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2001 Fiscal Year Final Research Report Summary

Study on the mechanical properties of tibial cartilage and subchondral bone

Research Project

Project/Area Number 11650110
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Materials/Mechanics of materials
Research InstitutionNIIGATA UNIVERSITY (2000-2001)
Niigata College of Technology (1999)

Principal Investigator

SAKAMOTO Makoto  Faculty of Medicine, Niigata University, Professor, 医学部, 教授 (80215657)

Co-Investigator(Kenkyū-buntansha) ENDO Naoto  Faculty of Medicine, Niigata University, Professor, 大学院・医歯学総合研究科, 教授 (10251810)
Project Period (FY) 1999 – 2001
KeywordsBiomechanics / Strength of materials / Cartilage / Cortical bone / Indentation test / Ultrasonic / Elastic modulus / Microhardness
Research Abstract

The subchondral cortex lies immediately below the thin layer of calcified cartilage. It is a layer dense, stiff, cortical bone. In the mature human, it forms a closed cap supporting the cartilage on one side and supported by the cancellous bone on the other. Unanswered questions regarding the etiology of primary osteoarthritis, as well as the recent interest in the use of finite element analysis in the study of knee joint, suggest a need for detailed data on the mechanical properties of subchondral bone as a specific structural entity. However, only limited information is presently available on mechanical property of subchondral bone because of the lack of appropriate local elastic property measuring method.
In this study we measured the elastic modulus of human proximal tibial subchondral bone and articular cartilage in the osteoarthritis of knee joint using the scanning acoustic microscope (SAM), peripheral quantitative computed tomography (pQCT) and the indentation method. Proximal tibial plates were taken from human tibiae of osteoarthrosis joints. Disc-shaped specimens were machined from standardized locations on these plates with a core drill. The axes of the specimens were parallel to the long axis of tibia. The distribution of cartilage thickness was measured by needle method. Following is an example results obtain through this experiment. There is a serious damage on the cartilage from the center to posterior of medial condyle and the subchondral boneis exposed. In the medial condyle, the density and the elastic modulus of the subchondral bone is higher at posterior area than anterior.

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 高野公彦: "皮質骨の微小硬さと力学的引張り特性との関係"日本臨床バイオメカニクス学会誌. 21. 401-406 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高橋光: "pQCTを利用したwhole boneの力学的特性評価"日本臨床バイオメカニクス学会誌. 21. 409-414 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 山崎安克: "脛骨膝関節近傍組織の力学的特性評価"日本機械学会12回バイオエンジニアリング講演会・講演論文集. 99-37. 109-110 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "皮質骨の微小硬さと引張り特性との関係"日本機械学会12回バイオエンジニアリング講演会・講演論文集. 99-37. 75-76 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "ウシ皮質骨の微小硬さと引張り特性との関係"日本機械学会2000年度年次大会・講演論文集. 00-1. 415-416 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "The relationship between microhardness and bending strength of bovine cortical bone"12th Conference of tbe European Society of Biomechanics. 12. 33 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "硬組織の微小硬さによる局所弾性率の評価"日本臨床バイオメカニクス学会誌. 22. 51-57 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "Prediction of elastic modulus of cortieal bone using microhardiless testing"Theoretical and Applied Mechanics. 50. 97-101 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 永井克洋: "微小試験片による骨の力学的特性評価"日本機械学会第13回バイオエンジニアリング講演会・講演論文集. 00-35. 106-107 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂本信: "Prediction of local elestic modulus of bovine cortical bone usicg microhardness testing"XVIIIth Congress of the International Society of Biomecbanics. 18. 213-214 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 坂井淳: "Evaluation of microhardness and bending strength of cortical bone"Proceedings of APCFS & ATEM '01. 01-203. 884-887 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kimihiko Takano: "The relationship between microhardness and mechanical tensile property of cortical bone"Journal of Japanese Society for Clinical Biomechanics. vol. 21. 401-406 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Takahashi: "An evaluation of mechanical properties of whole bone using PQCT"Journal of Japanese Society for Clinical Biomechanics. vol. 21. 409-414 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yasukatsu Yamazaki: "The evaluation of mechanical properties of proximal tibial tissue in the knee joint"The 12th Bioengineering Conference, 1999 Annual Meeting of BE D/JSME. vol. 99-37. 109-111 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "The relationship between microhardness and tensile property of cortical bone"The 12th Bioengineering Conference, 1999 Annual Meeting of BE D/JSME. vol. 99-37. 75-76 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "The relationship between microhardness and tensile property of bovine cortical bone"2000 Annual Meeting of JSME. vol. 00-1. 415-416 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "The relationship between microhardness and bending strength of bovine cortical bone"12th Conference of the European Society of Biomechanics. vol. 12. 33 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "Estimation of local elastic modulus of hard tissues using Microhardness"Journal of Japanese Society for Clinical Biomechanics. vol. 22. 51-57 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "Prediction of elastic modulus of cortical bone using microhardness testing"Theoretical and Applied Mechanics. vol. 50. 97-101 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsuhiro Nagai: "Mechanical evaluation of bone property using minute specimens"The 13th Bioengineering Conference, 2000 Annual Meeting of BE D/JSME. vol. 00-37. 106-107 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Makoto Sakamoto: "Prediction of local elastic modulus of bovine cortical bone using microhardness testing"XVIIIth Congress of the International Society of Biomechanics. vol. 18. 213-214 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Jun Sakai: "Evaluation of microhardness and bending strength of cortical bone"Proceedings of APCFS & ATEM '01. vol. 01-203. 884-887 (2001)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2003-09-17  

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