Co-Investigator(Kenkyū-buntansha) |
HIROFUMI Yamada Kyoto University.Graduate School of Engineering, Associate Professor, 大学院・工学研究科, 助教授 (40283626)
ATSUSHI Ikai Tokyo Institute of Technology.Graduate School of Bioscience and Biotechnology, Professor, 大学院・生命理工学研究科, 教授 (50011713)
MASARU Tsukada University of Tokoy.Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (90011650)
YASUHIRO Iwasawa University of Tokyo.Graduate School of Science, Professor, 大学院・理学系研究科, 教授 (40018015)
AKIO Yoshimori Okayama University of Science, Faculty of Informatics, Professor, 総合情報学部, 教授 (50013470)
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Research Abstract |
Tsukada Group developed a method of theoretical simulation of nc-AFM images which was applied to the analyses of Si (111) 7x7, Si (100) and Si (111) √3x√3-Ag surface. Then, his group clarified the relationship between the dissipation term and non-conservative surface atomic processes, and its effect on the frequency shift. Besides, his group studied dissipation in detail. Further, his group investigated the influence of thermal fluctuation of surface structure on the nc-AFM image. Morita Group found atomic site-dependences of the tip-sample interaction and contact points on Si (111) 7x7 sample surfaces by investigating the spectroscopic effects using nc-AFM.Besides, his group found tip-sample distance dependence of the nc-AFM image on Si (111) √3x√3-Ag sample surfaces. Further, by replacing the tip apex atom with a suitable atom, his group selectively controlled the atomic force between the tip apex and sample surface atoms. Yamada group developed a novel control electronics of a dynamic
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force microscopy for organic molecules with anisotropic, large structures and greatly improved the sensitivity in the frequency modulation detection. Thereby molecularly resolved images of C60 molecules on Si (111) and alkanethiol molecules on Au (111) were successfully obtained. In addition, the inital stages of the crystalline growth of ferroelectric molecules were clearly revealed. Ikai Group determined the intramolecular cohesive energy of a protein molecule by integrating a force-extension curve of the globular protein, carbonic dehydratase. His group also demonstrated that mechanical properties of the protein change drastically upon binding of a low molecular weight ligand, which provided us a basis to develop a nano-mechanical methodology as a research tool for the study of intermolecular interactions. Their nano-mechanical study of protein molecules revealed the presence of hitherto unnoticed mechanical conformers for a carbonic anhydrase mutant protein showing the precision of nano-mechanical methodology. Less
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