2001 Fiscal Year Final Research Report Summary
Study of Neural Network in the Model of Methamphetamine-Psychosis using Antisense Ologonucleotides Method
| Project/Area Number |
11670925
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Psychiatric science
|
|---|
| Research Institution | HOKKAIDO UNIVERSITY |
|---|
Principal Investigator |
ABEKAWA Tomohiro Hokkaido Univ., Grad. School of Medicine, Assistant Professor, 医学部・附属病院, 助手 (80301901)
|
|---|
| Project Period (FY) |
1999 – 2001
|
| Keywords | METHAMPHETAMINE / PHENCYCLIDINE / SENSITIZATION / GLUTAMATE / GABA / MS-153 |
|---|
| Research Abstract |
A novel compound, MS-153, which has an ability to enhance glutamate uptake and inhibit glutamate release, blocked the development of behavioral sensitization to locomotion-inducing effect of methamphetamine. Further, MS-153 blocked the development of sensitization not only to locomotion-but also stereotypy-inducing effect of phencyclidine. These results indicate that methamphetamine- or phencyclidine-inducing enhancement of glutamatergic neurotransmission can play an important role for developing behavioral sensitization to methamphetamine, or phencyclidine, respectively.
|
