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2002 Fiscal Year Final Research Report Summary

Effect of Visual or Audition Rhythmic Stimulation on Cognitive Information Processing Speed in patients with Neurodegenerative Diseases.

Research Project

Project/Area Number 11670633
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurology
Research InstitutionYokohama City University

Principal Investigator

KUROIWA Yoshiyuki  Yokohama City Univ. Neurology, Professor, 医学部, 教授 (40135249)

Co-Investigator(Kenkyū-buntansha) SUZUKI Yumi  Yokohama City Univ. Neurology, Assoc. Professor, 医学部, 助教授 (70236024)
YAMADA Hitoshi  Yokohama City Univ. Neurology, Assoc. Professor, 医学部, 助教授 (70240033)
HAEGAWA Osami  Yokohama City Univ. Neurology, Assoc. Professor, 医学部, 助教授 (30237961)
Project Period (FY) 1999 – 2002
KeywordsParkinson's disease / Visual evoked Portends / Auditory-cooked Potentials / Event-related Potential / NSO / P300 / Stimulus-preset Asymolrony / Random rhythm
Research Abstract

Electrophysiological activity was recorded at 7 scalp locations during visual attention task in order to investigate the effect of stimulus-onset asynchrony (SOA) factors ERPs (event-related potentials). We investigated main ERP components and subcomponents derived from subtraction on both constant and random SOA in 9 healthy individualities. Comparted to random condition, the latencies of N1, P2 and P3 of oddball paradigm (OBP) were significantly short, and Negative deflection of N1 amplitude of OBP and positive deflection of P1 and P2 amplitude of simple reaction paradigm (SRP) were significantly large under constant condition. Difference wave form of NA was derived by subtracting the ERPs of SRP from those of the frequent nontarget stimuli of OBP. Difference wave form of N2 was derived by subtracting the ERPs of frequent nontarget stimuli from those of the rare target stimuli in the OBP. Negative deflection of NA amplitude was significantly larger for constant than for tandom condition. No significantly SOA effect was found on N2 component of difference waveform. These results suggest that the visual information processing was fast and increased under constant than random condition. As for the difference waveform, we conclude that pattern recognition processing reflected by NA amplitude was signigicantly influenced by SOA condition, conversely, stimulus classification processing reflected by N2 amplitude was little influenced.

  • Research Products

    (17 results)

All Other

All Publications (17 results)

  • [Publications] Yamazaki T: "Multiple dipole analysis of visual event-related potentials during oddball paradigm"International Congress Series. 1232. 863-870 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamijo K: "Visual event-related potentials during movement imagery and the dipole analysis"Brain Topography. 14. 279-292 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Li, M: "Early sensory information processess are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease"Parkinsonism and Related Disorders. (発表予定). (2003)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Kamitani T: "Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-P"J. Neurol.. 249. 975-982 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamazaki T: "PC-based multiple equivalent current source localization system and its applications"Res. Adv. in Biomedical Eng.. 2. 97-109 (2001)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yamada H: "Anticholinergic drugs : response of parkinsonism not responsive to levodopa"J Neurol Neurosurg Psychiat.. 72. 111-113 (2002)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Wang. L: "Do P1 and N1 evoked by the ERP task reflect primary visual processing in Parkinson's disease?"Document Ophthalmologic. 102. 83-93 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Omoto S: "Modulation of event-related potentials in normal human subjects by visual divided attention to spatial and color factors"Neuroscience Letters. 311. 198-202 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamasaki T: "Multiple dipole analysis of visual event related potentials during oddball paradigm with silent counting"Brain Topography. 13. 161-168 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamazaki T: "PC-based multiple equivalent current dipole source localization system and its applications"Res Adv in Biomedical Eng. 2. 97-110 (2001)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamitani T: "Visual event-related potential changes in two subtypes of multiple system atrophy, MSA-C and MSA-"J Neurol. 249. 975-982 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yamazaki T: "Multiple dipole analysis of visual event related potentials during oddball paradigms."Brain Topography. 14(4). 279-292 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamiji K: "Visual event-related potentials during movement imagery and the dipole analysis."Brain Topography. 14(4). 279-292 (2002)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li M: "Early sensory information processes are enhanced on visual oddball and S1-S2 tasks in Parkinson's disease: a visual event-related potentials study."Parkinsonism and Related Disorders. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamitani T: "Relationship between cerebella size and variation of the reaction time during a visual cognitive task in normal subject"J Neurol. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Li M: "The effect of stimulus-onset asynchrony on human visual event-related potentials during simple and choice reaction paradigms under constant or random conditions study."Neuroscience Letters. in press. (2003)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kamitani T: "Event-related potentials during S1-S2 paradigm in multiple system atrophy: relation to morphologic changes on brain MRI measurements."Parkinsonism and Related Disorders. submitted. (2003)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 2004-04-14  

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