1998 Fiscal Year Annual Research Report

感染免疫の分子基盤の新展開

Research Project

Project/Area Number	10897008
Research Institution	Nagoya University
Principal Investigator	吉開泰信名古屋大学, 医学部, 教授 (90158402)
Co-Investigator(Kenkyū-buntansha)	光山正雄京都大学, 大学院・医学研究科, 教授 (10117260) 姫野國祐徳島大学, 医学部, 教授 (50112339) 中西憲司兵庫医科大学, 教授 (60172350) 清野宏大阪大学, 微生物病研究所, 教授 (10271032) 審良静男兵庫医科大学, 教授 (50192919)
Keywords	感染免疫 / ノックアウトマウス / 自然免疫 / 早期誘導反応 / 後期適応免疫
Research Abstract	重点領域研究「免疫制御、寛容の分子機構」(代表笹月健彦)が平成5年より7年度まで継続され、さらに重点領域研究「免疫病の分子機構とその修復」(代表高津聖志、平成8年度-11年度)が採択され、現在研究計画が着実に遂行されつつある。これらの重点領域研究はわが国の免疫学研究のみならず現代生物学の研究を飛躍的に発展させた。現在の日本の免疫学は世界をリードする牽引的役割をになっており、このことは重点領域研究なくしては語れない。年2回の重点領域研究班会議においては研究成果のみならず、この研究領域の将来展望が討議されている。わが国の言わば熟年期に入った免疫学をさらに発展させるためにはより焦点をしぼり、かつ新しい分野との接点をもつ研究領域の推進の重要性が明確となってきた。一方、細菌学会、ウイルス学会、寄生虫学会では、病原体の種類と感染免疫を含む宿主応答の研究が独自に行われている。。専攻学問分野のそれぞれにおいて、異なる免疫系の構成要素と異なる病原微生物を対象にして感染免疫の研究をおこなっている研究者が平成10年度基盤C(企画調査)によって研究の方向性を検討し、あたらしい免疫学の学問分野への展開となるべく、交流を深めた。専攻学問分野のそれぞれにおいて、異なる免疫系の構成要素や異なる病原微生物を対象にして感染免疫の研究おこなっている研究者を対象として文書によるアンケート調査を実施し、現状の把握すると同時に班会議、シンポジウムを通じて、しぼり込むべき研究の主軸を決定した。感染免疫の分子基盤の確立に中心的研究者となるべき人材の把握が行われた。多様な感染防御機構の構成要素を共通の視点で観るための主軸を決定し、特定領域研究の期間で完成するための準備を行なった。免疫応答の人為的制御による難治性疾患の治療法の実用化へつながることをしぼり込みの対象とした。

Research Products
(20 results)

All Other

All Publications (20 results)

[Publications] Nishimura,H.: "MHC class II-dependent NK1.1^+ γδT cells are induced in mice by Salmonella infection." J.Immunol.162. 1573-1581 (1999)
[Publications] Sakai,T.: "Interleukin 15 activity in the intestinal mucosa of inflammatory bowel disease." Gastroenterology.114. 1237-1243 (1998)
[Publications] Adachi,O.: "Targeted disruption of the MyD88 gene results in loss of IL-1^- and IL-18^- mediated function." Immunity. 9. 143-150 (1998)
[Publications] Akimoto,T.: "Defective NK cell activity and Th1 response in IL-18-deficient mice." Immunity. 9. 143-150 (1998)
[Publications] Yamagiwa,S.: "The primary site of CD4^-8_-B220^+ alpha beta T cells in lpr mice-the appendix in normal mice." J.Immunol.160. 2665-2674 (1998)
[Publications] Inaba,K.: "Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells." J.Exp.Med.188. 2163-2173 (1998)
[Publications] Moritani,M.: "Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic TGF β1." J.Clin.Invest.102. 499-506 (1998)
[Publications] Tsukahara,A.: "Absolute dependence of TCRhi cell generation and relative dependence of TCRint cell generation on the thymus." Eur.J.Immunol.27. 361-367 (1998)
[Publications] VanCott JL: "Regulation of host immune responses by modification of Salmonella virulence genes." Nat.Med.4. 1247-1252 (1998)
[Publications] Ishikawa,H.: "Apoptosis induction by the binding of human immunodeficency virus type 1-gp160 with its carboxyl terminus to calmodulin." J.Virol.72. 6574-6580 (1998)
[Publications] Hamasaki,A.: "Accelerated neutrophil apoptosis in mice lacking Al-a,a subtype of the bcl-2-related Al gene." J.Exp.Med.in press.(1998)
[Publications] Takahashi,Y.: "Human parvovirus B19 as a causative agent for rheumatoid arthritis." Proc.Natl.Acad.Sci.USA. 95. 8227-8232 (1998)
[Publications] Fujii,H.: "Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta-c chain in primary lymphocyte population." EMBO J.17. 6551-6557 (1998)
[Publications] Kmieciak,D.: "The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis." J.Immunol.160. 5676-5683 (1998)
[Publications] Chen YZ: "Modulation of calcium responses by altered peptide ligands in a human T cell clone." Eur J Immunol. 28. 3929-3239 (1998)
[Publications] Mori T: "Involvement of Fas-mediated apoptosis in the hematopoetic progenitor cells of graft-versus-host reaction-associated myelosuppression." Blood. 92. 101-107 (1998)
[Publications] Hisashi Saito: "Generation of intestinal T cells from progenitors residing in gut cryptopatches." Science. 280. 275-278 (1998)
[Publications] Maekawa,K.: "Switch of CD4^+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis." J.Immunol.161. 2120-2127 (1998)
[Publications] Tachibana K.: "The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract." Nature. 393. 591-594 (1998)
[Publications] Ohya,S.: "The contribution of reactive oxygen intermediates and reactive nitrogen intermediates to lsitericidal mechansims differ in macrophages activated pre-and postinfection." Infect Immun. 66. 4043-4049 (1998)

1998 Fiscal Year Annual Research Report

感染免疫の分子基盤の新展開

Principal Investigator

吉開 泰信 名古屋大学, 医学部, 教授 (90158402)

Research Products

[Publications] Nishimura,H.: "MHC class II-dependent NK1.1^+ γδT cells are induced in mice by Salmonella infection." J.Immunol.162. 1573-1581 (1999)

[Publications] Sakai,T.: "Interleukin 15 activity in the intestinal mucosa of inflammatory bowel disease." Gastroenterology.114. 1237-1243 (1998)

[Publications] Adachi,O.: "Targeted disruption of the MyD88 gene results in loss of IL-1^- and IL-18^- mediated function." Immunity. 9. 143-150 (1998)

[Publications] Akimoto,T.: "Defective NK cell activity and Th1 response in IL-18-deficient mice." Immunity. 9. 143-150 (1998)

[Publications] Yamagiwa,S.: "The primary site of CD4^-8_-B220^+ alpha beta T cells in lpr mice-the appendix in normal mice." J.Immunol.160. 2665-2674 (1998)

[Publications] Inaba,K.: "Efficient presentation of phagocytosed cellular fragments on the MHC class II products of dendritic cells." J.Exp.Med.188. 2163-2173 (1998)

[Publications] Moritani,M.: "Abrogation of autoimmune diabetes in nonobese diabetic mice and protection against effector lymphocytes by transgenic TGF β1." J.Clin.Invest.102. 499-506 (1998)

[Publications] Tsukahara,A.: "Absolute dependence of TCRhi cell generation and relative dependence of TCRint cell generation on the thymus." Eur.J.Immunol.27. 361-367 (1998)

[Publications] VanCott JL: "Regulation of host immune responses by modification of Salmonella virulence genes." Nat.Med.4. 1247-1252 (1998)

[Publications] Ishikawa,H.: "Apoptosis induction by the binding of human immunodeficency virus type 1-gp160 with its carboxyl terminus to calmodulin." J.Virol.72. 6574-6580 (1998)

[Publications] Hamasaki,A.: "Accelerated neutrophil apoptosis in mice lacking Al-a,a subtype of the bcl-2-related Al gene." J.Exp.Med.in press.(1998)

[Publications] Takahashi,Y.: "Human parvovirus B19 as a causative agent for rheumatoid arthritis." Proc.Natl.Acad.Sci.USA. 95. 8227-8232 (1998)

[Publications] Fujii,H.: "Functional dissection of the cytoplasmic subregions of the IL-2 receptor beta-c chain in primary lymphocyte population." EMBO J.17. 6551-6557 (1998)

[Publications] Kmieciak,D.: "The effect of deletion of the V3 loop of gp120 on cytotoxic T cell responses and HIV gp120-mediated pathogenesis." J.Immunol.160. 5676-5683 (1998)

[Publications] Chen YZ: "Modulation of calcium responses by altered peptide ligands in a human T cell clone." Eur J Immunol. 28. 3929-3239 (1998)

[Publications] Mori T: "Involvement of Fas-mediated apoptosis in the hematopoetic progenitor cells of graft-versus-host reaction-associated myelosuppression." Blood. 92. 101-107 (1998)

[Publications] Hisashi Saito: "Generation of intestinal T cells from progenitors residing in gut cryptopatches." Science. 280. 275-278 (1998)

[Publications] Maekawa,K.: "Switch of CD4^+ T cell differentiation from Th2 to Th1 by treatment with cathepsin B inhibitor in experimental leishmaniasis." J.Immunol.161. 2120-2127 (1998)

[Publications] Tachibana K.: "The chemokine receptor CXCR4 is essential for vascularization of the gastrointestinal tract." Nature. 393. 591-594 (1998)

[Publications] Ohya,S.: "The contribution of reactive oxygen intermediates and reactive nitrogen intermediates to lsitericidal mechansims differ in macrophages activated pre-and postinfection." Infect Immun. 66. 4043-4049 (1998)

吉開泰信名古屋大学, 医学部, 教授 (90158402)