2001 Fiscal Year Final Research Report Summary
Cytokine found in insects for the forsttime ; studies on its activation mechanism and multi function
| Project/Area Number |
11640674
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
動物生理・代謝
|
|---|
| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
HAYAKAWA Yoichi Hokkaido Univ., Inst Low Tem. Sci., Asso. Prof., 低温科学研究所, 助教授 (50164926)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
SHIMADA Kimio Hokkaido Univ., Inst Low Tem. Sci., Assist. Prof., 低温科学研究所, 助手 (30001663)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Keywords | Insects / cytokine / processing enzyme / growth-blocking peptide (GBP) / stress / immunity / blood coagulation factor Xa |
|---|
| Research Abstract |
Growth-blocking peptide (GBP) is a cytokine found in insects for the first time. GBP is synthesized as a precursor protein mainly in fat body and the proGBP processing enzyme activity is present in fat body of the armyworm larvae. We purified the proGBP processing enzyme, and found that it has similar substrate specificity with Factor Xa in mammals.
|
Research Products
(27 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Publications] T. Aizawa., Y. Hayakawa, A. Ohnishi, N. Fujitani, K. D. Clark., M. R. Strand., K. Miura, N., Koganwzawa, Y. Kumaki, M. Demura., K. Nitta, K. Kawano: "Structure and activity of the insect cytokine growth-blocking pe ptide"J. Biol. Chem.. 276. 31813-31818 (2001)
Description
「研究成果報告書概要(欧文)」より
-
-
-
