2001 Fiscal Year Final Research Report Summary
Molecular immunobiological studies in the pathogenesis of virus induced demyelinating disease
| Project/Area Number |
11670619
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurology
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| Research Institution | Shinshu University |
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Principal Investigator |
KOH Chang-sung Shinshu University, School of Medicine, Associate Professor, 医学部, 助教授 (80143981)
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| Project Period (FY) |
1999 – 2000
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| Keywords | multiple sclerosis / Theiler's virus / demyelination / sex bias |
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| Research Abstract |
We examined the role of sex hormones in the development of Theiler's murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD). Incidence of TMEV-IDD were significantly increased in castrated male BALB/c mice compared to sham operated control male BALB/c mice. Increased incidence of TMEV-IDD in castrated male BALB/c mice were significantly suppressed when the animals were treated with testosterone or 5-a-androstan. TMEV-specific DTH, TNF-a producing ' cells, and INF-gproducing cells were significantly increased in castrated male BALB/c male mice compared to sham operated control male BALB/c mice. RT-PCR revealed significantly increased levels of messenger RNA of TNF-a and INF-g in castrated male BALB/c mice compared to sham operated control male BALB/c mice. Treatment of testosterone or 5-a-androstan reduced increased levels of messenger RNA of TNF-a and INF-g in castrated male BALB/c mice. These findings suggest that testosterone and 5-a-androstan may have suppressive effect in the development of TMEV-IDD, affecting to producing of inflammatory cytokines.
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Research Products
(26 results)
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[Publications] Nohara C, Akiba H, Nakajima A, Inoue A, Koh C-S, Ohshima H, Yagita H, Mizuno Y, Okumura K: "Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand mooclonal antibody. A critical role for OX40 ligand in migration, but not development, of pathogenic Tcells"J Immunol. 166. 2108-2115 (2001)
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[Publications] Nohara,C., Akiba,H., Nakajima,A., Inoue,A., Koh,C-S, Ohshima,H., Yagita,H., Mizuno,Y., Okumura,K.: "Amelioration of experimental autoimmune encephalomyelitis with anti-OX40 ligand mooclonal antibody: A critical role for 0X40 ligand in migration, but not development, of pathogenic T cells."J Immunal. 166. 2108-2115 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Inaba,Y., Ichikawa,M., Inoue,A., Itoh,M., Kyogashima,M., Sekiguchi,Y., Nakamura,S., Komiyama,A., Koh,C-S.: "Plasma thrombin-antithrombin III complexis associated with the severity of experimental autoimmune encephalomyelitis"J Neurol Sci. 185. 89-93 (2001)
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「研究成果報告書概要(欧文)」より
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[Publications] Ichikawa,M., Koh,C-S., Inoue,A., Tsuyusaki,J., Yamazaki,M., Inaba,Y., Sekiguchi,Y., Itoh,M., Yagita,H., Komiyama,A.: "Anti-IL-12 antibody prevents the development and progression of multiple sclerosis like demyelinating disease in NOD mice induced with myelin oligodendrocyte glycoprotein peptide"J Neuroimmunal. 102. 56-66 (2000)
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[Publications] Ichikawa,M., Koh,C-S., Hata,Yukiko, Inaba,Y., Inoue,A., Itoh,M., Ishihara,Y., Bernard,CCA., Komiyama,A.: "IgG subclass switching is associated with the severity of experimental autoimmune encephalomyelitis induced with myelin oligodendrocyte glycoprotein peptide in NOD mice"Cell Immunol. 191. 97-104 (1999)
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[Publications] Inaba,Y., Ichikawa,M., Koh,C-S., Inoue,A., Itoh,M., Kyogashima,M., Komiyama,A.: "Suppression of Experimental Autoimmune Encephalomyelitis by Dermatan Sulfate"Cell Immunol. 198. 96-102 (1999)
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「研究成果報告書概要(欧文)」より
