2001 Fiscal Year Annual Research Report
各種神経変性疾患における髄液中3-nitrotyrosineの検討
| Project/Area Number |
11670636
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| Research Institution | Iwate Medical University |
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Principal Investigator |
阿部 隆志 岩手医科大学, 医学部, 助教授 (30202667)
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| Co-Investigator(Kenkyū-buntansha) |
東儀 英夫 岩手医科大学, 医学部, 教授 (90155490)
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| Keywords | 神経変性疾患 / 一酸化窒素 / 3-nitrotyrosine / 脳脊髄液 |
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| Research Abstract |
対象・方法
未治療の弧発性脊髄小脳変性症患者35例(OPCA20例,60.5±7.1歳,CCA15例,63.3±6.7歳)および正常対照群25例(67.0±11.1歳)を対象とし,腰椎穿刺で得られた髄液中の3-nitrotyrosine(3-NT)およびTyrosine(Try)濃度を高速液体クロマトグラフィー・電気化学検出器を用いて測定した.
結果
1.髄液中3-NT濃度(nM)は,正常対照群1.6±0.5、OPCA群1.7±0.9,CCA群1.4±0.9で3群間に有意差を認めなかった.
2.髄液中Try濃度(nM)は,正常対照群6.1±1.0,OPCA群5.9±1.5,CCA群5.8±1.4で3群間に有意差を認めなかった.
3.髄液中3-NT/Try比(×10^<-4>)は,正常対照群2.6±1.0,OPCA群2.9±1.5,CCA群2.5±1.3で3群間に有意差を認めなかった.
結論
弧発性脊髄小脳変性症(OPCA, CCA)の病態に一酸化窒素はとくにperoxnitrite(ONOO^-)が関与することを示唆する所見は得られなかった.
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Research Products
(7 results)
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[Publications] Tohgi Hideo: "Inreased in oxidized NO products and reduction in oxidized glutathione in cerebrospinal fluid from patients with sporadic form of amyotrophic lateral sclerosis"Neuroscience Letters. 260. 204-206 (1999)
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[Publications] Tohgi Hideo: "Remarkable increase in cerebrospinal fluid 3 -ntrotyrosine in patients with sporadic amyotrophic lateral sclerosis increase"Annals of Neurology. 46・2. 129-131 (1999)
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[Publications] Maruyama Wakako: "An endogenous MPTP-like dopaminergic neurotoxin, N-methyl (R) salsolinol, in the cerebrospinal fluid decreases with progressin of Parkinson's disease"Neurosciense Letters. 262. 13-16 (1999)
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[Publications] Tohgi Hideo: "Alterations of 3-nitrotyrosine concentration in the cerebrospinal fluid during aging and in patients with Alzheimer's disease"Neurosciense Letters. 269. 52-54 (1999)
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[Publications] Abe Takashi: "Reduction in asymmetrical dimethylarginine, an endogenousnitric oxide synthase inhibitor, in the cerebrospinal fluid during aging and in patients with Alzheimer's disease"Neuroscience Letters. 312. 177-179 (2001)
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[Publications] Tohgi Hideo: "Symptomatic characteristics of parkinsonism and the width of substantia nigra pars compacta on MRI according to ischemic changes in the putamen and cerebral white matter : implications for the diagnosis of vascular parkinsonism"European Neurology. 46. 1-10 (2001)
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[Publications] 阿部 隆志: "パーキンソン病 -診断と治療-"金原出版. 10 (2000)
