2000 Fiscal Year Final Research Report Summary
ELUCIDATION OF HEPATOCARINOGENESIS IN HEPATITIS C VIRUS INFECTION USING TRANSGENIC MICE.
| Project/Area Number |
11138213
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas (A)
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| Allocation Type | Single-year Grants |
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| Research Institution | The University of Tokyo |
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Principal Investigator |
KOIKE Kazuhiko TOKYO UNIV., DPT OF MEDICINE, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (80240703)
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| Co-Investigator(Kenkyū-buntansha) |
FUJIE Hajime TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
SHINTANI Yoshizumi TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
MORIYA Kyoji TOKYO UNIV., DPT OF MEDICINE, ASSISTANT PROFESSOR, 医学部・附属病院, 助手
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| Project Period (FY) |
1999 – 2000
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| Keywords | hepatitis C virus / transgenic mice / core protein / hepatocellular carcinoma / hepatitis / steatosis |
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| Research Abstract |
Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide, which finally leads to the development of hepatocellular carcinoma (HCC). However, the mechanism of hepatocarcinogenesis in chronic HCV infection is still unclear. The ability of the core protein of HCV to modulate intracellular signaling pathways has been suggested as being involved in the pathogenesis of HCC.Here we describe the development of HCC in HCV core gene transgenic mice which develop hepatic steatosis early in life as a histological feature characteristic of chronic hepatitis C.The feature in the development of HCC in these mice closely resembled the histopathological characteristics previously observed in the early stage of HCC in patients with chronic hepatitis C.These results indicate that the HCV core protein has a major role in the development of HCC and that HCV itself is directly involved in hepatocarcinogenesis.
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[Publications] H.Fujie, H.Yotsuyanagi, K.Moriya, Y.Shintani, T.Tsutsumi, T.Takayama, M.Makuuchi, Y.Matsuura, T.Miyamura, S.Kimura, K.Koike.: "Steatosis and Intrahepatic hepatitis C virus in chronic hepatitis."J Med Virol. 59. 141-145 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] H.Yotsuyanagi, Y.Shintani, K.Moriya, H.Fujie, T.Tsutsumi, T.Kato, K.Nishioka, T.Takayama, M.Makuuchi, S.Iino, S.Kimura, K.Koike.: "Virological analysis of "non-B, non-C" hepatocellular carcinoma in Japan : frequent involvement of hepatitis B virus.."J Infect Dis. (in press). (2000)
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「研究成果報告書概要(欧文)」より
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