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2000 Fiscal Year Final Research Report Summary

"Development of chiral-selective amine acid sensors"

Research Project

Project/Area Number 11640609
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field 分離・精製・検出法
Research InstitutionYamaguchi University

Principal Investigator

NAGAOKA Tsutomu  Yamaguchi University, Faculty of Engineering, Professor, 工学部, 教授 (00172510)

Co-Investigator(Kenkyū-buntansha) NAKAYAMA Masaharu  Yamaguchi University, Faculty of Engineering, Research Associate, 工学部, 助手 (70274181)
OGURA Kotaro  Yamaguchi University, Faculty of Engineering, Professor, 工学部, 教授 (40035077)
Project Period (FY) 1999 – 2000
KeywordsConducting Potymer / Overoxidation / Molecular Recognition / Enantiomer / Amino Acid / Sensor / Templated Potymer / Polypyrrole
Research Abstract

Overoxidized polypyrrole films templated with L-glutamate have been utilized for enantiomeric separation of L-and D-glutamic acid. Various important fabrication factors controlling the performance of the overoxidized polypyrrole films have been investigated using fluorescence spectrometry in conjugation with the electrochemical quartz crystal microbalance technique. The measured fluorescence intensity was related to the concentration of glutamate taken up into the films. It was found that L-glutamate was inserted about 30 times as much into the film as D-glutamate. Several key parameters such as applied potential, and pH of amino acid solution were varied so as to achieve the optimum sensor response. The sensor templated with L-glutamic acid also exhibited excellent selectivity over several other L-and D-amino acids. Higher enantioselectivity of overoxidized polypyrrole film than that for previously reported imprinted polymers can be attributed to the potential-induced uptake/release of targeted molecules.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Z.Chen,T.Nagaoka: "Ligand exchange stripping technique for enantio-concentration and separation of amino acies"Electroanalysis. 11. 1169-1171 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] T.Nagaoka,K.Ogura: "Electroactivity of polypyrrole colloids enhanced by quinone mediation"J.Electrochem.Soc.. 146. 3378-3382 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] B.Deore,T.Nagaoka: "Overoxidized polypyrrole with dopant complementary cavities as a new molecularlyimprinted polymer matrix"Anal.Sci.. 15. 827-828 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 陳智棟,長岡勉: "モレキュラーインプリント法により作製した自己組織化膜電極を用いるビタミンK1の認識"分析化学. 49. 543-545 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] B.Deore,Z.Chen and T.Nagaoka: "Potential-induced enantioselective uptake of amino acid into molecularly-imprinted overoxidized polypyrrole"Anal.Chem.. 72. 3989-3994 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Z.Chen,Y.Takei,B.A.Deore,and T.Nagaoka: "Enantioselective uptake of amino acid with overoxidized polypyrrole colloid templated with L-lactate"Analyst. 125. 2249-2259 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Z.Chen., N.Sakumoto, M.Koyama, H.Nakao, and T.Nagaoka: "Ligand exchange stripping technique for enantio-concentration and separation of amino acids using a carbon column electrode modified with N-(2-Naphthalenesulfonyl)-L-phenylalanine as a cliral selector"Electroanalysis. 11. 1169-1171 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] T.Nagaoka, S.M.Ahmed, and K.Ogura: "Electroactivity of polypyrrole colloids enhanced by quinone mediation"J.Electrochem.Soc.. 146. 3378-3382 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] B.Deore, Z.Chen and T.Nagaoka: "Overoxidized polypyrrole with dopant complementary cavities as a new molecularly imprinted polymer matrix"Anal.Sci.. 15. 827-828 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Z.Chen, and T.Nagaoka: "Recognition of vitamin K1 with a molecularly imprinted self-assembled monolayer film"BUNSEKI KAGAKU. 49. 543-545 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] B.Deore, Z.Chen and T.Nagaoka: "Potential-induced enantioselective uptake of amino acid into molecularly-imprinted overoxidized polypyrrole"Anal.Chem.. 72. 3989-3994 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Z.Chen, Y.Takei, B.A.Deore, and T.Nagaoka: "Enantioselective uptake of amino acid with overoxidized polypyrrole colloid templated with L-lactate"Analyst. 125. 2249-2259 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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