the osteotomy of the ulna was observed by CT image analyses and fluorescence bone labeling. The observation revealed that the new bone was formed not uniformly on the periosterium, but on the periosterium adjacent to the former ulna. This fact suggest those area are under the dynamic compressive strains, and the dynamic compressive strain alone is the effective stimuli for the bone formation.
These dynamic compressive strain specific woven bone formation would give accounts of the adaptive nature of bone remodeling
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