2000 Fiscal Year Final Research Report Summary
Analysis of HLA disease association among the patients patients with silicosis-To make a check list to prevent work-related diseases.
| Project/Area Number |
11670355
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kawasaki Medical School |
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Principal Investigator |
UEKI Ayako Kawasaki Medical School Dept. of Hygiene Professor, 医学部, 教授 (10069031)
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| Co-Investigator(Kenkyū-buntansha) |
TOMOKUNI Akiko Kawasaki Medical School Dept. of Hygiene Assistant, 医学部, 助手 (30278957)
HYODOH Fuminori Kawasaki Medical School Dept. of Hygiene Instructor, 医学部, 講師 (80069070)
OTSUKI Takemi Kawasaki Medical School Dept. of Hygiene Associate Professor, 医学部, 助教授 (40160551)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Work-related diseases / autoimmune response / silicosis / silica silicate / HLA-typing / preventive medicine |
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| Research Abstract |
Several environmental factors have been reported to induce autoimmune diseases. We have analysed autoimmune responses detected in the patients with silicosis.
In this study, we detected several kinds of autoantibodies in the sera from silicosis patients, e.g. anti-topoisomerase I or anti-β-tubulin autoantibodies. We reported that a distinct amino acid sequence in the HLA-DQ β 1 domain associated with anti-topoisomerase I autoantibodies. In addition, several other observations help us to make a check list to prevent work-related diseases among the workers exposed to silica or silicate dust.
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