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2001 Fiscal Year Final Research Report Summary

Preparation ofmicrocapsule surfaces responding to both of pH and temperature

Research Project

Project/Area Number 10680805
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionTokyo University of Science

Principal Investigator

KUMIKO Makino  Faculty of Pharmaceutical Sciences, Tokyo University of Science, Associate.Professor, 薬学部・製薬学科, 助教授 (40147509)

Co-Investigator(Kenkyū-buntansha) HIROYUKI Ohshima  Faculty of Pharmaceutical Sciences, Tokyo University of Science, Professor, 薬学部・製薬学科, 教授 (60176873)
Project Period (FY) 1998 – 2001
KeywordsPoly (NIPAAm) / Thermosensitivegel / Drug device / Microsphere / Nanosphere / Microcapsule / Protein adsorption / Cell adhesion
Research Abstract

We have prepared thermosensitive hydogel microspheres with various sizes from poly (NIPAAm) which has a phase transition temperature at 33℃. The smaller hydrogel microsphefes showed the higher thermosensitivity, since the hyrogel structure changes depending on its size. We have prepared microcapsules which change their membrane thickness and membrane permeability depending on temperature and pH. The microcapsules have relatively high sensitivity to 2 stimuli, although the hydrogels responding to 2 Stimuli have lower sensitivity than those responding to only one stimulus. This is because the membrane thickness of the microcapsules prepared using the interfacial polymerization method is the order ofnano. We have investigated the interaction of thermsensitive hydrogel surfaces withiproteins or biological cells. The higher amounts of bovine serlim albumin (BSA) was adsorbed on poly (NiPAAm) surfaces at the higher temperatures. The protein molecules once adsorbed oh poly(NiPAAm) surfaces did not desorb by decreasing the temperature. Biological cells adsorb on poly (NIPAAm) hydrogel surfaces above its LCST, and the adsorbed cells were desorbed by decreasing the temperature.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Kimiko Makino., et al.: "Sustained release of hydrophobic materials from sonochemically prepared bovine serum albumin microcapsules"Colloids and Surfaces B : Biointerfaces. 23. 59-64 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino., et al.: "Preparation and properties of thermosensitive hydrogel microcapsules"Colloids and Surfaces B : Biointerfaces. 22. 259-263 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino: "Size-dependent thermosensitivity of Poly (N-isopropylacrylamide-co-acrylic acid) hydrogel microspheres prepared by a membrane emulsification method"J. Oleo Science. 50. 407-413 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] kimiko Makino., et al.: "Dependence of temperature-sensitivity of poly (N-isopropylacrylamide-co-acrylic acid) hydrogel microspheres upon their sizes"Studies in Surface Science and Catalysis. 355-358 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino., et al.: "Aggregation behavior of poly (N-isopropylacrylamide) microspheres"Colloids and Surfaces B : Biointerfaces,. 20. 347-353 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino., et al.: "Sonochemically prepared bovine serum albumin microcapsules : Factors affecting the distribution and the microencapsulation yield"22Colloids and Surfaces B : Biointerfaces. 22. 251-255 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino: "Encyclopedia, Arthur Hubberd Ed., "Thermosensitive Gels""Marcel Dekker, Inc., NY (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimiko Makino, Taro Mizorogi, Shizutoshi Ando, Takeyo Tsukamoto, and Hiroyuki Ohshima: "Sustained release of hydrophobic materials from sonochemically prepared bovine serum albumin microcapsules"Colloids and Surfaces B : Biointerfaces. 23. 59-64 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Yohei Fujita, Ken-ichi Takao, Susumu Kobayashi, and Hiroyuki Ohshima: "Preparation and properties ofthermosensitive hydrogel microcapsules"Colloids and Surfaces B : Biointerfaces. 21. 259-263 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Taro Mizorogi, Shizutoshi Ando, Takeyo Tsukamoto, and Hiroyuki Ohshima: "Sonochemically prepared bovine serum albumin microcapsules : Factors affecting the size distribution and the microencapsulation yield"Colloids and Surfaces B : Biointerfaces. 22. 251-255 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino: "Size-dependent thermosensitivity of poly (N-isopropylacrylamide-co-acrylic acid) hydrogel microspheres prepared by a membrane emulsification method."J.Oleo.Science. 50. 407-413 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino. Hideki Aeata. and Hirovuki Ohshima: "Dependence of temperature-sensitivity of poly (N-isoprppylacrylamid-co-acrylicacid) hydrogel microspheres upon their sizes."Studies in Surface Science and Catalysis. 132. 355-358 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Hitoshi Kado, and Hiroyuki Ohshima: "Aggregation behavior of poly (N-isopropylacrylamide) microspheres."Colloids and Surfaces B : Biointerfaces. 20. 347-353 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Jiro Hiyoshi and Hiiroyuki Ohshima: "Effects ofthermosensitivity of poly (N-isopropylacrylamide) hydrogel upon the duration ofa lag phase at the beginning of the drug release from the hydrogel."Colloids and Surfaces B : Biointerfaces. 20. 341-346 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Hideki Agata, and Biroyuki Ohshima: "Dependence of temperature-sensitivity of poly (N-isoprppylacrylamid(-co-acrylicacid) hydrogel microspheres upon their sizes."J.Colloid Interface Sci.. 230. 128-134 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino, Jiro Hiyoshi, and Hiroyuki Ohshima: "Kinetics of swelling and shrinking of poly (N-isopropylacrylamide) ' hydrogels at different temperatures."Colloids and Surfaces B : Biointerfaces. 19. 197-204 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimiko Makino: ""Thermosensitive Gels""Encyclopedia,Arthur Hubbard Ed. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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