• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

2001 Fiscal Year Final Research Report Summary

Design and Syntheses of Biologically Functional Molecules Based on the Mechanisms of Life

Research Project

Project/Area Number 11470469
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Chemical pharmacy
Research InstitutionOsaka University

Principal Investigator

IMANISHI Takeshi  Graduate School of Pharmaceutical Sciences, Osaka University, Professor, 薬学研究科, 教授 (40028866)

Co-Investigator(Kenkyū-buntansha) OBIKA Satoshi  Graduate School of Pharmaceutical Sciences, Osaka University, Assistant Professor, 薬学研究科, 助手 (80243252)
MIYASHITA Kazuyuki  Graduate School of Pharmaceutical Sciences, Osaka University, Associate Professor, 薬学研究科, 助教授 (10166168)
DOI Takefumi  Graduate School of Pharmaceutical Sciences, Osaka University, Professor, 薬学研究科, 教授 (00211409)
Project Period (FY) 1999 – 2001
KeywordsNucleoside Analogs / Oligonucleotides / Antisence / Pyridoxal model compounds / unnatural amino acids / Chemiluminescence / Cationic liposome / Gene transfection
Research Abstract

We studied the four subjects and obtained the results shown below:
(1) We have succeeded to synthesize 2'-0,4'-C-methylene bridged nucleic acid analogs (BNAs) and oligonucleotides containing the BNA (BNA-ODNs). The BNA-ODNs were found to have more effective duplex and triplex forming ability than natural ODNs and modified ODNs ever reported. Comparison of various properties of BNA-ODNs with those of natural ODNs and S-ODNs showed that the BNA-ODNs have an excellent antisense ability.
(2). We have designed and synthesized novel chiral vitamin B_6 model compounds having a chiral ansa-structure and/or a chiral ionophore structure, which were found to be effective for asymmetric α-alkylation ofα-amino esters and petides at the N-terminal position. Catalytic β-replacement reaction of a Ser derivative with thiols was also successfully achieved by employing the pyridoxal model compounds.
(3) We have synthesized fire-fly luciferin analogs having a heterocyclic structure in place of the benzothiazole structure of the fire-fly luciferin molecule, and studied their bioluminescent and chemiluminescent activities. As a result, it was found that the benzimidazole derivative shows effective light-emmisio by treatment with luciferase, while the benzoxazole derivative is effective for chemiluminescent induced by oxidative treatment.
(4) We have synthesized cationic lipid having a symmetrical structure, and studied gene transfection activity of liposome prepared from the lipid. As a consequence, it was found that the liposome composed of the symmetrical lipid, which was more easily prepared than that having an unsymmetrical structure, is low toxic and effective for gene transfection.

  • Research Products

    (64 results)

All Other

All Publications (64 results)

  • [Publications] S.Obika, W.Yu, A.Shimoyama, T.Uneda, T.Minami, K.Miyashita, T.Doi, T.Imanishi: "Properties of cationic liposomes composed of cationic lipid YKS-220 having an ester linkage : adequate stability, high transfection efficiency, and low cytotoxicity"Biol. Pharm. Bull.. 22・2. 187-190 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] W.Yu, A.Shimoyama, T.Uneda, S.Obika, K.Miyashita, T.Doi, T.Imanishi: "Gene transfer mediated by YKS-220 cationic particles : covenient and efficient gene delivery reagent"J. Biochem. 125・6. 1034-1038 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, K.Morio, Y.Hari, T.Imanishi: "Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides"Bioorg. Med. Chem. Lett. 9・4. 515-518 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, J.Andoh, T.Sugimoto, K.Miyashita, T.Imanishi: "Synthesis of a conformationally locked AZT analogue, 3'-azido-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine"Tetrahedron Lett.. 40・35. 6465-6468 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, K.Morio, Y.Hari, T.Imanishi: "Facile synthesis and conformation of 3'-O,4'-C-methyleneribonucleosides"Chem. Commun.. 23. 2423-2424 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Miyashita, H.Miyabe, K.Tai, C.Kurozumi, H.Iwaki, T.Imanishi: "Chiral environment specifically induced by metal ion : asymmetric α-alkylation of α-amino esters using pyridoxal derivatives having a chiral ionophore function"Tetrahedron. 55・41. 12109-12124 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Moromoto, Y.Wada, J.Hinagata, T.Imanishi, T.Kodama, T.Doi: "VXFD in the cytoplamic domain of macrophage scavenger receptors mediates their efficient internalization and cell-surface expression"Biol. Pharm. Bull.. 22. 1022-1026 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Suzuki, T.Doi, T.Imanishi, T.Kodama, T.Tanaka: "Oligonucleotide aggregates bind to the macrophage scavenger receptor"Eur. J. Biochem.. 260. 855-860 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Doi, T.Imanishi, et al.: "Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice"Pharmaceutical Research. 16. 503-508 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, Y.Hari, K.Mori, T.Imanishi: "Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system"Tetrahedron Lett.. 41・2. 215-219 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Obika, Y.Hari, K.Morio, T.Imanishi: "Triplex formation by an oligonucleotide containing conformationally locked C-nucleoside, 5-(2-O,4-C-methylene-β-D-ribofuranosyl)oxazole"Tetrahedron Lett.. 41・2. 221-224 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, Y.Hari, M.Sekiguchi, T.Imanishi: "Synthesis and triplex-forming ability of conformationally locked oligonucleotides containing unnatural nucleobases : Efficient recognition of a C・G interruption"Nucleic Acids Symp. Ser.. 44. 131-132 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Torigoe, S.Obika, T.Imanishi: "Promotion of triplex formation by a fixed N-form sugar puckering : Thermodynamic and kinetic studies"Nucleic Acids Symp. Ser.. 44. 241-242 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, Y.Hari, T.Sugimoto, M.Sekiguchi, T.Imanishi: "Triplex-forming enhancement with high sequence selectivity by single 2'-O,4'-C-methylene bridged nucleic acid(2',4'-BNA)modification"Tetrahedron Lett.. 41・46. 8923-8927 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Miyashita, H.Miyabe, K.Tai, H.Iwaki, T.Imanishi: "Asymmetric α-alkylation of α-amino esters using pyridoxal derivatives having a chiral ansa-structure and a chiral ionophore function : a novel example of double asymmetric induction"Tetrahedron. 56・27. 4691-4700 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Miyashita, M.Minagawa, Y.Ueda, Y.Tada, N.Hoshino, T.Imanishi: "Oxiranes having an acridane structure as a novel chemiluminescent precursor : synthesis and chemiluminescent studies"Tetrahedron. 57・16. 3361-3367 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Miyashita, H.Iwaki, K.Tai, H.Murafuji, N.Sasaki, T.Imanishi: "Regio-and stereoselective α-alkylation of N-terminal amino acid residue of peptides using a pyridoxal model compound with a chiral ansa-structure"Tetrahedron. 57・27. 5773-5780 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, T.Uneda, T.Sugimoto, D.Nanbu, T.Minami, T.Doi, T.Imanishi: "2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA) : Synthesis and triplex-forming properties"Bioorg. Med. Chem.. 9・4. 1001-1011 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, Y.Hari, M.Sekiguchi, T.Imanishi: "A 2',4'-bridged nucleic acid containing 2-pyridone as a nucleobase : Efficient recognition of a C・G interruption by triplex formation with a pyrimidine motif"Angew. Chem., Int. Ed. Engl.. 40・11. 2079-2081 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, K.Miyashita, T.Doi, T.Imanishi et al.: "Symmetrical cationic triglycerides : An efficient synthesis and application to gene transfer"Bioorg. Med. Chem.. 9・2. 245-254 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, M.Onoda, K.Morita, J.Andoh, M.Koizumi, T.Imanishi: "3'-Amino-2',4'-BNA : Novel bridged nucleic acids having an N3'->P5' phosphoramidate linkage"Chem. Commun.. 19. 1992-1993 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Torigoe, S.Obika, T.Imanishi: "Promotion of triplex formation by 2'-O,4'-C-methylene bridged nucleic acid(BNA)modification : Thermodynamic and kinetic studies"Nucleosides, Nucleotides and Nucleic Acids. 20. 1235-1238 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Torigoe, Y.Hari, M.Sekiguchi, S.Obika, T.Imanishi: "2'-O,4'-C-Methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH : Thermodynamic and kinetic studies"J. Biol. Chem.. 276・4. 2354-2360 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, T.Mayumi, T.Imanishi et al.: "Inhibition of ICAM-I gene expression by antisense 2',4'-BNA oligonucleotides"Nucleic Acids Res. Suppl.. 1. 145-146 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, Y.Hari, H.Inohara, T.Imanishi: "2,4'-BNA bearing unnatural nucleobases : Toward the expansion of the target sequence of double-stranded DNA in triplex formation"Nucleic Acids Res. Suppl.. 1. 171-172 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] H.Torigoe, Y.Hari, S.Obika, T.Imanishi: "Triplex formation involving 2',4'-BNA with 2-pyridone base analogue : Efficient and selective recognition of C : G interruption"Nucleic Acids Res. Suppl.. 1. 281-282 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Morita, C.Hasegawa, M.Kaneko, S.Tsutsumi, J.Sone, T.Ishikawa, T.Imanishi, M.koizumi: "2'-O,4'-C-Ethylene-bridged nucleic acids(ENA)with niclease-resistance and high affinity for RNA"Nucleic Acids Res. Suppl.. 1. 241-242 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Morita, C.Hasegawa, M.Kaneko, S.Tsutsumi, J.Sone, T.Ishikawa, T.Imanishi, M.koizumi: "2'-O,4'-C-ethylene-bridged nucleic acids(ENA) : highly nuclease-resistant and thermodynamically stable"Bioorg. Med. Chem. Lett.. 12・1. 73-76 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Hari, S.Obika, N.Sakaki, K.Morio, Y.Ynamagata, T.Imanishi: "Effective synthesis of C-nucleosides with 2',4'-BNA modification"Tetrahedron. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, K.Morio, D.Nanbu, Y.Hari, H.Itoh, T.Imanishi: "Synthesis and conformation of 3',4'-BNA monomers, 3'-O,4'-C-methyleneribonucleosides"Tetrahedron. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] K.Miyashita, M.Park, S.Adachi, S.Seki, S.Obika, T.Imanishi: "A 3,4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit"Bioorg. Med. Chem. Lett.. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S.Obika, T.Imanishi: "BNAs : Novel nucleic acid analogs with a bridged sugar moiety"Chem. Commun.. (印刷中). (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] S. Obika, W. Yu, A. Shimoyama, T. Uneda, T. Minami, K. Miyashita, T. Doi and T. Imanishi: "Properties of cationic liposomes composed of cationic lipid YKS-220 having an ester linkage: adequate stability, high transfection efficiency, and low cytotoxicity"Biol. Pharm. Bull.. 22-2. 187-190 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] W. Yu, A. Shimoyama, T. Uneda, S. Obika, K. Miyashita, T. Doi and T. Imanishi: "Gene transfer mediated by YKS-220 cationic particles: convenient and efficient gene delivery reagent"J. Biochem.. 125-6. 1034-1038 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, K. Morio, Y. Hari and T. Imanishi: "Preparation and properties of 2',5'-linked oligonucleotide analogues containing 3'-O,4'-C-methyleneribonucleosides"Bioorg. Med. Chem. Lett.. 9-4. 515-518 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, J. Andoh, T. Sugimoto, K. Miyashita and T. Imanishi: "Synthesis of a conformationally locked AZT analogue 3'-azido-3'-deoxy-2'-O,4'-C-methylene-5-methyluridine"Tetrahedron Lett.. 40-35. 6465-6468 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Okiba, K. Morio, Y. Hari and T. Imanishi: "Facile synthesis and conformation of 3'-O,4'-C-methyleneribonucleosides"Chem. Commun.. 23. 2423-2424 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Miyashita, H. Miyabe, K. Tai, C. Kurozumi, H. Iwaki and T. Imanishi: "Chiral environment specifically induced by metal ion: asymmetric α-alkylation of α-amino esters, using pyridoxal derivatives having a chiral ionosphere function"Tetrahedron. 55-41. 12109-12124 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Moromoto, Y. Wada, J. Hinagata, T. Imanishi, T. Kodama and T. Doi: "VXFD in the cytoplamic domain of macrophage scavenger receptors mediates their efficient internalization and cell-surface expression"Biol. Pharm. Bull.. 22. 1022-1026 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Suzuki, T. Doi, T. Imanishi, T. Kodama and T. Tanaka: "Oligonucleotide aggregates bind to the macrophage scavenger receptor"Eur. J. Biochem.. 260. 855-860 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Takakura, T, Takagi M. Hashiguchi, M. Nishikawa, F. Yamashita, T. Doi, T. Imanishi, H. Suzuki, T. Kodama and M. Hashida: "Characterization of plasmid DNA binding and uptake by peritoneal macrophages from class A scavenger receptor knockout mice"Pharmaceutical Research. 16. 503-508 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, K. Morio and T. Imanishi: "Synthesis of conformationally locked C-nucleosides having a 2,5-dioxabicyclo[2.2.1]heptane ring system"Tetrahedron Lett.. 41-2. 215-219 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, K. Morio and T. Imanishi: "Triplex formation by an oligonucleotide containing conformationally locked C-nucleoside, 5-(2-O,4-C-methylene-β-D-ribofuranosyl)oxazole"Tetrahedron Lett.. 41-2. 221-224 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, M. Sekiguchi and T. Imanishi: "Synthesis and triplex-forming ability of conformationally, locked oligonucleotides containing unnatural nucleobases: Efficient recognition of a C-G interruption"Nucleic Acids Symp. Ser.. 44. 131-132 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Torigoe, S. Obika and T. Imanishi: "Promotion of triplex formation by a fixed N-form sugar puckering: Thermodynamic and kinetic studies"Nucleic Acids Symp. Ser.. 44. 241-242 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, T. Sugimoto, M. Sekiguchi and T. Imanishi: "Triplex-forming enhancement with high sequence selectivity by single 2'-O,4'-C-methylene bridged nucleic acid (2',4'-BNA) modification"Tetrahedron Lett.. 41-46. 8923-8927 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Miyashita, H. Miyabe, K. Tai, H. Iwaki and T. Imanishi: "Asymmetric a-alkylation of α-amino esters using pyridoxal derivatives having a chiral ansa-structure and a chiral ionophore function: a novel example of double asymmetric induction"Tetrahedron. 56-27. 4691-4700 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Miyashita, M. Minagawa Y. Ueda, Y. Tada, N. Hoshino and T. Imanishi: "Oxiranes having an acridane structure as a novel chemiluminescent precursor: synthesis and chemiluminescent studies"Tetrahedron. 57-16. 3361-3367 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Miyashita, H. Iwaki, K. Tai, H. Murafuji, N. Sasaki and T. Imanishi: "Regio- and stereoselective α-alkylation of N-terminal amino acid residue of peptides using a pyridoxal model compound with a chiral ansa-structure"Tetrahedron. 57-27. 5773-5780 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, T. Uneda, T. Sugimoto, D. Nanbu, T. Minami, T. Doi and T. Imanishi: "2'-O,4'-C-Methylene bridged nucleic acid (2',4'-BNA): Synthesis and triplex-forming properties"Bioorg. Med. Chem.. 9-4. 1001-1011 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, M. Sekiguchi and T. Imanishi: "A 2',4'-bridged nucleic acid containing 2-pyridone as a nucleobase: Efficient recognition of a C-G interruption by triplex formation with a pyrimidine motif"Angew. Chem., Int. Ed. Engl.. 40-11. 2079-2081 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, W. Yu, A. Shimoyama, T. Uneda, K. Miyashita, T. Doi and T. Imanishi: "Symmetrical cationic triglycerides: An efficient synthesis and application to gene transfer"Bioorg. Med. Chem.. 9-2. 245-254 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, M. Onoda, K. Morita, J. Andoh, M. Koizumi and T. Imanishi: "3'-Amino-2',4'-BNA: Novel bridged nucleic acids having an N3'->P5' phosphoramidate linkage"Chem. Commun.. 19. 1992-1993 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Torigoe, S. Obika and T. Imanishi: "Promotion of triplex formation by 2'-O,4'-C-methylene bridged nucleic acid (BNA) modification: Thermodynamic and kinetic studies"Nucleosides, Nucleotides and Nucleic Acids. 20-(4-7). 1235-1238 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Torigoe, Y. Hari, M. Sekiguchi, S. Obika and T. Imanishi: "2'-O,4'-C-Methylene bridged nucleic acid modification promotes pyrimidine motif triplex DNA formation at physiological pH: Thermodynamic and kinetic studies"J. Biol. Chem.. 276-4. 2354-2360 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, R. Henanayi T. Masuda, T. Sugimoto, S. Nakagawa, T. Mayumi and T. Imanishi: "Inhibition of ICAM-I gene expression by antisense 2',4'-BNA oligonucleotides"Nucleic Acids Res. Suppl.. 1. 145-146 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, Y. Hari, H. Inohara and T. Imanishi: "2,4'-BNA bearing unnatural nucleobases: Toward the expansion of the target sequence of double-stranded DNA in triplex formation"Nucleic Acids Res. Suppl.. 1. 171-172 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] H. Torigoe, Y. Hari, S. Obika and T. Imanishi: "Triplex formation involving 2',4'-BNA with 2-pyridone base analogue: Efficient arid selective recognition of C:G interruption"Nucleic Acids Res. Suppl.. 1. 281-282 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Morita, C. Hasegawa, M. Kaneko, S. Tsutsumi, J. Sone, T. Ishikawa, T. Imanishi and M. Koizumi: "2'-O,4'-C-Ethyiene-bridged nucleic acids (ENA) with nuclease-resistance and high affinity for RNA"Nucleic Acids Res. Suppl.. 1. 241-242 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Morita, C. Hasegawa, M. Kaneko, S. Tsutsumi, J. Sone, T. Ishikawa, T. Imanishi and M. Koizumi: "2'-O,4'-C-ethylene-bridged nucleic acids (ENA): highly nuclease-resistant and thermodynamically stable oligonucleotides for antisense drug"Bioorg. Med. Chem. Lett.. 12-1. 73-76 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Hari, S. Obika, M. Sakaki, K. Morio, Y. Ynamagata and T. Imanishi: "Effective synthesis of C-nucleosides with 2',4'-BNA modification"Tetrahedron. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika, K. Morio, D. Nanbu, Y. Hari, H. Itoh and T. Imanishi: "Synthesis and conformation of 3',4'-BNA monomers, 3'-O,4'-C-methyleneribonucleosides"Tetrahedron. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] K. Miyashita, M. Park, S. Adachi, S. Seki, S. Obika and T. Imanishi: "A 3,4-Epoxypiperidine structure as a novel and simple DNA-cleavage unit"Bioorg. Med. Chem. Lett.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] S. Obika and T. Imanishi: "BNAs: Novel nucleic acid analogs with a bridged sugar moiety"Chem. Commun.. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 2003-09-17  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi