1999 Fiscal Year Final Research Report Summary
Establishment of neurophysiologic classification of the symptomatic epilepsy and molecular pathologic study on the mechanisms of occurrence of epilepsy.
| Project/Area Number |
10839008
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
動物臨床医学
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| Research Institution | Tottori University |
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Principal Investigator |
KAGOTA Katsumoto Faculty of Agriculture, Tottori University, Professor, 農学部, 教授 (80091437)
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| Co-Investigator(Kenkyū-buntansha) |
TAKEUCHI Takashi Faculty of Agriculture, Tottori University, Research Assistant, 農学部, 助手 (20216849)
MORITA Takehito Faculty of Agriculture, Tottori University, Research Assistant, 農学部, 助手 (70273901)
SHIMADA Akinori Faculty of Agriculture, Tottori University, Professor, 農学部, 教授 (20216055)
SATOH Kota Faculty of Agriculture, Tottori University, Research Assistant, 農学部, 助手 (50283974)
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| Project Period (FY) |
1998 – 1999
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| Keywords | electroencephalography / epilepsy / symptomatic / dog |
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| Research Abstract |
A male Maltese dog gradually showed various clinical signs such as inappropriate vocalization, aggression, agitation, circling and generalized seizure at 1-year-old age. A blood biochemistry showed an elevated value of ammonia (51 N-μ g/dl). Electroencephalography (EEG) analysis revealed that epileptic foci were detected in the frontal, parietal, temporal and occipital lobes. A significant glutamate value was found in the cerebrospinal fluid. Computed tomography examination disclosed multiple low density area in the cerebral cortex and white matter. Angiographic analysis disclosed portal-shunt. Histologically, naked astroglial cells were noted throughout the cerebral cortices. Immunohistologically, low expression of glutamine synthetase (GS) comparing to those in the control dogs. GS is a ubiquitous enzyme that catalyzes the ATP-dependent conversion of glutamate (excitatory neurotransmitter) to glutamine using ammonia as the nitrogen source. An abnormal metabolism of glutamate in the brain may be related with superexcitation of neurons.
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