2001 Fiscal Year Final Research Report Summary
THE DEVELOPMENT OF STENT GRAFT FOR AORTIC ANEURYSM ; STUDY FOR POROSITY OF GRAFT
| Project/Area Number |
11670909
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Nara Medical University |
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Principal Investigator |
KICHIKAWA Kimihiko NARA MEDICAL UNIVERSITY, MEDICAL DEPARTMENT, ASSOCIATE PROFESSOR, 医学部, 助教授 (10161506)
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| Co-Investigator(Kenkyū-buntansha) |
SAKAGUCHI Shoji NARA MEDICAL UNIVERSITY, MEDICAL DEPARTMENT, RESEARCH PROFESSOR, 医学部, 助手 (00316077)
KUBOTA Yasushi NARA MEDICAL UNIVERSITY, MEDICAL DEPARTMENT, RESEARCH PROFESSOR, 医学部, 助手 (20275332)
UCHIDA Hideo NARA MEDICAL UNIVERSITY, MEDICAL DEPARTMENT, PROFESSOR, 医学部, 教授 (90028481)
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| Project Period (FY) |
1999 – 2000
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| Keywords | STENTGRAFT / AORTIC ANEURYSM / POROSITY |
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| Research Abstract |
We made the stent graft, which was constructed from a custom-made spiral Z-stent covered with a thin-wall woven Dacron with a porosity of 200 and 1000 ml/cm2/min. The proximal and distal 1cm of the stent graft was bare to prevent migration. We compared macro- and micro-scopical findings of these stent grafts in canine aorta at 6 months. In canine infrarenal abdominal aorta, the stent grafts were correctly placed at the intended site without migration and good patency was obtained immediately after procedure. The angiogram at 6 months showed no intraluminal narrowing and lumbar artery was occluded. IVUS demonstrated good apposition of stent graft to arterial wall and intimal thickening was minimal. Microscopic inspection reveal that the stent graft was covered with thin neointima without any foreign body reaction. There was no difference about these findings between two kinds of stent graft. In the model of aneurysm, DSA was performed with stent graft (with a porosity of 200 and 1000 ml/cm2/min). Pressure was measured within stent graft and anurysmal sac. DSA showed endoleak with stent graft of 1000 porosity. There was no significant difference between two kinds stent graft about pressure gradient. It was suggested that stent with 200 porosity was more desirable to prevent initial endoleak, however, long term follow up was needed in clinical case to detect the change of aneurysm diameter after stent graft placement.
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