2001 Fiscal Year Final Research Report Summary

Studies on human health assesement based upon a dose-response relationship between human and harmful substanus in the emvironment

Research Project

Project/Area Number	11470098
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Hygiene
Research Institution	Saitama Medical School
Principal Investigator	WADA Osamu Saitama medical school, Faculty of Medicine, Professor, 医学部, 教授 (60009933)
Co-Investigator(Kenkyū-buntansha)	YANAGISAWA Hiroyuki Saitama medical school, Faculty of Medicine, Associate professor, 医学部, 助教授 (10200536)
Project Period (FY)	1999 – 2001
Keywords	Dioxin / Dose-response relationship / health assessment / 発癌
Research Abstract	The present study was designed to establish human health assessment based on a dose-response relationship between dioxin and humans. The level of dioxin in the lever causing liver cancer was 24 ng/g in rats. Also, the exposure level of dioxin leading to some influence was 10 ng/kg/day in rats. The level of dioxin did not reach the two values in humans. The incidence of all cancers, lung cancer and sarcoma derived from soft tissues was not defferenciated from the background incidence when examined in the group exposed to high levels of dioxin using the dose-response relationship established. Thus, the rsults of the present study demonstrate that the carcinogenicity of dioxin is not at present detected even in the group exposed to high levels of dioxin. The methodology established in the present study may be an available tool in human health assessment of dioxin.

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