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2002 Fiscal Year Final Research Report Summary

Regulative Mechanisms and Manipulation of the Germ Cell Lineage

Research Project

Project/Area Number 11234101
Research Category

Grant-in-Aid for Scientific Research on Priority Areas

Allocation TypeSingle-year Grants
Review Section Biological Sciences
Research InstitutionKYOTO UNIVERSITY

Principal Investigator

NAKATSUJI Norio  Kyoto University, Institute for Frontier Medical Sciences, Professor, 再生医科学研究所, 教授 (80237312)

Co-Investigator(Kenkyū-buntansha) NAGAHAMA Yoshitaka  Institute for Basic Biology, Professor, 基礎生物学研究所, 教授 (50113428)
KATSUKI Motoya  Institute for Basic Biology, Director, 基礎生物学研究所, 所長 (20051732)
NISHIMUNE Yoshitake  Osaka University, Institute for Medical Microbiology, Professor, 微生物病研究所, 教授 (80029793)
YAMAMURA Kenichi  Kumamoto University Medical School, Professor, 医学部, 教授 (90115197)
TSUNODA Yukio  Kinki University, Faculty of Agriculture, Professor, 農学部, 教授 (80217364)
Project Period (FY) 1999 – 2002
KeywordsGerm cells / mammalian / embryo manipulation / germ lineage
Research Abstract

This research group was aimed at facilitating and encouraging scientific interactions and collaboration among the scientists involved in this priority area. For such purpose, this group organized annual meeting of the priority area, and also symposia open to general scientists. The most significant was the international symposium on "Development and Epigenetics of Mammalian Germ Cells and Pluripotent Stem Cells, "held on 19-21 November, 2001 in Kyoto, with more than 300 participants and 25 speakers.
Speakers includes : Anne McLaren (Cambridge, UK) "Germ cells and stem cells : the key to developmental potency"/Patrick Tam (Sydney, Australia) "Allocation and differentiation of the progenitors for germ cells and urogenital tissues"/Austin Smith (Edinburgh, UK) "Signalling self-renewal in pluripotent stem cells"/Guang-Quan Zhao (Dallas, USA) "BMP signaling in the generation of primordial germ cells in the mouse"/Chris Wylie (Cincinnati, USA)"Migration of mouse primordial germ cells"/Robin L … More ovell-Badge (London, UK)"The Molecular Genetics of Sex Determination in Mammals : Building Pathways"/Azim Surani (Cambridge, UK)"The origin and properties of the mouse germ line."/N. B. Hecht (Philadelphia, USA)"Selective intracellular and intercellular mRNA transport in mammalian germ cells"/Hitoshi Niwa (Center for Developmental Biology, RIKEN, Japan) /Yukio Tsunoda (Kinki Univ., Japan)/Nobuo Takagi (Hokkaido Univ., Japan)/Hiroyuki Sasaki (Nat. Inst. of Genetics, Japan)/Fumitoshi Ishino (Tokyo Inst. for Technology, Japan)"Genomic imprinting in the germ cell lineage"/Takashi Tada (Kyoto Univ., Japan)/Junji Takeda (Osaka Univ., Japan)/Kuniya Abe (Kumamoto Univ., Japan), Yasuhisa Matsui (Osaka Medical Center for Maternal and Child Health, Japan), Toshiaki Noce (Mitsubishi-Kagaku Inst. of Life Sciences, Japan), Norio Nakatsuji (Kyoto Univ., Japan), Tomohiro Kono (Tokyo Univ. of Agriculture, Japan), Atsuo Ogura (Nat. Inst. of Infectious Diseases, Japan), Hiroshi Nojima (Osaka Univ., Japan), Masami Nozaki (Osaka Univ., Japan), Masaru Okabe (Osaka Univ., Japan), Gen Kondoh (Osaka Univ., Japan) Less

  • Research Products

    (38 results)

All Other

All Publications (38 results)

  • [Publications] Kanno, Y., Tamura, M., Chuma, S., Sakurai, T., Machida, T.and Nakatsuji, N.: "A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation"Int. J. Dey. Biol.. 43. 777-784 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tada, T., Obata, Y.Tada, M., Goto, Y., Nakatsuji, N., Tan, S-S., Kono, T., Takagi, N.: "Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth"Development. 127. 3101-3105 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Huang, Z., Tamura, M., Sakurai, T., Chuma, S., Saito, T., Nakatsuji, N.: "In vivo transfection of testicular germ cells and transgenenis by using the mitochondrially localized jellyfish fluorescent protein gene"FEBS Lett.. 487. 248-251 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.S.Tanaka, Y.Toyooka, R.Akasu, Y Katoh-Fukui, Y.Nakahara, R.Suzuki, M.Yokoyama, T.Noce.: "Mouse homolog gene to Drosophila Vasa is required for the development of male germ cells"Genes & Dev.. 14. 841-853 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Toyooka, N.Tsunekawa, Y.Takahashi, Y.Matsui, M.Satoh, T.Noce.: "Expression and intracellular localizationof mouse Vasa-homolog protein during germ cell development"Mech. Dev.. 93. 139-149 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chuma, S., Nakatsuji, N.: "Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp 130-mediated signaling"Devel. Biol.. 229. 468-479 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakatsuji, N.and Chuma, S.: "Differentiation of mouse primordial germ cells into female or male germ cells"Int. J. Dev. Biol.. 45. 541-548 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tamura, M., Kanno, Y., Chuma, S., Saito, T., Nakatsuji, N.: "Pod-1/Capsulin shows a sex-and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-1"Mech. Devel.. 102. 135-144 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Noce, S.Okamoto, N.Tsunekawa.: "Vasa homolog genes in mammalian germ cell development"Cell Struc. & Func.. 26. 131-136 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hasegawa, K., Nakatsuji, N.: "Insulators prevent transcriptional interference between two promoters in a double gene construct for transgenesis"FEBS Lett.. 520. 47-52 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamamoto, M., Matsui, Y: "Testis-specific expression of a novel mouse defensin-like gene, Tdl"Mech. Dev.. 116. 217-221 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kono, T., Sotomaru, Y., L, Dandolo.: "Mouse parthenogenetic embryos with mono-allelic H19 expression can develop to day 17.5 of gestation."Dev. Biol.. 243. 294-300 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Inoue, K., Kohda, T., Lee, J., Ogonuki, N., Mochida, K., Noguchi, Y., Tanemura, K., Kaneko-Ishino, T., Ishino, F., Ogura, A.: "Faithful expression of imprinted genes in cloned mice"Science. 295. 297 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanatsu-Shinohara, M., Ogura, A., Ikegawa.M., Inoue, K., Ogonuki, N., Tashiro, K., Toyokuni, S., Honjo, T., Shinohara, T.: "Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice"Proc. Natl. Acad. Sci. USA. 99. 1383-1388 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ogonuki.N., Inoue, K., Yamamoto, Y., Noguchi.Y., Tanemura, K., Suzuki, O., Nakayama, H., Doi, K., Ohtomo, K., Satoh, M., Nshida, A., Ogura, A.: "Early death of mice cloned from somatic cells"Nat Genet. 30. 253-254 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tanaka, K., Tamura, H., Tanaka, H., Katoh, M., Futamata, Y., Seki, N., Nishimune, Y, Hara, T.: "Spermatogonia-dependent expression of testicular genes in mice"Dev. Biol.. 246. 466-479 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tadokoro, Y., Yomogida, K., Ohta, H., Tohda, A., Nishimune, Y: "Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway"Mech. Dev.. 113. 29-39 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujii, T., Tamura, K., Masai, K., Tanaka, H., Nishimune, Y., Nojima, H.: "Use of stepwise subtraction to comprehensively isolate mouse genes whose transcription is upregulated during spermiogenesis"EMBO Rep.. 3(4). 367-372 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Koike, K., K.Hone, H.Fukuyama, G.Kondoh, S.Nagata, J.Takeda: "Efficient biallelic mutagenesis with Crc/loxP-mediated inter-chromosomal recombination"EMBO reports. 3-5. 433-437 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kanno,Y., Tamura, M., Chuma, S., Sakurai, T., Machida, T. and Nakatsuji, N.: "A cystatin-related gene, testatin/cresp, shows male-specific expression in germ and somatic cells from the initial stage of murine gonadal sex-differentiation"Int. J. Dev. Biol. 43. 777-784 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tada, T., Obata, Y., Tada, M., Goto, Y., Nakatsuji, N., Tan, S.-S., Kono, T. and Takagi, N.: "Imprint switching for non-random X-chromosome inactivation during mouse oocyte growth"Development. 127. 3101-3105 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Huang, Z., Tamura, M., Sakurai, T., Chuma, S., Saito, T., and Nakatsuji, N.: "In vivo transfection of testicular germ cells and transgenenis by using the mitochondrially localized jellyfish fluorescent protein gene"FEBS Lett.. 487. 248-251 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S.S.Tanaka, Y. Toyooka, R. Akasu, Y. Katoh-Fukui, Y. Nakahara, R. Suzuki, M. Yokoyama and T. Noce: "Mouse homolog gene to Drosophila Vasa is required for the development of male germ cells"Genes & Dev.. 14. 841-853 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Toyooka, N. Tsunekawa, Y. Takahashi, Y. Matsui, M. Satoh and T. Noce.: "Expression and intracellular localization of mouse Vasa-homolog protein during germ cell development"Mech. Dev.. 93. 139-149 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chuma, S. and Nakatsuji, N.: "Autonomous transition into meiosis of mouse fetal germ cells in vitro and its inhibition by gp130-mediated signaling"Devel. Biol.. 229. 468-479 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakatsuji, N. and Chuma, S.: "Differentiation of mouse primordial germ cells into female or male germ cells"Int. J. Dev. Biol.. 45. 541-548 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamura, M., Kanno, Y., Chuma, S., Saito, T, and Nakatsuji, N.: "Pod-1/Capsulin shows a sex- and stage-dependent expression pattern in the mouse gonad development and represses expression of Ad4BP/SF-l"Mech. Devel.. 102. 135-144 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T. Noce, S. Okamoto, and N. Tsunekawa: "Vasa homolog genes in mammalian germ cell development"Cell Struc. & Func.. 26. 131-136 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hasegawa, K. and Nakatsuji, N.: "Insulators prevent transcriptional interference between two promoters in a double gene construct for transgenesis"FEBS Lett.. 520. 47-52 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamamoto, M, and Matsui, Y.: "Testis-specific expression of a novel mouse defensin-like gene, Tdl"Mech. Dev.. 116. 217-221 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kono, T., Sotomaru, Y., L. Dandolo: "Mouse parthenogenetic embryos with mono-allelic H19 expression can develop to day 17.5 of gestation"Dev. Biol. 243. 294-300 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Inoue, K., Kohda, T., Lee, J., Ogonuki, N., Mochida, K., Noguchi, Y., Tanemura, K., .Kaneko-Ishino, T., Ishino, K, and Ogura, A.: "Faithful expression of imprinted genes in cloned mice"Science. 295. 297 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kanatsu-Shinphara, M. Ogura, A., Ikegawa, M., Inoue, K., Ogonuki, N., Tashiro, K., Toyokuni, S., Honjo, T., and Shinohara, T.: "Adenovirus-mediated gene delivery and in vitro microinsemination produce offspring from infertile male mice"Proc. Natl. Acad. Sci. USA. 99. 1383-1388 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ogonuki, N., Inoue, K., Yamamoto, Y,, Noguchi, Y., Tanemura, K., Suzuki, O., Nakayama, H., Doi, K., Ohtomo, K., Satoh, M., Nishida, A., and Ogura, A.: "Early death of mice cloned from somatic cells"Nat Genet. 30. 253-254 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tanaka, K., Tamura, H., Tanaka, H., Katoh, M., Futamata, Y., Seki, N.,Nishimune, Y. and Hara, T.: "Spermatogonia-dependent expression of testicular genes in mice"Dev. Biol.. 246. 466-479 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tadokoro, Y., Yomogida, K., Ohta, H., Tohda, A. and Nishimune, Y.: "Homeostatic regulation of germinal stem cell proliferation by the GDNF/FSH pathway"Mech. Dev.. 113. 29-39 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujii, T., Tamura, K.,Masai,K., Tanaka,H., Nishimune, Y. and Nojima, H.: "Use of stepwise subtraction to comprehensively isolate mouse genes whose transcription is upregulated during spermiogenesis"EMBO Rep. 3(4). 367-372 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Koike, K., K. Horie, H. Fukuyama, G. Kondoh, S. Nagata, and T. Takeda: "Efficient biallelic mutagenesis with Cre/loxP-mediated inter-chromosomal recombination"EMBO reports. 3-5. 433-437 (2002)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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