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2000 Fiscal Year Final Research Report Summary

Effect of fatal hypoxia on ventilatory responses to hypoxia

Research Project

Project/Area Number 11670058
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Environmental physiology (including Physical medicine and Nutritional physiology)
Research InstitutionChiba university

Principal Investigator

HAYASHI Fumiaki  Chiba University, School of Med., Associate Professor, 医学部, 助教授 (80173029)

Co-Investigator(Kenkyū-buntansha) MASUYAMA Shigeru  Chiba University, School of Med., Assistant Professor, 医学部, 助手 (00219354)
Project Period (FY) 1999 – 2000
Keywordsfetal hypoxia / high altitude acclimatization / high land native / hypoxic ventilatory response / developmental plasticity / neuronal circuit / rat
Research Abstract

The underlying mechanisms for the attenuated hypoxic ventilatory response observed in a highland native are still controversial. In addition two proposed mechanisms (e.g., genetic or acquired), the developmental plasticity for the neuronal circuits for the respiratory control has recently been noticed. We, therefore, hypothesized that the fetal hypoxia is the determinant factor on the attenuated hypoxic ventilatory response seen in highland natives.
The rat was exposed to 11% of hypoxia (corresponding to 4000-4500 meters altitude) for 14 days before birth and 4 weeks after birth. Thereafter, the animal was returned to normoxic chamber (21% O2). The ventilatory response to hypoxia (difference in the ventilation between air and 10% O2) was determined at 4,5,6,8 and 12 weeks after birth. The ventilatory parameters (VT, f and VE) were measured by a whole body plethysmograph.
The ventilatory response to hypoxia was significantly attenuated at 4 and 5 weeks after birth, but was returned to the control value after this period. The attenuated ventilatory response to hypoxia seen in rats exposed before and after birth, was considered to be due to a acclimatization to hypoxia, but not due to developmental plasticity of neuronal circuit controlling hypoxia ventilatory responses.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Shiba K et al.: "Multifunctional laryngeal motoneurons in the cat : an intracellular study."J Neurosci. 19. 2717-2727 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Taki J, et al.: "Increased cardiovascular and metabolic tolerance to acute hypoxia in the rat with increased hemoglobin-O2 affinity induced by Na-cyanate treatment."Jpn J Physiol. 49. 256-271 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kumano K et al.: "Interluekin-18 enhances antigen-induced eosinophil recruitment into the mouse rirways."Am J Respir Crit Care Med. 160. 873-878 (1999)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hayashi F & Fukuda Y: "Neuronal mechanisms mediating the integration of ventilatory responses to hypoxia."Jap J Physiol. 50. 15-24 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sudo T et al.: "Responses of tracheobronchial receptors to inhaled furosemide in anesthetized rats"Am J Respir Crit Care Med. 162. 971-975 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kato T et al.: "Inhibitory mechanisms in hypoxic respiratory depression studied in an in vitro preparation."Neurosci Res. 38. 281-288 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] McCrimmon DR et al.: "Pattern formation and rhythm generation in the ventral respiratory group."Clin Exp Pharmacol Physiol. 27. 126-131 (2000)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shiba K: "Multifunctional laryngeal motoneurons in the cat : an intracellular study"J Neurosci. 19. 2717-2727 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Taki J: "Increased cardiovascular and metabolic tolerance to acute hypoxia in the rat with increased hemoglobin-O2 affinity induced by Na-cyanate treatment."Jpn J Physiol. 49. 256-271 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kumano K, Kurimoto M, Okamura H, Saito Y & Iwamoto I: "Interleukin-18 enhances antigen-induced eosinophil recruitment into the mouse rirways."Am J Respir Crit Care Med. 160. 873-878 (1999)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] McCrimmon DR: "Zuperku EJ.Pattern formation and rhythm generation in the ventral respiratory group."Clin Exp Pharmacol Physiol. 27. 126-131 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hayashi F: "Neuronal mechanisms mediating the integration of ventilatory responses to hypoxia."Jap J Physiol. 50. 15-24 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kato T: "Fukuda Y.Inhibitory mechanisms in hypoxic respiratory depression studied in an in vitro preparation."Neuroscie Res. 38. 281-288 (2000)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sudo T: "Responses of tracheobronchial receptors to inhaled furosemide in anesthetized rats."Am J Respir Crit Care Med. 162. 971-975 (2000)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2002-03-26  

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