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2000 Fiscal Year Final Research Report Summary

ELUCIDATION OF HEPATOCARINOGENESIS IN HEPATITIS C VIRUS INFECTION USING TRANSGENIC MICE.

Research Project

Project/Area Number 11138213
Research Category

Grant-in-Aid for Scientific Research on Priority Areas (A)

Allocation TypeSingle-year Grants
Research InstitutionThe University of Tokyo

Principal Investigator

KOIKE Kazuhiko  TOKYO UNIV., DPT OF MEDICINE, ASSOCIATE PROFESSOR, 医学部・附属病院, 助教授 (80240703)

Co-Investigator(Kenkyū-buntansha) FUJIE Hajime  TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
SHINTANI Yoshizumi  TOKYO UNIV., DPT OF MEDICINE, MEDICAL STUFF, 医学部・附属病院, 医員
MORIYA Kyoji  TOKYO UNIV., DPT OF MEDICINE, ASSISTANT PROFESSOR, 医学部・附属病院, 助手
Project Period (FY) 1999 – 2000
Keywordshepatitis C virus / transgenic mice / core protein / hepatocellular carcinoma / hepatitis / steatosis
Research Abstract

Hepatitis C virus (HCV) is the major cause of chronic hepatitis worldwide, which finally leads to the development of hepatocellular carcinoma (HCC). However, the mechanism of hepatocarcinogenesis in chronic HCV infection is still unclear. The ability of the core protein of HCV to modulate intracellular signaling pathways has been suggested as being involved in the pathogenesis of HCC.Here we describe the development of HCC in HCV core gene transgenic mice which develop hepatic steatosis early in life as a histological feature characteristic of chronic hepatitis C.The feature in the development of HCC in these mice closely resembled the histopathological characteristics previously observed in the early stage of HCC in patients with chronic hepatitis C.These results indicate that the HCV core protein has a major role in the development of HCC and that HCV itself is directly involved in hepatocarcinogenesis.

  • Research Products

    (13 results)

All Other

All Publications (13 results)

  • [Publications] K.Moriya et al.: "Hepatitis C virus Core protein induces hopatocellular carcinoma in trangenic mice"Nat Med. 4. 1065-1068 (1988)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Fujie et al.: "Steatosis and intratepatic hepatitis C virus in chronic hepatitis"J Med Virol. 59. 141-145 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Shintani et al.: "Induction of apoptosis after the switch-on of the hepatitis B virus X gene medioctal by Crell ox P recombinase system"J Gem Virol. 80. 3257-3266 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Koike et al.: "Survey of hepatitis B virus co-infection in Lepatitis C virus-infected patients suffering from chronic hepatitis and hypotocellula caratmo in Japan"Jpn J Cancer Res. 90. 1270-1272 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Koike: "Travsgenic mouse model of viral hapatitis : Insight into viral hepato carciaogenesis"Viral Hepatitis Rev. 5(in press). (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Yotsuyanagi et al.: "Virological analysis of "non-B, non-C" hepatocellular carcioma in Japan"J Infect Dis. 181(in press). (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Moriya, H.Fujie, Y.Shintani, H.Yotsuyanagi, T.Tsutsumi, Y.Matsuura, S.Kimura, T.Miyamura, K.Koike.: "Hepatitis C virus core protein induces hepatocellular carcinoma in transgenic mice."Nature Med.. 4. 1065-1068 (1998)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Fujie, H.Yotsuyanagi, K.Moriya, Y.Shintani, T.Tsutsumi, T.Takayama, M.Makuuchi, Y.Matsuura, T.Miyamura, S.Kimura, K.Koike.: "Steatosis and Intrahepatic hepatitis C virus in chronic hepatitis."J Med Virol. 59. 141-145 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Shintani, H.Yotsuyanagi, K.Moriya, H.Fujie, T.Tsusumi, Y.Kanegae, S.Kimura, I.Saito, K.Koike.: "Induction of apoptosis after the switch-on of the hepatitis B virus X gene mediated by Cre/loxP recombinase system."J Gen Virol. 80. 3257-3266 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Koike, K.Shimotohno, S.Okada, H.Okamoto, N.Hayashi, K.Ueda, S.Kaneko, K.Koike, O.Yokosuka, et al.: "Survey of hepatitis B virus co-infection in hepatitis C virus-infected patients suffering from chronic hepatitis and hepatocellular carcinoma in Japan."Jpn J Cancer Res. 90. 1270-1272 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K.Koike: "Transgenic mouse models of viral hepatitis : Insight into viral hepatocarcinogenesis."Viral Hepatitis Rev.. (in press). (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H.Yotsuyanagi, Y.Shintani, K.Moriya, H.Fujie, T.Tsutsumi, T.Kato, K.Nishioka, T.Takayama, M.Makuuchi, S.Iino, S.Kimura, K.Koike.: "Virological analysis of "non-B, non-C" hepatocellular carcinoma in Japan : frequent involvement of hepatitis B virus.."J Infect Dis. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y.Shintani, H.Yotsuyanagi, K.Moriya, H.Fujie, T.Tsutsumi, T.Takayama, M.Makuuchi, S.Kimura, K.Koike.: "Significance of hepatitis B virus DNA detected in hepatocellular carcinoma in patients with hepatitis C."Cancer. (in press). (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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