2001 Fiscal Year Final Research Report Summary
Children with Survival Analysis of Severe Motor and Intellectual Disabilities Syndrome
| Project/Area Number |
11670390
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Public health/Health science
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| Research Institution | Nihon University |
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Principal Investigator |
YOKOYAMA Eise School of Medicine, Department of Public Health, NIHON UNIVERSITY, Associate Professor, 医学部, 助教授 (90120584)
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| Co-Investigator(Kenkyū-buntansha) |
NAKAMURA Hiroshi Japan Women's University, Department of Child Studies, Professor, 家政学部, 教授 (00277675)
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| Project Period (FY) |
1999 – 2001
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| Keywords | SMIDS / Survival Analysis / Prognosis |
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| Research Abstract |
Children with Severe Motor and Intellectual Disabilities Syndrome(SMIDS) cared for in national hospitals were studied concerning their survival rate and prognosis. The 1988 nationalwide survey data on personal check lists for patients in national hospital. They had remained under observation for 8 years until 1955, when 6,005 were found to have survived and 515 died. Results were as follows ;
1. Mortality rate was highest 14.9% for patients in Oshima's Category I.
2. Survival analysis )by Kaplan-Meire methods) : Survival rate by age stood at 80.1 for children aged 0 to 9. The rate by sex amounted to 90.5% for males and 92.1% for females. The rate by posture was found to be 76.0% for those with unstable necks irrespective of posture. The rate by movement method was 79.7% for those who were unable to move to another place. The rate by convulsion frequency was estimated at 82.8% for those who had at least 10 seizers in the last 2 months. The rate by manual function stood at 73.8% for those whose hands remained clasped or immobile. The rate by mobility impaired was 86.0% for the bed-ridden. The rate by intelligence was relatively high, the lowest being 91% for those with an IQ of 20 or below. The rate by feeding method was estimated at 65.5% for those with tube feeding.
3.The influence of those factors on prognosis was evaluated by means of Cox's proportional hazard model. Covariates found to be significantly correlative included : sex ; movement method ; feeding type ; morbidity impairment ; manual function ; age.
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