2001 Fiscal Year Final Research Report Summary

Study of 5-lipoxygenase activating protein gene polymorphism in asthma

Research Project

Project/Area Number	11670570
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Respiratory organ internal medicine
Research Institution	The University of Tokyo
Principal Investigator	KOSHINO Takeshi Tokyo University Department of Assistant Hospital, Respiratory Medicine, The University of Tokyo, Professor, 医学部・附属病院, 助手 (10282659)
Project Period (FY)	1999 – 2001
Keywords	Bronchial Asthma / Disease related gene / 5-lipoxygenase activating protein / FLAP-promoter / Polymorphism / Leukotriene Receptor / Interleukin 16
Research Abstract	We investigated novel polymorphism of asthma associated gene polymorphism. And we found 2 homozygotes of novel alleles in the FLAP promoter polymorphism, which showed 21 and 18 mononucleoacid repeats. There were significant difference of the 21 and 18repeats genotype frequencies between these asthmatics and control subjects. But No association was found between asthmatics and controls in the cys-LT1 receptor gene polymorphism or in the interleukin-16 promoter polymorphism.

(2 results)