2001 Fiscal Year Final Research Report Summary
Studies on opportunistic oncogenesis in immunodeficient mouse by murine retroviruses.
| Project/Area Number |
11670291
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | KYOTO UNIVERSITY |
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Principal Investigator |
ISHIMOTO Akinori Institute for virus search department of viral oncology, Kyoto University Professor, ウイルス研究所, 教授 (50073127)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAI Hiroyuki Institute for virus search department of viral oncology, Kyoto University, associate Professor, ウイルス研究所, 助教授 (80281731)
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| Project Period (FY) |
1999 – 2001
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| Keywords | opportunistic cancer / Retrovirus / Murine Leukemia Virus / Murine AIDS virus |
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| Research Abstract |
Fv-4 is a mouse gene that dominantly confers resistance to infection with Friend murine leukemia virus(F-MuLV). To confirm the immunological effect on the resistance in adolescent mice with the Fv-4^<r/r> and Fv-4r^<r/-> genotypes, we examined the effect of an immunosuppressant drug, FK506, on the resistance. The mice with the Fv-4^<r/r> genotype treated with FK506 still showed resistance, but the mice with the Fv-4^<r/-> genotype became highly sensitive to F-MuLV infection.
Recently we found that N-tropic ecotropic MuLV isolated from SL-mice induced myeloid leukemia in CBA nude mice(Ntype strain).
We infected NB-tropic anemia-inducing Friend MuLV to newborn and young-adult Syrian hamsters. About half of the hamsters neonatally infected manifested interrupted growth, presenting runting syndrome-like desease or wasting desease, and all the runt hamsters died within 4 weeks of the inoculation, while the remaining hamsters showed no obvious sings of disease such as interrupted growth, leukemia or neurological disease.
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Research Products
(6 results)
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[Publications] Ta Yar La Min, K. Higo, Y. Kubo, Y. Wang, L.-M. Lu, F. Zhang, Y. Iwatani, L. Wang, T. Ono, M. Maeda, H. Sakai, and A. Ishimoto: "Induction of B-cell Iymphoma in BALB/c nude mice with an ecotropic, B-tropic helper virus present in the MAIDS virus stock"J. Virology. 73. 1640-1644 (1999)
Description
「研究成果報告書概要(欧文)」より
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[Publications] F. Zhang, Ta Yar La Min, Y. Iwatani, K. Higo, Y. Suzuki, M. Tanaka, T. Nakahara, T. Ono, H. Sakai, K. Kuribayashi, A. Ishimoto: "Resistance to Friend Murine Leukemia Virus Infection Conferred by the Fv-4 Gene Is Recessive but Appears Dominant from the Effect of the Immune System"J. of Virology. 74, No.13. 6193-6197 (2000)
Description
「研究成果報告書概要(欧文)」より
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