2001 Fiscal Year Final Research Report Summary
Molecular mechanism in Sjogren's syndrome
| Project/Area Number |
11470123
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
内科学一般
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| Research Institution | University of Tsukuba |
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Principal Investigator |
SUMIDA Takayuki University of Tsukuba, Department of Internall Medicine, Professor, 臨床医学系, 教授 (00183054)
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| Project Period (FY) |
1999 – 2001
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| Keywords | Sjogren's syndrome / Tcell receptor / T cell epitope / g-amylase / analogpeptide |
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| Research Abstract |
The purpose of the present study is to clarify the mechanism in the generation of Sjogren's syndrome (SS), T cell receptor (TCR) genes in T cells infiltrating in labial salivary glands, lacrymal glands, and interstitium of kidneys have been analyzed by molecular biology technology. The results showed thatT cells in organs recognized antigens in the context of HLA molecule, suggesting the antigen-driven stimulation. Moreover, the antigens for T cells in salivary glands have been examined by several methodsatthe level ofamino acids. We have obtained the following two findings. 1) Salivary type a-amylase function as gland-specific autoantigen recognized by T cells in the salivary glands. 2) One of T'cell epitopes of T cells in salivary glands is NPFRPWWERYQPV (AA68-80) of a-amylase. In near future, autoreactive T cells might be induced into anergy by the vaccination of analog peptides of a-amylase, resulting in the regulation of SS in the antigen-specific fashion.
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