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2001 Fiscal Year Final Research Report Summary

Mechanism of GAGA factor-dependent chromatin remodeling

Research Project

Project/Area Number 11480204
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Molecular biology
Research InstitutionNational Institute of Genetics

Principal Investigator

HIROSE Susumu  National Institute of Genetics, Department of Development Genetics, Professor, 個体遺伝研究系, 教授 (90022730)

Co-Investigator(Kenkyū-buntansha) UEDA Hitoshi  National Institute of Genetics, Department of Development Genetics, Associate Professor, 個体遺伝研究系, 助教授 (60201349)
Project Period (FY) 1999 – 2001
KeywordsDrosophila / GAGA factor / chromatic / nucleosome / gene expression
Research Abstract

Drosophila GAGA factor directs chromatin remodeling to its binding sites. To elucidate the mechanism underlying the site-specific chromatin remodeling, we searched for GAGA factor-associated proteins. We identified two GAGA factor-associated proteins p93 and p130, and analyzed them. The results obtained showed that p93 and p130 form a heterodimer, bind to nucleosome, and facilitate chromatin remodeling. We also found that GAGA factor, p93 and p130 colocalyze to active chromatin on polytene chromosomes. Moreover, genetic interaction between Trithorax-like and p130 implicates GAGA factor-p93-p130 complex in epigenetic gene expression.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] M.Kobayashi: "Functional dissection of DNA supercoiling factor : EF-hand domains and C-terminal HDEF motif are essential for its activity"Genes Cells. 4. 33-40 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Kabe: "The role of human MBF1 as a transcriptional coactivator"J.Biol.Chem.. 274. 34196-34202 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Q.-X.Liu: "MBF2 is a tissue-and stage-specific coactivator that is regulated at the step of nuclear transport in the silkworm Bombyx mori"Dev.Biol.. 225. 437-446 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Asahina: "The conserved nuclear receptor FTZ-F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans"Genes Cells. 5. 711-723 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Yamada: "Temporally restricted expression of FTZ-F1 transcription factor-Significance for embryogenesis, molting and metamorphosis in Drosophila melanogaster"Development. 127. 5083-5092 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Q.-X.Liu: "Drosophila MBF1 in a coactivator for Tracheae defective and contributes to the formation of tracheal and nervous systems"Development. (in press).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M. Kobayashi: "Functional dissection of DNA supercoiling factor : EF-hand domains and C-terminal HDEF motif are essential for its activity"Genes Cells. 4. 33-40 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Kabe: "The role of human MBF1 as a transcriptional coactivator"J. Biol Chem.. 274. 34196-34202 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Q.-X. Liu: "MBF2 is a tissue- and stage-specific coactivator that is regulated at the step of nuclear transport in the silkworm Bombyx mori"Dev. Biol.. 225. 437-446 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Asahina: "The conserved nuclear receptor FTZ-F1 is required for embryogenesis, moulting and reproduction in Caenorhabditis elegans"Genes Cells. 5. 711-723 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M. Yamada: "Temporally restricted expression of FTZ-F1 transcription factor-Significance for embroygenesis, molting and metamorphosis in Drosophila melanogaster"Development. 127. 5083-5092 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Q.-X. Liu: "Drosophila MBF1 is a coactivator for Trachease defective and contributes to the formation of tracheal and nervous systems"Development. (in press).

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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