2001 Fiscal Year Final Research Report Summary
Pathogenesis and origin of tick-borne encephalitis virus isolated in Japan
| Project/Area Number |
11460143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Applied veterinary science
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| Research Institution | HOKKAIDO UNIVERSITY |
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Principal Investigator |
TAKASHIMA Ikuo Hokkaido Univ., Grad. School of Vet. Med., Prof., 大学院・獣医学研究科, 教授 (30002083)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kenichi Hokkaido Inst, of Pub. Health., Sect., of Med Zool, Head, 疫学部, 科長
IWASAKI Takuya Nagasaki Univ., Inst. of Trop. Med., Prof., 熱帯医学研究所, 教授 (90146027)
KARIWA Hiroaki Hokkaido Univ., Grad. School of Vet. Med., Assoc. Prof., 大学院・獣医学研究科, 助教授 (70224714)
MIZUTANI Tetsuya Hokkaido Univ., Grad. School of Vet. Med., Instr., 大学院・獣医学研究科, 助手 (70281681)
MARUYAMA Tsutomu Azabu Univ., Dept. Env. Health., Prof., 環境保健部, 教授 (50239159)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Viral encephalitis / Tick-borne encephalitis / Origin / Pathogenicity |
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| Research Abstract |
We conducted epidemiclogical study to specify the endemic area of tick-borne encephalitis (TBE), evaluated the pathogenicity of TBE virus Hokkaido strain and tested the efficacy of European TBE vaccine to Hokkaido TBE virus strain. We also performed phylogenetic study of TBE virus Hokkai strains to estimate the origin.
The results showed that TBE virus distribute in southern part of Hokkaido from the positive antibody results in dog and horse sera. Reservoir animals of TBE virus in Hokkaido were found to Clethrionomys rufocanus and Apodemus speciosus from virus isolation result. TBE virus Hokkaido strains possessed common pathogenicity shared among TBE virus strains. TBE virus Hokkaido strain diverged from ancestor virus in Far East several hundred years ago. Another subtype of TBE virus Siberian subtype was found to distribute in Siberian area of Russia. European type TBE virus vaccine was found to be efficacious to TBE virus Hokkaido, Far Eastern and Siberian strains. Monoclonal antibodies against TBE virus Hokkaido strain were produced and found to be useful for diagnosis.
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Research Products
(21 results)
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[Publications] Chiba, N., Iwasaki, T., Mizutani, T., Kariwa, H., Kurata, T., Takashima, I.: "Pathogenicity of tick-borne encephalitis virus isolated in Hokkaido, Japan in mouse model"Vaccine. 17. 779-787 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takeda, T., Ito, T., Osada, M., Takahashi, K., Takashima, I.: "Isolation of tick-borne encephalitis virus from wild rodents and a seroepizootiologic survey in Hokkaido, Japan"Am. J. Trop. Med. Hyg.. 60. 287-291 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Chiba, N., Osada, M., Komoro, K., Mizutani, T., Kariwa, H., Takashima, I.: "Protection against tick-borne encephalitis virus isolated in Japan by active and passive immunization"Vaccine.. 17. 1532-1539 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hayasaka, D., Suzuki, Y., Kariwa, H., Ivanov, L., Volkov, V., Demenev, V., Mizutani, T., Gojobori, T., Takashima. I.: "Phylogenetic and virulence analysis of tick-borne encephalitis viruses from Japan and far-eastern Russia"J. Gen. Virol.. 80. 3127-3135 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hayasaka, D., Ivanov, L., Leonova, G.N., Goto, A., Yoshii, K., Mizutani, T., Kariwa, H., Takahima, I.: "Distribution and characterization of tick-borne encephalitis viruses from Siberia and Far-eastern Asia"J. Gen. Virol.. 82. 1319-1328 (2001)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Hayasaka, D., Goto, A., Yoshii, K., Mizutani, T., Kariwa, H., Takashima, I.: "Evaluation of European tick-borne encephalitis virus vaccine against recent Siberian and Far-eastern subtype strains"Vaccine. 19. 4774-4779 (2001)
Description
「研究成果報告書概要(欧文)」より
