1999 Fiscal Year Final Research Report Summary
Development and Evaluation of a Control Method of total Artificial Heart based on Oxygen Consumption
| Project/Area Number |
10680813
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University (1999)
National Cardiovascular Center Research Institute (1998) |
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Principal Investigator |
NAKAMURA Makoto Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University Associate Professor, 生体材料工学研究所, 助教授 (90301803)
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| Co-Investigator(Kenkyū-buntansha) |
TAENAKA Yoshiyuki National Cardiovascular Center Research Institute Department of Artificial Organs Director, 人工臓器部, 部長 (00142183)
TATSUMI Eisuke National Cardiovascular Center Research Institute Department of Artificial Organs Senior Staff, 人工臓器部, 室長 (00216996)
HONMA Akihiko National Cardiovascular Center Research Institute Department of Artificial Organs Research Associate, 人工臓器部, 室員 (20287428)
MASUZAWA Toru Department of Mechanical Engineering, Ibaraki University Associate Professor, 工学部, 助教授 (40199691)
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| Project Period (FY) |
1998 – 1999
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| Keywords | Total Artificial Heart / Output Control / Oxygen consumption / Mixed Venous Oxygen Saturation / Cardiac Output / Animal Experiment / Normal Animals / Optical Sensor |
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| Research Abstract |
Total artificial heart (TAH) has been developed as one of the most promising optional methods for heart transplantation. Recently, we have been able to evaluate it in in-vivo chronic animal experiments. Physiological control of the TAH is one of the important issues to establish a reliable and effective total artificial heart (TAH) system, especially in in-vivo application TAH output should be controlled just enough to meet the demand of the recipient. In this study, we have developed a TAH control method based on oxygen consumption, which closely and quickly reflects the oxygen and blood flow demand.
The relationship between cardiac output (CO) and mixed venous oxygen saturation (SvO2) and oxygen consumption was investigated in normal calves to establish the TAH control methods. We first developed a control method using SvO2 and evaluate this method in animal experiments using calves implanted with a pneumatic TAH. Compared with the fixed-driving-condition mode, the capacity for exercise was more increased, the hemodynamics and oxygen metabolic parameters were also much better in SvO2-control mode. The results of these experiments indicated the feasibility and validity of this control method using SvO2. Next, we must evaluate a control method using oxygen consumption in vivo, and are now preparing for animal experiments.
The control method of a TAH using oxygen consumption, as well as using SvO2, has many advantages in both physiological and practical areas. The methods and results obtained in this research will contribute to the development of such a safe and reliable TAH system and aid in using a TAH more effectively in clinical applications.
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[Publications] Nakamura M, Homma A, Tatsumi E, Uesho K, Taenaka Y, *Masuzawa T, Nakamura T, Zhang B, Kakuta Y, Imada K, Nakatani T, Takano H: "Mixed venous oxygen saturation as a promising parameter for control of total"ASAIO J. (in press). (2000)
Description
「研究成果報告書概要(欧文)」より
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