2002 Fiscal Year Annual Research Report

がんの生物学的特性に関する研究の総括

Research Project

Project/Area Number	11179101
Research Institution	Osaka University
Principal Investigator	高井義美大阪大学, 医学系研究科, 教授 (60093514)
Co-Investigator(Kenkyū-buntansha)	清木元治東京大学, 医科学研究所, 教授 (10154634) 秋山徹東京大学, 分子細胞生物学研究所, 教授 (70150745) 平井久丸東京大学, 医学部附属病院, 助教授 (90181130) 谷口維紹東京大学, 医科学研究科, 教授 (50133616) 渋谷正史東京大学, 医科学研究所, 教授 (10107427)
Keywords	がん / 増殖因子 / シグナル伝達 / 分化 / 細胞死 / 細胞周期 / 浸潤・転移 / 細胞外マトリックス
Research Abstract	本領域は「がん研究の総合的推進に関する研究」の一環として、がんの生物学的研究を担うものである。すなわち、がんの生物学的特性を明らかにすることによって、がんの予防、診断、治療に貢献することを目的とする。本年度の総括班における成果を以下に列記する。 1.がんの生物学的研究の分野において未解決の重要な問題を解明するために、総括班は以下の5項目について研究を計画した。A01:がん細胞の増殖応答の異常の研究、A02:がんの形成過程における細胞の分化と死の研究、A03:がん細胞の制御異常とがん形質の研究、A04:がん細胞の浸潤と転移の研究、A05:組織形成異常とがんとの関連の研究。 2.領域代表者である高井義美をA01の班長とし、以下、A02平井久丸、A03秋山徹、A04清木元治、A05渋谷正史とした。また、本研究分野で顕著な業績を持つ研究者5名(谷口維紹、宮島篤、月田承一郎、西田栄介、広橋説雄)を総括班に加え、主として研究計画実施の方針に対する助言および各研究項目長とともに研究成果の評価にあたることとした。 3.研究を推進するために、重要かつ緊急性のあるテーマと優れた研究者を計画的に支援する目的で、各項目ごとで、総計40の研究計画を設定し、これに担当する研究代表者と分担者の選定と研究内容の評価を行った。また、公募により自由な発想に基づく研究を募集し、この研究内容を評価した。 4.総括班会議および分野長会議を開催しており、上記重要課題につき検討上、方針を決定し領域の円滑な運営を進めた。このように、私共は、本年度の予定をほぼ達成することができた。

Research Products

(20 results)

All Other

All Publications (20 results)

[Publications] Kawakatsu, T.: "Trans-interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins"J. Biol. Chem.. 277・52. 50749-50755 (2002)
[Publications] Takekuni, K.: "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse"J. Biol. Chem.. 278・8. 5497-5500 (2003)
[Publications] Izutsu, K.: "The t(3;21) fusion product, AML1/Evi-1, blocks AML1-induced transactivation by recruiting CtBP"Oncogene. 21・17. 2695-2703 (2002)
[Publications] Suzuki, T.: "MICAL, a novel CasL interacting molecule, associates with vimentin"J. Biol. Chem.. 277・17. 14933-14941 (2002)
[Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells"Nature Cell Biology. 5・3. 211-215 (2003)
[Publications] Jimbo, T.: "Identification of link between the tumor suppressor APC and the kinesin superfamily of protein"Nature Cell Biology. 4・4. 323-327 (2002)
[Publications] Mori, H.: "CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain"EMBO J.. 21・15. 3949-3959 (2002)
[Publications] Seiki, M.: "The cell surface : the stage for matrix metalloproteinase regulation of migration"Curr. Opin. Cell Biol.. 14・5. 624-632 (2002)
[Publications] Hiratsuka, S.: "MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 is involved in lung secific metastasis"Cancer Cell. 2・4. 289-300 (2002)
[Publications] Kiba, A.: "A set of loop-1 and -3 structures in the novel VEGF family member, VEGF-E_<NZ-7>, is essential for the activation of VEGFR-2 signaling"J. Biol. Chem.. (in press). (2003)
[Publications] Takayanagi, H.: "RANKL maintains bone homeostasis through c-Fos-dependent induction of IFN-β"Nature. 416・6882. 744-749 (2002)
[Publications] Takayanagi, H.: "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts"Dev Cell. 3・6. 889-901 (2002)
[Publications] Nakayama, K.: "A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3"EMBO J.. 21・22. 6174-6184 (2002)
[Publications] Matsui, T.: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J.. 21・5. 1021-1030 (2002)
[Publications] Furuse, M.: "Claudin-based tight junctions are crucial for the mammalian epidermal barrier : A lesson from claudin-1-deficient mice"J. Cell Biol.. 156・6. 1099-1111 (2002)
[Publications] Kikuchi, S.: "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes"Nat. Genet.. 31・3. 320-325 (2002)
[Publications] Hanafusa, H.: "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway"Nature Cell Biol.. 4・11. 850-858 (2002)
[Publications] Yamanaka, H.: "JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates"EMBO Rep.. 3・1. 69-75 (2002)
[Publications] Nakanishi, K.: "Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer"Cancer Res.. 62・10. 2971-2975 (2002)
[Publications] Sekine, S.: "Target disruption of the mutant β-catenin gene in colon cancer cell line HCT116 : preservation of its malignant phenotype"Oncogene. 21・38. 5906-5911 (2002)

2002 Fiscal Year Annual Research Report

がんの生物学的特性に関する研究の総括

Principal Investigator

高井 義美 大阪大学, 医学系研究科, 教授 (60093514)

Research Products

[Publications] Kawakatsu, T.: "Trans-interactions of nectins induce formation of filopodia and lamellipodia through the respective activation of Cdc42 and Rac small G proteins"J. Biol. Chem.. 277・52. 50749-50755 (2002)

[Publications] Takekuni, K.: "Direct binding of cell polarity protein PAR-3 to cell-cell adhesion molecule nectin at neuroepithelial cells of developing mouse"J. Biol. Chem.. 278・8. 5497-5500 (2003)

[Publications] Izutsu, K.: "The t(3;21) fusion product, AML1/Evi-1, blocks AML1-induced transactivation by recruiting CtBP"Oncogene. 21・17. 2695-2703 (2002)

[Publications] Suzuki, T.: "MICAL, a novel CasL interacting molecule, associates with vimentin"J. Biol. Chem.. 277・17. 14933-14941 (2002)

[Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells"Nature Cell Biology. 5・3. 211-215 (2003)

[Publications] Jimbo, T.: "Identification of link between the tumor suppressor APC and the kinesin superfamily of protein"Nature Cell Biology. 4・4. 323-327 (2002)

[Publications] Mori, H.: "CD44 directs membrane-type 1 matrix metalloproteinase to lamellipodia by associating with its hemopexin-like domain"EMBO J.. 21・15. 3949-3959 (2002)

[Publications] Seiki, M.: "The cell surface : the stage for matrix metalloproteinase regulation of migration"Curr. Opin. Cell Biol.. 14・5. 624-632 (2002)

[Publications] Hiratsuka, S.: "MMP9 induction by Vascular Endothelial Growth Factor Receptor-1 is involved in lung secific metastasis"Cancer Cell. 2・4. 289-300 (2002)

[Publications] Kiba, A.: "A set of loop-1 and -3 structures in the novel VEGF family member, VEGF-E_<NZ-7>, is essential for the activation of VEGFR-2 signaling"J. Biol. Chem.. (in press). (2003)

[Publications] Takayanagi, H.: "RANKL maintains bone homeostasis through c-Fos-dependent induction of IFN-β"Nature. 416・6882. 744-749 (2002)

[Publications] Takayanagi, H.: "Induction and activation of the transcription factor NFATc1 (NFAT2) integrate RANKL signaling for terminal differentiation of osteoclasts"Dev Cell. 3・6. 889-901 (2002)

[Publications] Nakayama, K.: "A novel nuclear zinc finger protein EZI enhances nuclear retention and transactivation of STAT3"EMBO J.. 21・22. 6174-6184 (2002)

[Publications] Matsui, T.: "K-Ras mediates cytokine-induced formation of E-cadherin-based adherens junctions during liver development"EMBO J.. 21・5. 1021-1030 (2002)

[Publications] Furuse, M.: "Claudin-based tight junctions are crucial for the mammalian epidermal barrier : A lesson from claudin-1-deficient mice"J. Cell Biol.. 156・6. 1099-1111 (2002)

[Publications] Kikuchi, S.: "Radixin deficiency causes conjugated hyperbilirubinemia with loss of Mrp2 from bile canalicular membranes"Nat. Genet.. 31・3. 320-325 (2002)

[Publications] Hanafusa, H.: "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway"Nature Cell Biol.. 4・11. 850-858 (2002)

[Publications] Yamanaka, H.: "JNK functions in the non-canonical Wnt pathway to regulate convergent extension movements in vertebrates"EMBO Rep.. 3・1. 69-75 (2002)

[Publications] Nakanishi, K.: "Critical involvement of the phosphatidylinositol 3-kinase/Akt pathway in anchorage-independent growth and hematogeneous intrahepatic metastasis of liver cancer"Cancer Res.. 62・10. 2971-2975 (2002)

[Publications] Sekine, S.: "Target disruption of the mutant β-catenin gene in colon cancer cell line HCT116 : preservation of its malignant phenotype"Oncogene. 21・38. 5906-5911 (2002)

高井義美大阪大学, 医学系研究科, 教授 (60093514)