2003 Fiscal Year Annual Research Report

がんの生物学的特性に関する研究の総括

Research Project

Project/Area Number	11179101
Research Institution	Osaka University
Principal Investigator	高井義美大阪大学, 医学系研究科, 教授 (60093514)
Co-Investigator(Kenkyū-buntansha)	清木元治東京大学, 医科学研究所, 教授 (10154634) 秋山徹東京大学, 分子細胞生物学研究所, 教授 (70150745) 金倉譲大阪大学, 医学系研究科, 教授 (20177489) 渋谷正史東京大学, 医科学研究所, 教授 (10107427)
Keywords	がん / 増殖因子 / シグナル伝達 / 分化 / 細胞死 / 細胞周期 / 浸潤・転移 / 細胞外マトリックス
Research Abstract	本領域は「がん研究の総合的推進に関する研究」の一環として、がんの生物学的研究を担うものである。すなわち、がんの生物学的特性を明らかにすることによって、がんの予防、診断、治療に貢献することを目的とする。本年度の総括班における成果を以下に列記する。 1.がんの生物学的研究の分野において未解決の重要な問題を解明するために、総括班は以下の5項目について研究を計画した。A01:がん細胞の増殖応答の異常の研究、A02:がんの形成過程における細胞の分化と死の研究、A03:がん細胞の制御異常とがん形質の研究、A04:がん細胞の浸潤と転移の研究、A05:組織形成異常とがんとの関連の研究。 2.領域代表者である高井義美をA01の分野長とし、以下、A02平井久丸、A03秋山徹、A04清木元治、A05渋谷正史とした。平成15年8月、平井久丸先生の死去に伴って、A02の分野長を金倉譲が担当することとした。 3.研究を推進するために、重要かつ緊急性のあるテーマと優れた研究者を計画的に支援する目的で、総計40の研究計画を設定し、これに担当する研究代表者と分担者の選定、および研究内容の評価を行った。また、公募により自由な発想に基づく研究を募集し、この研究内容を評価した。評価はおおむね良く、着実に成果が出ているとのことであった。 4.総括班会議および分野長会議を開催し、上記重要課題につき検討した上で方針を決定し、領域の円滑な運営を進めた。このように今年度は、当初に計画した研究目的、研究計画・方法に対し、予定をほぼ達成することができたと考えている。今後、本研究計画を継続することにより、本研究の最終目的を達成する見通しは明るいと判断している。

Research Products

(15 results)

All Other

All Publications (15 results)

[Publications] Ikeda, W.: "Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration."J.Biol.Chem.. 278・30. 28167-28172 (2003)
[Publications] Fukuhara. A.: "Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells."J.Biol.Chem.. 278・51. 51885-51893 (2003)
[Publications] Ikeda, W.: "Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, nectin-3-independent manner."J.Biol.Chem.. in press. (2004)
[Publications] Shibayama, H.: "Identification of a cytokine-induced anti-apoptotic molecule Anamorsin essential for definitive hematopoiesis."J.Exp.Med.. in press. (2004)
[Publications] Kawasaki, A.: "Opposing effects of PML and PML/RARα on STAT3 activities."Blood. 101・9. 3668-3673 (2002)
[Publications] Kataoka, Y.: "Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts."J.Biol.Chem.. 278・45. 44178-44187 (2003)
[Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells."Nature Cell Biology. 5・3. 211-215 (2003)
[Publications] Okabe, T.: "RICS, a novel GTPase-Activating Protein for Cdc42 and Rac1,is involved in the b-catenin-N-cadherin and NMDA receptor signaling."J.Biol.Chem.. 278・11. 9920-9927 (2003)
[Publications] Sekiya, T.: "Identification of BAMBI, an inhibitor of TGF-b signaling, as a target of the b-catenin pathway in colorectal tumor cells."J Biol Chem.. 279・8. 6840-6846 (2004)
[Publications] Uekita, T.: "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) is a new member of the Cupin superfamily : A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors."J Biol Chem.. in press. (2004)
[Publications] Matsuki, H.: "Monoclonal antibodies with defined recognition sequences in the stem region of CD44 : detection of differential glycosylation of CD44 between tumor and stromal cells in tissue."Cancer Res.. 63. 8278-8283 (2003)
[Publications] Matsuda, A.: "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils."J Biol Chem.. 278・38. 36350-36357 (2003)
[Publications] Kiyono, M.: "Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression."Mol.Cell.Biol.. 23・13. 4627-4636 (2003)
[Publications] Autiero, M.: "Role of PIGF in the intra- and inter-molecular crolltalk between VEGF receptors Flt1 and Flk1."Nature Med.. 9・7. 936-943 (2003)
[Publications] Saito, M.: "Tubular Formation by Angiopoietin-1 in Endothelial Cell/Fibroblast Co-culture is Dependent on Endogenous VEGF."Cancer Science. 94・9. 782-790 (2003)

2003 Fiscal Year Annual Research Report

がんの生物学的特性に関する研究の総括

Principal Investigator

高井 義美 大阪大学, 医学系研究科, 教授 (60093514)

Research Products

[Publications] Ikeda, W.: "Tage4/nectin-like molecule-5 heterophilically trans-interacts with cell adhesion molecule nectin-3 and enhances cell migration."J.Biol.Chem.. 278・30. 28167-28172 (2003)

[Publications] Fukuhara. A.: "Involvement of nectin-activated Cdc42 small G protein in organization of adherens and tight junctions in Madin-Darby canine kidney cells."J.Biol.Chem.. 278・51. 51885-51893 (2003)

[Publications] Ikeda, W.: "Nectin-like molecule-5/Tage4 enhances cell migration in an integrin-dependent, nectin-3-independent manner."J.Biol.Chem.. in press. (2004)

[Publications] Shibayama, H.: "Identification of a cytokine-induced anti-apoptotic molecule Anamorsin essential for definitive hematopoiesis."J.Exp.Med.. in press. (2004)

[Publications] Kawasaki, A.: "Opposing effects of PML and PML/RARα on STAT3 activities."Blood. 101・9. 3668-3673 (2002)

[Publications] Kataoka, Y.: "Reciprocal inhibition between MyoD and STAT3 in the regulation of growth and differentiation of myoblasts."J.Biol.Chem.. 278・45. 44178-44187 (2003)

[Publications] Kawasaki, Y.: "Mutated APC and Asef are involved in migration of colorectal tumor cells."Nature Cell Biology. 5・3. 211-215 (2003)

[Publications] Okabe, T.: "RICS, a novel GTPase-Activating Protein for Cdc42 and Rac1,is involved in the b-catenin-N-cadherin and NMDA receptor signaling."J.Biol.Chem.. 278・11. 9920-9927 (2003)

[Publications] Sekiya, T.: "Identification of BAMBI, an inhibitor of TGF-b signaling, as a target of the b-catenin pathway in colorectal tumor cells."J Biol Chem.. 279・8. 6840-6846 (2004)

[Publications] Uekita, T.: "Membrane-type 1 matrix metalloproteinase cytoplasmic tail binding protein-1 (MTCBP-1) is a new member of the Cupin superfamily : A possible multifunctional protein acting as an invasion suppressor down-regulated in tumors."J Biol Chem.. in press. (2004)

[Publications] Matsuki, H.: "Monoclonal antibodies with defined recognition sequences in the stem region of CD44 : detection of differential glycosylation of CD44 between tumor and stromal cells in tissue."Cancer Res.. 63. 8278-8283 (2003)

[Publications] Matsuda, A.: "Clusterin, an abundant serum factor, is a possible negative regulator of MT6-MMP/MMP-25 produced by neutrophils."J Biol Chem.. 278・38. 36350-36357 (2003)

[Publications] Kiyono, M.: "Bone morphogenetic protein 4 mediates apoptosis of capillary endothelial cells during rat pupillary membrane regression."Mol.Cell.Biol.. 23・13. 4627-4636 (2003)

[Publications] Autiero, M.: "Role of PIGF in the intra- and inter-molecular crolltalk between VEGF receptors Flt1 and Flk1."Nature Med.. 9・7. 936-943 (2003)

[Publications] Saito, M.: "Tubular Formation by Angiopoietin-1 in Endothelial Cell/Fibroblast Co-culture is Dependent on Endogenous VEGF."Cancer Science. 94・9. 782-790 (2003)

高井義美大阪大学, 医学系研究科, 教授 (60093514)