2000 Fiscal Year Final Research Report Summary
Analysis of pathophysiology in acute pancreatitis from the stand point of SIRS and CARS
| Project/Area Number |
11307020
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| Research Category |
Grant-in-Aid for Scientific Research (A).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Kumamoto University |
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Principal Investigator |
OGAWA Michio Kumamoto University School of Medicine Professor, 医学部, 教授 (30028691)
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| Co-Investigator(Kenkyū-buntansha) |
HIROTA Masahiko Kumamoto University School of Medicine, Assistant, 医学部・附属病院, 助手 (80284769)
MORI Katsutaka Kumamoto University College of Medical Science Professor, 医療技術短期大学部, 教授 (10040213)
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| Project Period (FY) |
1999 – 2000
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| Keywords | acute pancreatitis / SIRS / CARS / organ dysfunction / infection / cytokine / サイトカイン / 好中球 |
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| Research Abstract |
Acute pancreatitis is a potentially fatal disease. Most patients develop systemic inflammatory response syndrome (SIRS), which is induced by inflammatory cytokines. In this condition, neutrophils primed by preceding inflammatory insult are further activated to cause distant organ dysfunction if the second attack-like infection occurs. Alternatively, patients with severe inflammatory insults also undergo an anti-inflammatory phase, the compensatory anti-inflammatory response syndrome (CARS). This condition is characterized by the production of anti-inflammatory cytokines and, as a result, suppression of cytokine response, which may result in immune suppression. After induction of severe pancreatitis, cytokine production was markedly suppressed for a while. In this CARS condition, production of IL-2 by splenocyte decreased and mortality rate after induction of bacterial peritonitis increased. These results suggest that both excessive cytokine response in SIRS and altered defense system in CARS may result in the development of distant organ dysfunction.
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[Publications] Liang J, Yamaguchi Y, Matsumura F, Okabe K, Akizuki E, Matsuda T, Ohshiro H, Nakano S, Ishihara K, Yamada S, Ogawa M: "The novel carboxamide derivative (IS-741) attenuates lung injury in rats with cerulein-induced pancreatitis complicated by sepsis."Dig Dis Sci. 44. 341-349 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Hirota M, Nozawa F, Okabe A, Shibata M, Beppu T, Shimada S, Egami H, Yamaguchi Y, Ikei S, Okajima K, Okamoto K, Ogawa M: "Relationship between plasma cytokine concentration and multiple organ failure in patients with acute pancreatitis."Pancreas. 21. 141-146 (2000)
Description
「研究成果報告書概要(欧文)」より
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