2000 Fiscal Year Final Research Report Summary
Functional Analysis of the NMDA-recepter-APC-DLG-Complex.
| Project/Area Number |
11470039
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | The University of Tokyo |
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Principal Investigator |
AKIYAMA Testu Institute of Molecular and Cellular Biosciences, The University of Tokyo Professor, 分子細胞生物学研究所, 教授 (70150745)
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| Project Period (FY) |
1999 – 2000
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| Keywords | NMDA receptor / Tumor suppressor / APC / PSD-95 / SPAL / synapse / post synaptic density / learning |
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| Research Abstract |
The synaptic protein PSD95/SAP90 interacts with ion channels such as the N-methyl-D-aspartate-receptor (NMDA-R) via its PDZ domain, and is involved in their clustering. Moreover, it interacts with signaling molecules and plays an important role in coupling NMDA-R to pathways that control synaptic plasticity and learning. We found that PSD-95 is associated with the adenomatous polyposis coli (APC) tumor suppressor protein, Rap1-specific GAP (SPAL), LGN and tyrosine kinase Fyn. Our findings raise the possibility that these molecules are involved in the regulation of NMDA-R clustering and/or NMDA-R-mediated signal transduction.
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Research Products
(40 results)
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[Publications] F.Hamada, Y.Tomoyasu, Y.Takatsu, M.Nakamura, S.Nagai, A.Suzuki, F.Fujita, H.Shibuya, K.Toyoshima, N.Ueno & T.Akiyama: "Negative regulation of Wingless signaling by D-Axin, a Drosophila homologue of Axin."Science. 283. 1739-1742 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] K.Tago, T.Nakamura, M.Nishita, J.Hyodo, S.Nagai, Y.Murata, S.Adachi, S.Ohwada, Y.Morishita, H.Shibuya and T.Akiyama: "Inhibition of Wnt signaling by ICAT, a Novel b-catenin-interacting Protein."Gense Dev.. 14. 1741-1749 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Kohu, K., Roy, B.C., Kuroda, T., Kakinuma, N., Akiyama, T.and Senda, T.: "Localization of the Novel GAP Family Protein SPAL in Epithelial Cells."Acta Histochem.Cytochem.. (in press).
Description
「研究成果報告書概要(欧文)」より
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