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2001 Fiscal Year Final Research Report Summary

Genetic analysis of diabetes in SMXA recombinant inbred strain of mice.

Research Project

Project/Area Number 11556024
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section展開研究
Research Field 食品科学・栄養科学
Research InstitutionNAGOYA UNIVERSITY

Principal Investigator

HORIO Fumihiko  Graduate School of Bioagricultural Sciences, Nagoya University, Associate Professor, 大学院・生命農学研究科, 助教授 (20165591)

Co-Investigator(Kenkyū-buntansha) IKEGAMI Hiroshi  Osaka University Medical School, Assistant professor, 医学部, 助手 (20221062)
NISHIMURA Masahiko  Nagoya University Medical School, Professor, 医学部, 教授 (20073661)
Project Period (FY) 1999 – 2001
KeywordsDiabetes / Glucose tolerance / QTL analysis / Disease model / Diabetogenic gene
Research Abstract

Type 2 diabetes in humans is not a single gene disorder, but rather it is brought about by the interaction of multiple genes and environmental factors. Recombinant inbred (RI) strains are a powerful tool for analyzing not only single genetic traits, but also multifactorial genetic traits. By using the SMXA RI mice, we genetically dissected diabetes-related traits (BMI, non-fasting blood glucose concentration, and blood glucose concentration during IPGTT). In this study, all mice were fed the high-carbohydrate diet, because feeding this diet minimizes the variation of glucose tolerance in each strain. The parental strains, SM/J and A/J, were non-diabetic, and the differences of the mean values on diabetes-related traits were small. On the other hand, "notable differences" in the mean values of some diabetes-related traits were observed in 19 SMXA RI strains. Several SMXA RI strains showed distinct impaired glucose tolerance and hyperglycemia. QTL analysis revealed six diabetes-related loci on four chromosomes which exceeding the threshold for suggestive level. Especially, a locus on Chr 10 concerning non-fasting blood glucose concentration, was over significant threshold. The A/J-derived genome at two loci on Chr 2 and 18, oppositely the SM/J-derived genome at one locus on Chr 10, contributed to the impairment of glucose tolerance and/or the increase of blood glucose concentration. The present study indicate that the I combinations between silent SM/J and A/J allele can appear to elicit hyperglycemia and impaired glucose tolerance. Genetic dissection of this kind of diabetogenesis may contribute to understand the complex mode of inheritance in human type 2 diabetes.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Ohno, T., Horio, F.(第二著者) その他: "Fatty liver and hyperlipidemia in IDDM (insulin-dependent diabetes mellitus) of streptozotocin-treated shrews"Life Sci.. 66. 125-131 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anunciado, R.V.P., Horio, F.(第四著者) その他: "Developping a new Model for non-insulin dependent diabetes mellitus (NIDDM) by using the Philippine wild mouse, Mus museums castaneus"Exp. Anim.. 49. 1-8 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anunciado, R.V.P., Horio, F.(第二著者) その他: "Characterization of Hyperinsulinemic Recombinant inbred (RI) strains (SMXA-5 and SMXA-9) derived from normoinsulinemic SM/J and A/J mice"Exp. Anim.. 49. 83-90 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anunciado, R.V.P., Horio, F.(第六著者) その他: "Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis"Exp. Anim.. 49. 217-224 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Anunciado, R.V.P., Horio, F.(第六著者) その他: "Quantitative trait loci for body weight in the intercross between SM/J and A/J mice"Exp. Anim.. 50. 319-324 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohno, T., Horio, F.(第二著者) その他: "Blood and liver concentrations in EDS Shrews exhibiting spontaneous non-insulin dependent diabetes mellitus (NIDDM)"Exp. Anim.. 50. 427-429 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ohno,T. , Horio,-F. , Tanaka,S. , Terada.M., Namikawa,T. and kitoh.J.: "Fatty liver and hyperlipidemia in IDDM (insulin-dependent diabetes mellitus) of streptozotocin-treated shrews"Life. Sci.. 66. 125-131 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anunciado,R.V. R , Imamura,T. , Ohno,T. ,Horio,F. and Namikawa,T.: "Developping a new Model for non-insulin dependent diabetes mellitus (NIDDM) by using the Philippine wild mouse, Mus musculus castaneus"Exp. Anim.. 49. 1-8 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anunciado, R.V. P. , Horio.K , Ohno,T. , Tanaka.S., Nishimura,M. and Namikawa,T.: "Characterization of Hyperinsuli nemic Recombinant inbred (RI) strains (SMXA-5 and SMXA-9) derived from normoinsulinemic SM/J and A/J mice"Exp. Anim.. 49. 83-90 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anunciado,R.V. P. , Ohno,T. , Mori.M. Ishikawa,A.,Tanaka,S. , Horio,R , Nishimura,M. and Namikawa,T.: "Distribution of body weight, blood insulin and lipid levels in the SMXA recombinant inbred strains and the QTL analysis"Exp. Anim.. 49. 217-224 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Anunciado, R.V.P. , Nishimura, M, Mori,M, Ishikawa,A-, Tanaka,S., Horio.E , Ohno,T. and Namikawa,T.: "Quantitative trait loci for body weight in the intercross between SM/J and A/J mice"Exp.Anim.. 50. 309-324 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ohno,T. , Horio,R , Kitoh,J., Tanaka,S. , Nishimura,M and Namikawa,T.: "Blood and liver concentrations in EDS shrews exhibiting spontaneous non-insulin dependent diabetes mellitus (NIDDM)"Exp.Anim.. 50. 427-429 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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