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2002 Fiscal Year Final Research Report Summary

Studies of effect of air pollutions on allergic rhinitis and conjunctivitis and their mechanisms

Research Project

Project/Area Number 11470116
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Public health/Health science
Research InstitutionNational Institute for Environmental Studies

Principal Investigator

KOBAYASHI Takahiro  National Institute for Environmental Studies Environmental Health Sciences Division Deputy Director, 環境健康研究領域, 上席研究官 (50124342)

Co-Investigator(Kenkyū-buntansha) HOSOKAWA Tomokazu  Hoshi University Drug Delivery Research Assistant professor, 薬学教育センター, 助教授 (00101577)
Project Period (FY) 1999 – 2002
Keywordsdiesel exhaust / NO_7 / O_3 / nasal allergy / allergic conjunctivitis / IgG antibody / eosinophils / allergic responses
Research Abstract

This project designed to elucidate the effects of exposure to diesel exhaust NO2 or O3 on allergic pollenosis ,such as nasal allergy, and allergic conjunctivitis induced by repeated antigen administration, the lowest observed adverse effect level, and the mechanisms. Effects of DE containing 0.1. 0.3, 1.0 mg/m3 particles on nasal allergy, and allergic conjunctivitis are investigated using indices such as sneezes, nasal secretion, score of the symptoms of conjunctivitis, vascular permeability, OA specific IgG and IgE titer, infiltration of eosinophils in epithelium and subepithelium of nasal mucosa and conjunctiva, and responsiveness to physical stimuli or histamine. Exposure to DE enhances nasal and conjunctival allergic resposes, OA specific IgG and IgE titer, infiltration of eosinophils, responsiveness to histamine dose dependent manner. The lowest observed adverse effect level is DE containing 0.1 mg/m3-particles. Effects of 0.1, 0.3, 1.0, 3.0, 10 ppm NO2 on nasal allergy, and allergic conjunctivitis are investigated using same indices used in DE. Exposure to NO2 enhances nasal and conjunctival allergic resposes, infiltration of eosinophils, dose dependent manner. The lowest observed adverse effect level of NO2 is 1 ppm. Effects of 0.1 0.2. 0.4, 0.6 ppm 03 on nasal allergy, and allergic conjunctivitis are investigated using same indices used in DE. Exposure to O3 enhances nasal and conjunctiva! allergic resposes, OA specific IgG titer, infiltration of eosinophils, responsiveness to physical stimuli dose dependent manner. The lowest observed adverse effect level of03 is 0.4 ppm.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] E.Koike, T.Kobayashi et al.: "cDNA Microarray analysis of gene expression in rat alveolar macrophages in response to organic extract of diesel exhaust particles"Toxicol.Sci.. 67. 241-246 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Koike, T.Kobayasi et al.: "Ozone exposure enhances expression of cell-surface molecules associated with antigen-presenting on bronchoalveolar lavage cells in rats"Toxicol.Sci.. 63. 115-124 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.K.Iijima, T.Kobayashi et al.: "Exposure to ozone aggravates nasal allergy-like Symptoms in guinea pigs"Toxicol. Letters. 123. 77-85 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Koike, T.Kobayashi et al.: "Effect of exposure to nitrogen dioxide on alveolar macrophage-mediated Immunosupressive in rats"Toxicol. Letters. 121. 135-143 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Kobayashi: "Exposure to diesel exhaust aggravates nasal allergic in reaction in guinea pigs"Am. J. Respir. Crit., Care Med.. 162. 352-356 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Koike, T.Kobayashi et al.: "Effect of aging on nitric oxide production by rats alveolar macrophages"Exp. Gerontol. 34. 889-894 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Hiruma, T.Kobayashi et al.: "Effect of diesel exhaust on guinea pig nasal mucosa"Ann. Otl. Rhinal. Laryngol.. 108. 582-588 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E.Koike, T.Kobayashi et al.: "Mechanisms of ozone-inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage-mediated immunosuppressive activity in rats"J. Leukoc. Biol.. 66. 75-82 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林隆弘: "喘息と外的要因大気汚染との関連"臨床雑誌「内科」. 90. 607-610 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林隆弘, 細川友和等: "花粉症の発症と大気汚染"アレルギー科. 12. 331-337 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林隆弘: "SMP(浮遊粒子状物質)"安全衛生のひろば. 12. 46-47 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 隆弘: "入門 大気汚染微小粒子の環境・健康影響"横山栄二, 内山巌雄 編. 199 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] E. Koike, T, Kobayashi et al.: "cDNA Microarray Analysis of gene expression in rat alveolar macro-phages in response lo organic extract of diesel exhaust particles."Toxicol.Sci.. 67. 241-246 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Koike, T. Kobayashi et al.: "Ozone exposure enhances expression of cell-surface molecules asso-ciated with antigen-presenting activity on bronchoa-Iveolar lavage cells in rats."Toxicol.Sci.. 63. 115-124 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.K lijima, T.Kobayashi et al.: "Exposure lo ozone aggravates nasal allergy-like symptoms in guinea pigs."Toxicol.Lellers. 123. 77-85 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Koike. T. Kobayashi et al.: "Effect of exposure to nitrogen dioxide on alveolar macrophage-mediated immunosuppressive activity in rats."Toxicol.Letters. 121. 135-143 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Kobayashi: "Exposure to diesel exhaust aggr-avates nasal allergic reaction in guinea pigs."Am. J. Respir. Crit. Care Med.. 162. 352-356 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Koike, T. Kobayashi et al.: "Effect of aging on nitric oxide production by rat alveolar inacrophages."Exp.GerontoI. 34. 889-894 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Hiruma, T. Kobayashi et al.: "Effect of diesel exhaust on guinea pig nasal mucosa."Amm. Otl. Rhinal. Laryngol.. 108. 582-588 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] E. Koike, T. Kobayashi et al.: "Mechanisms of ozone-inhibitory effect of bronchoalveolar lavage fluid on alveolar macrophage-mediated immune-suppressive activity in rats."J. Leukoc. Biol.. 66. 75-82 (1999)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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