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1999 Fiscal Year Final Research Report Summary

The Application of repetitive transcranial magnetic stimulation to the rehabilitation medicine

Research Project

Project/Area Number 10838003
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field リハビリテーション科学
Research InstitutionHOKKAIDO UNIVERSITY

Principal Investigator

MANO Yukio  Hokkaido Univ., School of Med., Pro., 医学部, 教授 (20145882)

Co-Investigator(Kenkyū-buntansha) CHUMA Takayo  Hokkaido Univ., School of Med., Inst., 医学部, 助手 (70281805)
WATANABE Ichiro  Hokkaido Univ., Medical Hospital, Asso. Pro., 医学部・付属病院, 助教授 (50241336)
Project Period (FY) 1998 – 1999
Keywordsrepetitive transcranial magnetic stimulation / ataxia / safety / depression / electroencephalography / parkinsonism
Research Abstract

In 1998, in order to examine the safety of repetitive transcranial magnetic stimulation (rTMS), the behavior of mice was analyed. In 32 normal mice (Crj : ICR) and ataxic mice induced by cytosine arabinoside, rTMS with the intensity of 130% motor threshold were given by 10Hz for 10 sec or 3Hz for 60 sec, 5days a week for 3weeks.
The number of movements and falling ratio were measured by open field method. The number of movements decreased in ataxia group compared with control group significantly (p <0,05). There was no difference in number of movement between with rTMS and without rTMS. The falling ratio of group with rTMS 10Hz for 10 sec decreased significantly more than it of group with rTMS of 3Hz for 60 sec and it of group without rTMS. This could be the effect of rTMS to the cerebellar ataxia.
In 1999, the clinical application of rTMS was tried to 6 patients with parkinsonism or involuntary movement, who were treated by conventional medicine. They showed motor disability and psychological depression.
We used rTMS with 0.3Hz, 110〜120% intensity, 60 times a day, 5 days a week for 2 weeks. One patients showed slow EEG during rTMS so we discontinued the trial of rTMS. 4 patients of 5 showed improvement clinically. The main contents of the improvement were the recovery in mood and depression, but also in some motor disability score.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] 中馬孝容: "平山病の経頭蓋磁気刺激法による検討"神経内科. 49(S1). 198-199 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木村淳: "高頻度磁気刺激法について本法での動物実験の結果の要約"脳波と筋電図. 26(3). 265-267 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中馬孝容: "mirror movementを呈した症例"臨床脳波. 41(10). 678-681 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 眞野行生: "運動神経系の柔軟性とリハビリテーション"脳の科学. 21. 635-641 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 中馬孝容: "パーキンソン病の治療:リハビリテーションの新しい試み"J of Clinical Rehabilitation. 8(11). 1027-1031 (1999)

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      「研究成果報告書概要(和文)」より
  • [Publications] 眞野行生: "MEP(Motor Evoked Potential)"J Clinical Rehab.. 9(3). 268-271 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 眞野行生: "ジストニアの磁気刺激による解析法"Clinical Neuroscience. 17(12). 1308-1309 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mano Yukio: "The effect of repetitive magnetic stimulation on ataxic mice"ELSEVIER, Rrcent Advances in Human Neurophysiology. 969-972 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chuma Takayo: "Magnetic evoked potentials in neck flexion in Hirayama disease"ELSEVIER,Rrcent Advances in Human Neurophysiology. 1014-1017 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chuma Takayo: "The pattern of muscular contraction of biceps brachii elicited by magnetic stimulation"ELSEVIER,Rrcent Advances in Human Neurophysiology. 1018-1021 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chuma Takayo, Mano Yukio: "Magnetic evoked potential in Hirayama disease"Neurological Medicine. 49(S1). 198-199 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kimura Jun, Mano Yukio, et al.: "The summary of animal study of repetitive transcranial magnetic stimulation."EEG & EMG. 26(3). 265-267 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chuma Takayo, Mano Yukio et al.: "Case report of mirror movement"Clinical EEG. 41(10). 678-681 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano Yukio: "The flexibility of motor nervous system and rehabilitation"Brain Science. 21. 635-641 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chuma Takayo, Mano Yukio: "A new trial of the rehabilitation for Parkinson disease"J Clinical Rehab.. 8(11). 1027-1031 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano Yukio, Chuma Takayo: "MEP(Motor Evoked Potential)"J Clinical Rehab.. 9(3). 268-271 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano Yukio, Ikoma Kazunori: "The analysis of dystonia by magnetic stimulation"Clinical Neuroscience. 17(12). 1308-1309 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mano Yukio , Chuma Takayo, et al.: "The effect of repetitive magnetic stimulation on ataxic mice."Recent Advances in Human Neurophysiology, ELSEVIER. 969-972 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chuma Takayo: "Magnetic evoked potentials in neck flexion in Hirayama disease."Recent Advances in Human Neurophysiology, ELSEVIER. 1014-1017 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chuma Takayo, Mano Yukio: "The pattern of muscular contraction of biceps brachii elicited by magnetic stimulation"Recent Advances in Human Neurophysiology, ELSEVIER. 1018-1021 (1998)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2001-10-23  

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