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2002 Fiscal Year Final Research Report Summary

Molecular Medicine of Neurodegenerative Disease and Malignant Tumor

Research Project

Project/Area Number 10CE2006
Research Category

Grant-in-Aid for COE Research

Allocation TypeSingle-year Grants
Research InstitutionNagoya University

Principal Investigator

TAKAHASHI Masahide  Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (40183446)

Co-Investigator(Kenkyū-buntansha) FURUKAWA Koichi  Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (80211530)
SOBUE Gen  Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (20148315)
MURAMATSU Takashi  Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (00030891)
HAMAGUCHI Michinari  Graduate School of Medicine, Professor, 大学院・医学系研究科, 教授 (90135351)
Project Period (FY) 1998 – 2002
KeywordsNeurodegenerative disease / Malignant tumor / RET gene / Midkine / Dorfin gene / Ganglioside / Cancer invasion / Transgenic mouse
Research Abstract

1. To investigate the role of tyrosine 1062 in RET in neuronal differentiation, we produced knock-in mice in which tyrosine 1062 was replaced with phenylalanine. Differentiation of enteric neurons in the whole intestinal tract was severely impaired in mice, indicating that the intracellular signaling via tyrosine 1062 plays an important role in the development of the enteric nervous system.
2. The midkine (MK) receptor is thought to be a molecular complex of protepglycans including protein tyrosine phosphatase ζ (PTPζ) and syndecan. MK binds to the chondroitin sulfate portion of PTPζ, especially to the E unit that has 4,6-disulfated N-acetylgalactosamine, with high affinity. The binding of MK to syodecan was mediated by the trisulfated structure of N- and 6-O-sulfated glucosamine and 2-sulfated uronic acid.
3. Dorfin, a RING finger-type E3 ubiquitin ligase, is predominantly localized in the inclusion bodies of familial ALS with a copper/zinc superoxide dismutase (SOD1) mutation as well a … More s sporadic ALS. Dorphin physiologically bound and ubiquitylated various SOD1 mutants derived from familial ALS patients and enhanced their degradation. The overexpression of Dorfin protected against the toxic effects of mutant SOD1 on neural cells and reduced SOD1 inclusions.
4. Double knock-out mice lacking the GM2/GD2 and the GD3 synthase gene were generated by mating single gene mutants. We observed a refractory skin lesion that appeared on the face of mutant mice at 25 weeks after birth or later. Characteristic proliferation of nerve fibers was found in the epidermis and subepidermis at the injured sites, probably a result of continuous skin injury. Peripheral nerve degeneration was observed in young mutant mice, suggesting that reduced sensory function induced over-scratching.
5. Treatment of QG90 human lung cancer cells with hyaluronan (HA) strongly activated MMP-2 secretion and expression of antisense CD44s in QG90 cells inhibited the HA-dependent secretion of MMP-2. We found that HA-CD44 signaling plays a key role in the HA-dependent secretion of MMP-2 and, hence, in the invasiveness of QG90 cells. Less

  • Research Products

    (94 results)

All Other

All Publications (94 results)

  • [Publications] Nozaki, C.et al.: "Calcium-dependent Ret activation by GDNF and neurturin"Oncogene. 16. 293-299 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li, M.et al.: "Nuclear Inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy"Ann.Neurol.. 44. 249-254 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takamiya, K.et al.: "Complex gangliosides are essential in spermatogenesis of mice : Possible roles in the transport of testosterone"Proc.Natl.Acad.Sci.USA. 95. 12147-12152 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shibata, K.et al.: "Both focal adhesion kinase and c-Ras are required for the enhanced Matrix Metalloproteinase-9(MMP-9) secretion by fibronectin in the ovarian cancer"Cancer Res.. 58. 900-903 (1998)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, M.et al.: "Co-segregation of MEN2 and Hirschsprung's disease : the same mutation of RET with both gain and loss-of-function?"Hum.Mutat.. 13. 331-336 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohyabu, A.et al.: "Genetic mapping of the thymoma susceptible locus, Tsr1, in BUF/Mna rats"J.Natl.Cancer I.. 91. 279-282 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda, N.et al.: "A receptor-like protein -tyrosine phosphatase PTPζ/ RPTPβ binds a heparin-binding a growth factor midkine"J.Biol.Chem.. 274. 12474-12479 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sato, T.et al.: "Transgenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG"Hum.Mol.Genet.. 8. 99-106 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukumoto, S.et al.: "Expression cloning of mouse cDNA of CMP-NeuAc : lactosylceramide a2,3-sialyltransferase (GM3 synthase), an enzyme"J.Biol.Chem.. 274. 9271-9276 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Thant, A.A.et al.: "Ras Pathway is required for the activation of MMP-2 and for the invasion of src-transformed 3Y1"Oncogene. 18. 6555-6563 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kawai, K.et al.: "Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation"Cancer Res.. 60. 5254-5260 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shimono, Y.et al.: "RFP is a transcriptional repressor and interacts with enhancer of polycomb that has dual transcriptional functions"J.Biol.Chem.. 275. 39411-39419 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Horiba, M.et al.: "Neointima formation in a restenosis model is suppressed in midkine-deficient mice"J.Clin.Invest.. 105. 489-495 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kobayashi, Y.et al.: "Chaperones, Hsp70 and Hsp40, suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein"J.Biol.Chem.. 275. 8772-8778 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukumoto, S.et al.: "GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation"J.Biol.Chem.. 275. 5832-5838 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa, K.et al.: "Molecular basis for the p phenotype : Identification of distinct and multiple mutations in the α1,4-galactosyltransferase gene in Swedish and Japanese"J.Biol.Chem.. 275. 37752-37756 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsuda, S.et al.: "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer"Cancer Res.. 60. 13-17 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwashita, T.et al.: "Functional analysis of RET with Hirschsprung's mutations affecting its kinase domain"Gastroenterology. 121. 24-33 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takahashi, M.: "The GDNF/RET signaling pathway and human diseases"Cytokine & Growth Factor Reviews. 12. 361-373 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei, Y.et al.: "Antisense oligodeoxynucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells"Cancer Res. 61. 8486-8491 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshida, S.et al.: "Ganglioside GD2 in small cell lung cancer cell lines : Enhancement of cell proliferation and mediation of apoptosis"Cancer Res.. 61. 4244-4252 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Liu, Y.et al.: "Suppression of cell spreading by v-Crk requires Ras-MEK-MAP kinase signaling"Oncogene. 20. 5908-5912 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayashi, K et al.: "Invasion activating caveolin-1 mutation in human scirrhous breast cancers"Cancer Res.. 61. 2361-2354 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukuda T.et al.: "Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase"J.Biol.Chem.. 277. 19114-19121 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe T., et al.: "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation"Am.J.Pathol.. 161. 249-256 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato M.et al.: "Repair by Src kinase of functional-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines"Cancer Res.. 62. 2414-2422 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Murakami H.et al.: "Role of Dok1 in cell signaling mediated by RET tyrosine kinase"J.Biol.Chem.. 277. 32781-32790 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakayama A.et al.: "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter"J.Biol.Chem.. 278. 233-240 (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Uchimura K.et al.: "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression"J.Biol.Chem.. 277. 3979-3984 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takei Y.et al.: "5'-,3'-Inverted-thymidine-modified antisense oligodeoxynuclediotide targeting midkine : its application for cancer therapy"J.Biol.Chem.. 277. 23800-23806 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sumi Y.et al.: "Midkine, a heparin-binding growth factor promotes growth and glycosaminoglycan synthesis of endothelial cells through its action"J.Cell Sci.. 115. 2659-2667 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shibata Y.et al.: "Nuclear targeting by the growth factor midkine"Mol.Cell.Biol.. 22. 6788-6796 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Muramatsu, T.: "Midkine and pleiotrophin : two related proteins involved in development, survival, inflammation and tumorigenesis"J.Biochem.. 132. 359-371 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ishigaki S.et al.: "X-linked inhibitor of apoptosis protein is involved in mutant SOD-1 mediated neuronal degeneration"J.Neurochem.. 82. 576-584 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsuno, M.et al.: "Teststerone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy"Neuron. 35. 843-854 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Niwa J.et al.: "Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity"J.Biol.Chem.. 277. 36793-36798 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takeuchi, H.et al.: "Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-depenent cell death in a cellular model of familial amyotrophic"J.Biol.Chem.. 277. 50966-50972 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Adachi, H.et al.: "HSP70 chaperone over expression ameliorates phenotypes of the SBMA transgenic mouse model by reducing nuclear-localized mutant AR protein"J.Neurosci.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Mitsuda, T.et al.: "Over-expression of ganglioside GM1 results in the dispersion of platelet derived growth factor receptor from glycolipid-enriched microdomains"J.Biol.Chem.. 277. 11239-11246 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Furukawa, K.et al.: "Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells : implication in the sensitivity to verotoxins"J.Biol.Chem.. 277. 11247-11254 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue, M.et al.: "Refractory skin injury in the complex knock-out mice expressing only GM3 ganglioside"J.Biol.Chem.. 277. 29881-29888 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Okada, M.et al.: "b-series ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apotosis"J.Biol.Chem.. 277. 1633-1636 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tsuchida, A.et al.: "Synthesis of disialyl Lewis a structure in colon cancer cell lines by a sialyltransferase ST6GalNAc VI responsible for the synthesis of α-series"J.Biol.Chem.. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Itano N.et al.: "Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration"Proc.Natl.Acad.Sci.USA. 99. 3609-3614 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ichigotani Y.et al.: "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells"Cancer Res.. 62. 2215-2219 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Zhang Y.et al.: "Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human lung carcinoma cell line QG90"Cancer Res.. 62. 3962-3965 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Oshima K.et al.: "SHPS-1 : a budding molecule against cancer dissemination"Cancer Res.. 62. 3929-3933 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nozaki, C. et al.: "Calcium-dependent Ret activation by GDNF and neurturin"Oncogene. 16. 293-299 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li, M. et al.: "Nuclear Inclusions of the androgen receptor protein in spinal and bulbar muscular atrophy"Ann. Neurol. 44. 249-254 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takamiya, K. et al.: "Complex gangliosides are essential in spermatogenesis of mice : Possible roles in the transport of testosterone"Proc. Natl. Acad. Sci. USA. 95. 12147-12152 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibata, K. et al.: "Both focal adhesion kinase and c-Ras are required for the enhanced Matrix Metalloproteinase-9 (MMP-9) secretion by fibronectin in the ovarian cancercells"Cancer Res.. 58. 900-903 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, M. et al.: "Co-segregation of MEN2 and Hirschsprung's disease : the same mutation of RET with both gain and loss-of-function?"Hum. Mutat.. 13. 331-336 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohyabu, A. et al.: "Genetic mapping of the thymoma susceptible locus, Tsr1, in BUF/Mna rats"J. Natl. Cancer I. 91. 279-282 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Maeda, N. et al.: "A receptor-like protein -tyrosine phosphatase PTP ζ / RPTP β binds a heparin- binding growth factor midkine. Involvement of arginine 78 of midkine in the high affinity binding to PTP ζ"J. Biol. Chem. 274. 12474-12479 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sato, T. et al.: "Transjenic mice harboring a full-length human mutant DRPLA gene exhibit age-dependent intergenerational and somatic instabilities of CAG repeats comparable with those in DRPLA patients"Hum. Mol. Genet.. 8. 99-106 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukumoto, S. et al.: "Expression cloning of mouse cDNA of CMP-NeuAc : lactosylceramide a2,3-sialyltransferase (GM3 synthase), an enzyme that initiates the synthesis of gangliosides"J. Biol. Chem.. 274. 9271-9276 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Thant, A. A. et al.: "Ras pathway is required for the activation of MMP-2 and for the invasion of src-transformed 3Y1"Oncogene. 18. 6555-6563 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kawai, K. et al.: "Tissue-specific carcinogenesis in transgenic mice expressing the RET proto-oncogene with a multiple endocrine neoplasia type 2A mutation"Cancer Res.. 60. 5254-5260 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shimono, Y. et al.: "RFP is a transcriptional represser and interacts with enhancer of polycomb that has dual transcriptional functions"J. Biol. Chem.. 275. 39411-39419 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Horiba, M. et al.: "Neointima formation in a restenosis model is suppressed in midkine-deficient mice"J. Clin. Invest.. 105. 489-495 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi, Y. et al.: "Chaperones, Hsp7O and Hsp40, suppress aggregate formation and apoptosis in cultured neuronal cells expressing truncated androgen receptor protein with expanded polyglutamine tract"J. Biol. Chem.. 275(12). 8772-8778 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukumoto, S. et al.: "GD3 synthase gene expression in PC12 cells results in the continuous activation of TrkA and ERK1/2 and enhanced proliferation"J. Biol. Chem.. 275. 5832-5838 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, K. et al.: "Molecular basis for the p phenotype : Identification of distinct and multiple mutations in the α1,4-galactosyltransferase gene in Swedish and Japanese individuals"J. Biol. Chem.. 275. 37752-37756 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsuda, S. et al.: "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer"Cancer Res.. 60. 13-17 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwashita, T. et al.: "Functional analysis of RET with Hirschsprung's mutations affecting its kinase domain"Gastroenterlogy. 121. 24-33 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takahashi, M.: "The GDNF/RET signaling pathway and human diseases"Cytokene & Growth Factor Reviews. 12. 361-373 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y. et al.: "Antisense oligodeoxynucleotide targeted to midkine, a heparin-binding growth factor, suppresses tumorigenicity of mouse rectal carcinoma cells"Cancer Res.. 61. 8486-8491 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida, S. et al.: "Ganglioside GD2 in small cell lung cancer cell lines : Enhancement of cell proliferation and mediation of apoptosis"Cancer Res.. 61. 4244-4252 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Liu, Y. et al.: "Suppression of cell spreading by v-Crk requires Ras-MEK-MAP kinase signaling"Oncogene. 20. 5908-5912 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi, K et al.: "Invasion activating caveolin-1 mutation in human scirrhous breast cancers"Cancer Res.. 61. 2361-2364 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukuda, T. et al.: "Novel mechanism of regulation of Rac activity and lamellipodia formation by RET tyrosine kinase"J. Biol. Chem.. 277. 19114-19121 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe, T. et al.: "Characterization of gene expression induced by RET with MEN2A or MEN2B mutation"Am. J. Pathol.. 161. 249-256 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato, M. et al.: "Repair by Src kinase of functional-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine"Cancer Res.. 62. 2414-2422 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Murakami, H. et al.: "Role of Dok1 in cell signaling mediated by RET tyrosine kinase"J. Biol. Chem.. 277. 32781-32790 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakayama, A. et al.: "Role for RFX transcription factors in non-neuronal cell-specific inactivation of the microtubule-associated protein MAP1A promoter"J. Biol. Chem.. 278. 233-240 (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Uchimura, K. et al.: "Specificities of N-acetylglucosamine-6-O-sulfotransferases in relation to L-selectin ligand synthesis and tumor-associated enzyme expression"J. Biol. Chem.. 277. 3979-3984 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takei, Y. et al.: "5'-, 3 '-Inverted-thymidine-modified antisense oligodeoxynuclediotide targeting midkine : its application for cancer therapy"J. Biol. Chem. 277. 23800-23806 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sumi, Y. et al.: "Midkine, a heparin-binding growth factor promotes growth and glycosaminoglycan synthesis of endothelial cells through its action on smooth muscle cells in an artificial blood vessel model"J. Cell Sci.. 115. 2659-2667 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shibata, Y. et al.: "Nuclear targeting by the growth factor midkine"Mol. Cell. Biol.. 22. 6788-6796 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Muramatsu, T.: "Midkine and pleiotrophin : two related proteins involved in development, survival, inflammation and tumorigenesis"J. Biochem.. 132. 359-371 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ishigaki, S. et al.: "X-linked inhibitor of apoptosis protein is involved in mutant SOD-1 mediated neuronal degeneration"J. Neurochem.. 82. 576-584 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsuno, M. et al.: "Teststerone reduction prevents phenotypic expression in a transgenic mouse model of spinal and bulbar muscular atrophy"Neuron.. 35. 843-854 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Niwa, J. et al.: "Dorfin ubiquitylates mutant SOD1 and prevents mutant SOD1-mediated neurotoxicity"J. Biol. Chem.. 277. 36793-36798 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takeuchi, H. et al.: "Mitochondrial localization of mutant superoxide dismutase 1 triggers caspase-depenent cell death in a cellular model of familial amyotrophic lateral sclerosis"J. Biol. Chem.. 277. 50966-50972 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Adachi, H. et al.: "HSP70 chaperone over-expression ameliorates phenotypes of the SBMA transgenic mouse model by reducing nuclear-localized mutant AR protein"J. Neurosci.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Mitsuda, T. et al.: "Over-expression of ganglioside GM1 results in the dispersion of platelet derived growth factor receptor from glycolipid-enriched microdomains and in the suppression of cell growth signals"J. Biol. Chem.. 277. 11239-11246 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Furukawa, K. et al.: "Expression of the Gb3/CD77 synthase gene in megakaryoblastic leukemia cells : implication in the sensitivity to verotoxins"J. Biol. Chem.. 277. 11247-11254 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, M. et al.: "Refractory skin injury in the complex knock-out mice expressing only GM3 ganglioside"J. Biol. Chem.. 277. 29881-29888 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Okada, M. et al.: "b-series ganglioside deficiency exhibits no definite changes in the neurogenesis and the sensitivity to Fas-mediated apotosis, but impairs regeneration of the lesioned hypoglossal nerve"J. Biol. Chem.. 277. 1633-1636 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tsuchida, A, et al.: "Synthesis of disialyl Lewis a structure in colon cancer cell lines by a sialyltransferase ST6GaINAc VI responsible for the synthesis of α-series gangliosides"J. Biol. Chem.. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Itano, N. et al.: "Abnormal accumulation of hyaluronan matrix diminishes contact inhibition of cell growth and promotes cell migration"Proc. Natl. Acad. Sci. USA. 99. 3609-3614 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ichigotani, Y. et al.: "Forced expression of NESH suppresses motility and metastatic dissemination of malignant cells"Cancer Res.. 62. 2215-2219 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Zhang, Y. et al.: "Hyaluronan-CD44s signaling regulates matrix metalloproteinase-2 secretion in a human, lung carcinoma cell line QG90"Cancer Res.. 62. 3962-3965 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Oshirna, K. et al.: "SHPS-1 : a budding molecule against cancer dissemination"Cancer Res.. 62. 3923-3933 (2002)

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Published: 2004-04-14  

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