1999 Fiscal Year Final Research Report Summary
Basic Study for Designing Advanced Bio materials Composed of Polypeptide Hybrids
| Project/Area Number |
10680799
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Osaka Prefecture University |
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Principal Investigator |
OKA Masahito Osaka Prefecture University, Research Institute for Advanced Science and Technology, Associate Professor, 先端科学研究所, 助教授 (70203966)
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| Co-Investigator(Kenkyū-buntansha) |
HIRANO Yoshiaki Osaka Institute of Technology, Department of Applied Chemistry, Associate Professor, 工学部, 助教授 (80247874)
HAYASHI Toshio Osaka Prefecture University, Research Institute for Advanced Science and Technology, Professor, 先端科学研究所, 教授 (90026089)
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| Project Period (FY) |
1998 – 1999
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| Keywords | hybrids / polypeptides / conformation / molecular mechanics / peptide synthesis / circular dicroism / helix / bio materials |
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| Research Abstract |
Periodic polypeptides having repetitive amino-acid sequences, which are found in many native periodic proteins such as collagen, were synthesized and their conformations in solutions were analyzed by the CD measurement. It was shown that they take new secondary structures different from well-known α-helix, β-strand and polyproline-II structures. These results were also supported by the theoretical analysis based on the molecular-mechanic calculations. Moreover, many interest results relating to stabilization effects on the specific structures were obtained by the theoretical analysis. As a step of molecular design of polypeptide hybrids, closslinking reactions by γ-ray radiation and synthesis of the polypeptides having vinyl group were tried, then, it was confirmed that the desired products were obtained.
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