2000 Fiscal Year Final Research Report Summary
Targets as the malarial infection and the attack of extrathymic T cells : MHC^+ erytherocytes in the bone marrow
| Project/Area Number |
11470066
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| Research Category |
Grant-in-Aid for Scientific Research (B).
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
寄生虫学(含医用動物学)
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
ABO Toru Niigata University, Faculty of Medicine, School of Medicine, Professor, 医学部, 教授 (30005079)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Hisami Niigata University Faculty of Medicine, School of Medicine, Lecturer, 医学部, 講師 (50143756)
SEKIKAWA Hiroho Niigata University Faculty of Medicine, School of Medicine, Associate Professor, 医学部, 助教授 (50018694)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Malaria / Plasmodium / Liver / Extrathymic T cells / TCR^<int> / NKT cells / Memory / NK1.1 subset |
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| Research Abstract |
Mice were infected with Plasmodium(P.)yoelii, blood-stage parasites. Both the liver and spleen were the sites of inflammation during malarial infection at the beginning of day 7. The major expanding cells were found to be NK1.1 intermediate αβTCR(αβTCR^<int>)in the liver and spleen, although the population of NK1.1^+αβTCR^<int> cells remained constant or slightly increased. These TCR^<int> cells are of extrathymic origin or are generated by an alternative intrathymic pathway, and are distinguished from conventional T cells of thymic origin. During malarial infection, the population of conventional T cells did not increase at all. TCR^<int> cells purified from the liver of mice which had recovered from P.yoelii infection protected mice from malaria when they were transferred into 6.5 Gy-irradiated mice. Interestingly, the immunity against malaria seemed to disappear as a function of time after the recovery. Namely, mice which had recovered from malaria one year previously again became susceptible to malarial infection. The present results suggest that TCR^<int> cells are intimately associated with the protection against malarial infection and, therefore, that the mice which had recovered from malaria one year previously lost such immunity.
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[Publications] Suzuki, S., Sugahara, S., Shimizu, T., Tada, T., Minagawa, M., Maruyama, S., Watanabe, H., Saito, H., Ishikawa, H., Hatakeyama K.and Abo, T.: "Low level of mixing of partner cells seen in extrathymic T cells in the liver and intestine of parabiotic mice : Its biological implication."Eur.J.Immunol.. 28. 3719-3729 (1998)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Yamashita, T., Miyata, H., Miyaji, C., Watanabe, H., Abo, T., kobayakawa, T., Kaneko, A.and Sendo, F.: "CD4^+ and/or γδ^+T cells in the liver spontaneously produce IL-4 in vitro during the early phase of Leishmania major infection in susceptible BALB/c mice."Acta Tropica. 73. 109-119 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Kawamura, H., Kawamura, T., Kokai, Y., Mori, M., Matsuura, A., Oya, H., Honda, S., Suzuki, S., Weerashinghe, A., Watanabe, H and Abo. T.: "Expansion of extrathymic T cells as well as granulocytes in the liver and other organs of G-CSF transgenic mice : Why they lost the ability of hybrid resistance."J.Immunol.. 162. 5957-5964 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Maruyama, S., Tsukahara, A., Suzuki, S., Tada, T., Minagawa, M., Watanabe, H., Hatakeyama, K.and Abo, T.: "Quick recovery in the generation of self-reactive CD4^<low> NKT cells by an alternative intrathymic pathway when restored from acute thymic atrophy."Clin.Exp.Immunol.. 117. 587-595 (1999)
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「研究成果報告書概要(欧文)」より
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[Publications] Miyaji, C., Watanabe, H., Toma, H., Akisaka, M., Tomiyama, K., Sato, Y.and Abo, T.: "Functional alteration of granulocytes, NK cells, and natural killer T cells in centenarians."Human Immunol. 61. 908-916 (2000)
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「研究成果報告書概要(欧文)」より
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[Publications] Weerasinghe, A., Sekikawa, H., Watanabe, H., Mannoor, M.K., Morshed S.R.M., Halder, R.C., Kawamura, T., Kosaka, T., Miyaji, C., Kawamura, H., Seki, Sand Abo, T.: "Association of intermediate T cell receptor cells, mainly their NK1.1 subset, with protection from malaria."Cell.Immunol.. 207. 28-35 (2001)
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「研究成果報告書概要(欧文)」より
