2000 Fiscal Year Final Research Report Summary
PRES1 CONTRIBUTES IN HEPATOCARCINOGENESIS IN PATIENTS WITH HBV INFECTION
| Project/Area Number |
11670510
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Gastroenterology
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| Research Institution | KOCHI MEDICAL SCHOOL |
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Principal Investigator |
ONISHI Saburo Kochi Medical School, First Department of Internal Medicine, Professor, 医学部, 教授 (60136380)
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| Co-Investigator(Kenkyū-buntansha) |
SAIBARA Toshiji Kochi Medical School, First Department of Internal Medicine, Research Associate, 医学部・附属病院, 講師 (60145125)
TANIGUCHI Taketoshi Kochi Medical School, Medical Research Center, Associate Professor, 医学部, 助教授 (90127944)
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| Project Period (FY) |
1999 – 2000
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| Keywords | HEPATITIS B VIRUS / HEPATOCELLULAR CARCINOMA / TRANSACTIVATION / CARCINOGENESIS |
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| Research Abstract |
Development of liver fibrosis results in hepatic failure, hepatocellular carcinoma, esophageal varices, and spontaneous peritonitis, which are life-threatening complications in liver cirrhosis. However, patients with chronic hepatitis B virus infection occasionally develop hepatocellular carcinoma in non-cirrhotic liver. Therefore, some unknown mechanisms are assumed to be involved in the process of hepatocarcinogenesis in chronic hepatitis B virus infection. HBX protein has been one of the candidates of such factors. Here we showed for the first time that HBV preS1 is another candidate protein involved in such a mechanism. It affects the feedforward mechanism of EGF-EGFR signalling pathway profoundly involved hepatocarcinogenesis. This novel evidence is important since it may contribute to elucidate the complex mechanism of hepatocarcinogenesis and to find a therapeutic path of hepatocarcinoma in the near future.
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