2000 Fiscal Year Final Research Report Summary

The clarification of pathology of allergic Reactions to gelatin-containing vaccine.

Research Project

Project/Area Number	11670771
Research Category	Grant-in-Aid for Scientific Research (C)
Allocation Type	Single-year Grants
Section	一般
Research Field	Pediatrics
Research Institution	Sapporo Medical University
Principal Investigator	TSUTSUMI Hiroyuki Department of Pediatrics, Sapporo Medical University School of Medicine, Assistant Professor, 医学部, 講師 (80217348)
Project Period (FY)	1999 – 2000
Keywords	gelatin / gelatin allergy / Th1 / Th2
Research Abstract	We investigated the characteristics of T lymphocytes from patients allergic to gelatin-containing vaccine by secondary in vitro stimulation of circulating mononuclear cells with gelatin. Patients with an immediate reaction all had gelatin-specific IgE antibody, whereas others did not. Lymphocytes from subjects with nonimmediate-type reactions generally expressed very weak or sometimes no IFN-γ, IL-2 , or IL-13 genes and especially no IL-4 gene. On the other hand, the lymphocytes of subjects with immediate-type reactions significantly expressed not only IL-4 and IL-13 but also IFN-γ and IL-2 mRNA.These suggest that both gelatin-specific Th2 and Th1 responses are involved in the pathogenesis of the immediate reaction to gelatin. The gelatin-specific IL-4 and/or IL-13 responses consistently observed in patients with an immediate reaction may be associated with the production of gelatin-specific IgE antibody.

(4 results)