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2000 Fiscal Year Final Research Report Summary

Placental CRH and opioid receptor gene expression produced by physical environmental stress and its physiological significance

Research Project

Project/Area Number 11470094
Research Category

Grant-in-Aid for Scientific Research (B).

Allocation TypeSingle-year Grants
Section一般
Research Field Hygiene
Research InstitutionKanazawa University

Principal Investigator

NAKAMURA Hiroyuki  Kanazawa University, School of Medicine, Associate professor, 医学部, 助教授 (30231476)

Co-Investigator(Kenkyū-buntansha) NALAJIMA Madoka  Kanazawa University, School of Medicine, Instructor, 医学部, 助手 (10324071)
OGINO Keiki  Kanazawa University, School of Medicine, Professor, 医学部, 教授 (70204104)
NAGASE Hirofumi  Kanazawa University, School of Medicine, Assistant professor, 医学部, 講師 (00251918)
Project Period (FY) 1999 – 2000
Keywordsmicrowaves / prostaglandin / uteroplacental blood flow / endothelin / CRH / heat / β-endorphin / pregnancy
Research Abstract

To clarify the involvement of CRH and opioid system in the uteroplacental circulation in the pregnant rats exposed to heat, we examined the effects of heat and intravenous (iv) administration of CRH receptor antagonist α-helical CRH (9-41) on the uteroplacental blood flow (BF) as well as blood CRH, and blood and placental β-endorphin (β EP) in pregnant rats. Heat did not change uterine BF in virgin rats, but reduced uteroplacental BF in pregnant rats. The reduced uteroplacental BF during heat in pregnant rats was reversed by the administration of α-helical CRH.Independent of the status of pregnancy, heat increased blood CRH, which was not reversed by α-helical CRH.Although heat did not change placental βEP, α-helical CRH reduced blood and placenta βEP in pregnant rats. Next, we examined the effects of iv administration of endothelin (ET) receptor antagonist bosentan and a cyclooxygenase inhibitor indomethacin on the uteroplacental BF as well as placental PGE_2 F_<2α> systems in heat exposed or non-heat exposed pregnant rats. The administration of bosentan or indomethacin did not change the uteroplacental BF in non-heat exposed pregnant rats. The administration of bosentan or indomethacin reversed the reduction in the uteroplacental BF during heat. Heat did not change placental PGE_2 system, but increased placental PGF_<2α> system in pregnant rats, which was reversed by bosentan or indomethacin. These results suggest that the uteroplacental circulatory disturbance during heat is mediated by CRH, possibly through the involvement of CRH receptor in rat placenta. The placental opioid system seems unlikely to be involved in the mediation of uteroplacental circulation. The activations of placental ET receptor and PGF_<2α> system seem to be involved in the uteroplacental circulatory disturbances produced by heat. PGF_<2α> system activated by heat may be involved in the vasoconstricting effects of ETA and ETB receptor during heat exposure.

  • Research Products

    (7 results)

All Other

All Publications (7 results)

  • [Publications] Nakamura H,Nagase H,Ogino K,Hatta K and Matsuzaki I: "Heat produces uteroplacental circulatory disturbance in pregnant rats through action of corticotropin releasing hormone (CRH)"Placenta. 21. 510-515 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H,Nagase H,Ogino K,Hatta K and Matsuzaki I: "Uteroplacental circulatory disturbance in pregnant rats exposed to microwaves through actions of prostaglandin F2α"Reprod Toxicol. 14. 235-240 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H,Nagase H,Ogino K,Hatta K,and Matsuzaki I: "Involvement of central, but not placental corticotropin releasing hormone (CRH) in heat stress-induced immunosuppression during pregnancy"Brain Behav Immun. (in print).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakamura H, Nagase H, Ogino K, Hatta K, Matsuzaki I: "Heat produces uteroplacental circulatory disturbance in pregnant rats through action of corticotropin releasing hormone (CRH)."Placenta. 21. 510-5 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H, Nagase H, Ogino K, Hatta K, Matsuzaki I: "Uteroplacental circulatory disturbance mediated by prostaglandin f2alpha in rats exposed to microwaves."Reprod Toxicol. 14. 235-40 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshida M, Shirao Y, Asai H, Nagase H, Nakamura H, Okazawa T, Kondo K, Takayanagi TH, Fujita K, Akao N: "A retrospective study of ocular toxocariasis in Japan : correlation with antibody prevalence and ophthalmological findings of patients with uveitis."J Helminthol. 73. 357-61 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakamura H, Nagase H, Ogino K, Hatta K, and Matsuzaki I: "Involvement of central, but not placental corticotropin releasing hormone (CRH) in heat stress-induced immunosuppression during pregnancy"Brain Behav Immun. (in print).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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