2002 Fiscal Year Annual Research Report

ポリ乳酸をベースとする生分解性ポリエステルの構造と物理的特性に関する研究

Research Project

Project/Area Number	11217209
Research Institution	Toyohashi University of Technology
Principal Investigator	辻秀人豊橋技術科学大学, 工学部, 助教授 (60227395)
Keywords	生分解性高分子材料 / 生分解性ポリエステル / ポリ乳酸 / ポリ(ε-カプロラクトン) / 表面親水化 / 微粒子充填材料 / 酵素的加水分解 / ポリマーブレンド
Research Abstract	14年度は、主に以下の4つの項目に関する研究を行った。 1.ポリ(L-乳酸)(PLLA)の微粒子充填複合材料の物理特性および生分解性 CaCO_3添加量の増加とともにPLLAの弾性率は上昇し、強度は一定の添加量を越えると減少する傾向を示した。PLLAの酵素的加水分解速度は、添加量5-20wt%の範囲までは著しく上昇するが、それを越えると低下した。 2.生分解性ポリエステルブレンドの物理特性および生分解性に与える相溶化剤の影響フィルムの弾性率はブレンド比[X=PLLAの重量/{ポリ(ε-カプロラクトン)(PCL)の重量+PLLAの重量}]が0.6-0.8範囲において、強度はX=0-0.1および0.5-0.8の範囲において、破断伸度は全てのXにおいて、両者の共重合体を添加した方が高くなった。また、共重合体の添加は、ブレンドおよび非ブレンドフィルム両者の酵素的加水分解速度を低下させた。 3.PLLAの種々の媒体中における表面親水化と加水分解機構 PLLAのproteinase Kによる加水分解は、endo的およびexo的に表面から進行するため、厚い材料の表面親水化には適する。NaOH水溶液による加水分解は、endo的に表面から進行するため、PLLA材料の厚みを問わず、親水化の有効な方法であることがわかった。これに対して、リン緩衝液による加水分解では、endo的に材料全体的に進行するため、親水性が上昇する以前に材料は崩壊した。 4.ポリ乳酸(PLA)の立体規則性および鏡像異性体ブレンドが白己触媒的加水分解に与える影響立体規則性の高いPLLAおよびポリ(D-乳酸)(PDLA)の自己触媒的加水分解速度は、立体規則性の低いポリ(DL-乳酸)(PDLLA)の加水分解速度よりも低いが、PLLA鎖とPDLA鎖の相互作用の強いPLLA/PDLAブレンドの加水分解速度よりも高いことが明らかとなった。

Research Products

(18 results)

All Other

All Publications (18 results)

[Publications] Hideto Tsuji, Tamami Yamada: "Blends of Aliphatic Polyesters, VIII. Effects of Poly(L-lactide-CO-ε-caprolactone) on Enzymatic Hydrolysis of Poly(L-lactide), Poly(ε-caprolactone), and Their Blend Films"Journal of Applied Polymer Science. 87・3. 412-419 (2003)
[Publications] Hideto Tsuji, Takuya Ishida: "Poly(L-lactide) : X Enhanced Surface Hydrophilicity and Chain-Scission Mechanisms of Poly(L-lactide) Film in Enzymatic, Alkaline, and Phosphate-Buffered Solutions"Journal of Applied Polymer Science. 87・10. 1628-1633 (2003)
[Publications] Hideto Tsuji: "In Vitro Hydrolysis of Blends from Enantiomeric Poly(lactide)s 4 Well-Homo-Crystallized Blends and Nonblended Films"Biomaterials. 24・4. 537-547 (2003)
[Publications] Hideto Tsuji, Carlos Adriel Del Carpio: "In Vitro Hydrolysis of Blends from Enantiomeric Poly(lactide)s 3 Homo-Crystallized and Amorphous Blend Films"Biomacromolecules. 4・1. 7-11 (2003)
[Publications] Hideto Tsuji, Tamami Yamada, Masakazu Suzuki, Shinichi Itsuno: "Blends of Aliphatic Polyesters : VII Effects of Poly(L-lactide-CO-ε-caprolactone) on Marphology, Structure, Crystallization, and Physical Properties of Blends of Poly(L-lactide) and Poly(ε-lactone)"Polymer International. 52・2. 269-275 (2003)
[Publications] Hideto Tsuji, Takuya Ishida: "Surface Hydrophilicity and Enzymatic Hydrolyzability of Biodegradable Polyesters. 2. Effects of Hydrophilic Polymer Coating"Macromolecular Bioscience. 3・1. 51-59 (2003)
[Publications] Norio Fukuda, Hideto Tsuji, Yasushi Ohnishi: "Physical Properties and Enzymatic Hydrolysis of Poly(L-lactide)-CaCO_3 Composites"Polymer Degradation and Stability. 78・1. 119-127 (2002)
[Publications] Hideto Tsuji, Kazumasa Nakahara: "Poly(L-lactide) : IX. Hydrolysis in Acid Media"Journal of Applied Polymer Science. 86・1. 186-194 (2002)
[Publications] Hideto Tsuji: "Autocatalytic Hydrolysis of Amorphous-Made Polylactides : Effects of L-lactide Content, Tacticity, and Enantiomeric Polymer Blending"Polymer. 43・6. 1789-1796 (2002)
[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 2. Poly(ε-caprolactone), Poly[(R)-3-hydroxybutyrate], and poly(L-lactide) Films in Natural Dynamic Seawater"Polymer Degradation and Stability. 75・2. 357-363 (2002)
[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 1. Poly(ε-caprolactone), Poly[(R)-3-hydroxybutyrate], and poly(L-lactide) Films in Controlled Static Seawater"Polymer Degradation and Stability. 75・2. 347-355 (2002)
[Publications] Hideto Tsuji, Takuya Ishida, Norio Fukuda: "Surface Hydrophilicity and Enzymatic Hydrolyzability of Biodegradable Polyesters. 1. Effects of Alkaline Treatment"Polymer International. (印刷中).
[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 4. Effects of Pores and Surface Hydrophilicity on Biodegradation of Poly(ε-caprolactone), Poly[(R)-3-hydoxybutyrate] Films in Controlled Seawater"Journal of Applied Polymer Science. (印刷中).
[Publications] Kosuke Tomita, Hideto Tsuji他4名: "Degradation of Poly(D-lactide) by a Thermophile"Polymer Degradation and Stability. (印刷中).
[Publications] Hideto Tsuji, Ippei Fukui: "Enhanced Thermal Stability of Poly(lactide)s in the Melt by Enantiomeric Polymer Blending"Polymer. (印刷中).
[Publications] Hideto Tsuji, Hiroyuki Daimon, Koichi Fujie: "A New Strategy For Recyding and Preparation of Poly(L-lactide)"Biomacromolecules. (印刷中).
[Publications] 辻秀人: "生分解性高分子材料の科学"コロナ社. 228 (2002)
[Publications] 辻秀人: "グリーンプラスチック最新技術(井上義夫監修)"シーエムシー. 17 (2002)

2002 Fiscal Year Annual Research Report

ポリ乳酸をベースとする生分解性ポリエステルの構造と物理的特性に関する研究

Principal Investigator

辻 秀人 豊橋技術科学大学, 工学部, 助教授 (60227395)

Research Products

[Publications] Hideto Tsuji, Tamami Yamada: "Blends of Aliphatic Polyesters, VIII. Effects of Poly(L-lactide-CO-ε-caprolactone) on Enzymatic Hydrolysis of Poly(L-lactide), Poly(ε-caprolactone), and Their Blend Films"Journal of Applied Polymer Science. 87・3. 412-419 (2003)

[Publications] Hideto Tsuji, Takuya Ishida: "Poly(L-lactide) : X Enhanced Surface Hydrophilicity and Chain-Scission Mechanisms of Poly(L-lactide) Film in Enzymatic, Alkaline, and Phosphate-Buffered Solutions"Journal of Applied Polymer Science. 87・10. 1628-1633 (2003)

[Publications] Hideto Tsuji: "In Vitro Hydrolysis of Blends from Enantiomeric Poly(lactide)s 4 Well-Homo-Crystallized Blends and Nonblended Films"Biomaterials. 24・4. 537-547 (2003)

[Publications] Hideto Tsuji, Carlos Adriel Del Carpio: "In Vitro Hydrolysis of Blends from Enantiomeric Poly(lactide)s 3 Homo-Crystallized and Amorphous Blend Films"Biomacromolecules. 4・1. 7-11 (2003)

[Publications] Hideto Tsuji, Takuya Ishida: "Surface Hydrophilicity and Enzymatic Hydrolyzability of Biodegradable Polyesters. 2. Effects of Hydrophilic Polymer Coating"Macromolecular Bioscience. 3・1. 51-59 (2003)

[Publications] Norio Fukuda, Hideto Tsuji, Yasushi Ohnishi: "Physical Properties and Enzymatic Hydrolysis of Poly(L-lactide)-CaCO_3 Composites"Polymer Degradation and Stability. 78・1. 119-127 (2002)

[Publications] Hideto Tsuji, Kazumasa Nakahara: "Poly(L-lactide) : IX. Hydrolysis in Acid Media"Journal of Applied Polymer Science. 86・1. 186-194 (2002)

[Publications] Hideto Tsuji: "Autocatalytic Hydrolysis of Amorphous-Made Polylactides : Effects of L-lactide Content, Tacticity, and Enantiomeric Polymer Blending"Polymer. 43・6. 1789-1796 (2002)

[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 2. Poly(ε-caprolactone), Poly[(R)-3-hydroxybutyrate], and poly(L-lactide) Films in Natural Dynamic Seawater"Polymer Degradation and Stability. 75・2. 357-363 (2002)

[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 1. Poly(ε-caprolactone), Poly[(R)-3-hydroxybutyrate], and poly(L-lactide) Films in Controlled Static Seawater"Polymer Degradation and Stability. 75・2. 347-355 (2002)

[Publications] Hideto Tsuji, Takuya Ishida, Norio Fukuda: "Surface Hydrophilicity and Enzymatic Hydrolyzability of Biodegradable Polyesters. 1. Effects of Alkaline Treatment"Polymer International. (印刷中).

[Publications] Hideto Tsuji, Kaori Suzuyoshi: "Environmental Degradation of Biodegradable Polyesters : 4. Effects of Pores and Surface Hydrophilicity on Biodegradation of Poly(ε-caprolactone), Poly[(R)-3-hydoxybutyrate] Films in Controlled Seawater"Journal of Applied Polymer Science. (印刷中).

[Publications] Kosuke Tomita, Hideto Tsuji他4名: "Degradation of Poly(D-lactide) by a Thermophile"Polymer Degradation and Stability. (印刷中).

[Publications] Hideto Tsuji, Ippei Fukui: "Enhanced Thermal Stability of Poly(lactide)s in the Melt by Enantiomeric Polymer Blending"Polymer. (印刷中).

[Publications] Hideto Tsuji, Hiroyuki Daimon, Koichi Fujie: "A New Strategy For Recyding and Preparation of Poly(L-lactide)"Biomacromolecules. (印刷中).

[Publications] 辻 秀人: "生分解性高分子材料の科学"コロナ社. 228 (2002)

[Publications] 辻 秀人: "グリーンプラスチック最新技術(井上義夫監修)"シーエムシー. 17 (2002)

辻秀人豊橋技術科学大学, 工学部, 助教授 (60227395)

[Publications] 辻秀人: "生分解性高分子材料の科学"コロナ社. 228 (2002)

[Publications] 辻秀人: "グリーンプラスチック最新技術(井上義夫監修)"シーエムシー. 17 (2002)