2000 Fiscal Year Final Research Report Summary
Molecular pathological research of the genesis and development of serrated adenoma of the colorectum
| Project/Area Number |
11670170
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Human pathology
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| Research Institution | NIIGATA UNIVERSITY |
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Principal Investigator |
AJIOKA Yoichi School of Medicine, NIIGATA UNIVERSITY, Associated Professor, 医学部, 助教授 (80222610)
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| Project Period (FY) |
1999 – 2000
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| Keywords | colorectal adenoma / serrated adenoma / K-ras / APC / p53 |
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| Research Abstract |
Genetica alterations were examined for 63 serrated adenomas(SA)and 10 carcinoma in serrated adenoma(CA/SA).
1. K-ras codon 12 mutations were found only in 6.3%(4/63)of SA, and two of them were mixed polyp consisted of admixture of SA and ordinary tubular adenoma. No mutation was found in CA/SA.
2. Alterations of APC gene were found in one SA polyp, alone.
3. p53 protein overexpression was examined using anti-human p53 protein monoclonal antibody(PAb1801). Overexpression was noticed in 3.2%(2/63)of SA and 80%(8/10)of carcinomatous component of CA/SA.
4. Alteration of APC and K-ras genes may not play a role in genesis and development of SA.however, p53 alteration would be related in carcinogenesis of SA.
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