2001 Fiscal Year Final Research Report Summary
RESEARCHES ON THE NOVEL MECHANISMS OF NEUROTRANSMISSION VIA NITRIC OXIEG IN THE SMOOTH MUSCLES OF THE GENITO-URINMY ORGANS.
| Project/Area Number |
11470334
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | YAMANASHI MEDICAL UNIVERSITY |
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Principal Investigator |
TAKEDA Masayuki YAMANASHI MEDICAL UNIVERSITY, UROLOGY PROF. ESSOR, 医学部, 教授 (80197318)
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| Co-Investigator(Kenkyū-buntansha) |
TSUCHIDA Takayuki YAMANASHI MEDICAL UNIVERSITY, UROLOGY Lecturer, 医学部, 助手 (30217327)
MAEZAWA Hideaki YAMANASHI MEDICAL UNIVERSITY, UROLOGY ASSIST. PROF, 医学部, 講師 (50190294)
TANABE Nobuaki YAMANASHI MEDICAL UNIVERSITY, UROLOGY ASSOCIATE PROF, 医学部, 助教授 (20163602)
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| Project Period (FY) |
1999 – 2001
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| Keywords | KEY WORDS / NITRIC OXIDE (NO) / NITRIC OXIDE SYNTHASE (NOS) / CAVEOLIN / NERVE GROWTH FACTOR RECEPTOR ( NGFR ) / PENIS / PENILE CORPOREAL BODY / NGFR |
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| Research Abstract |
RESEARCHES ON THE LOCALIZATION OF, NITRIC OXIDE SYNTHASE (NOS) AND ITS INHIBITORY PROTEINS, CAVEOLINS, IN THE HUMAN GENITO-URINARY ORGANS.
1) LOCALIZATION OF CAVEOLINS AND NOS IN THE HUMAN PENILE CAVERNOUS SMOOTH
MUSCLE : CAVEOLIN-1 LOCALIZED IN CORPUS CAVERNOUS SMOOTH MUSCLE, ENDOTHELIAL CELLS OF CEVERNOUS BODY, AND ADVENTITIA OF PENILE VESSLES. CAVEOLIN-3 LOCALIZED IN THE MEDIA AND ADVENITIA OF PENILE VESSELS, AND THE DISTRIBUTION WAS SIMILAR THOSE OF NADPH-DIAPHORASE STAINING. LNGFR-POSITIVE FIBERS ABUNDANTLY LOCALIZED IN VASCULAR WALL AND CAVERNOUS BODY, AND ITS DISTRIBUTION WAS DIFFERENT FROM NOS. THESE DATA SUGGESTS THAT LNGFR-POSITIVE NERVE FIBERS ARE DIFFERENT FROM NOS-POSITIVE NERVES, AND MAY BE AFFERENT NERVES.
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