2000 Fiscal Year Final Research Report Summary
Molecular mechanism in metastasis and proliferation of lymphoma cells
| Project/Area Number |
11670997
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hematology
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| Research Institution | Osaka University |
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Principal Investigator |
NISHIURA Tetsuo Osaka University Graduate School of Medicine , Assistant professor, 医学系研究科, 助手 (00252669)
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| Co-Investigator(Kenkyū-buntansha) |
OKAJIMA Yu Osaka University Hospital, Medical Staff, 医学部・附属病院, 医員
YOSHIDA Hitoshi Osaka University Hospital, Medical Staff, 医学部・附属病院, 医員
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| Project Period (FY) |
1999 – 2000
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| Keywords | integrin / malignant lymphoma / CD47 / integrin associated protein / CDC42 / metastasis / Rac1 / small G protein |
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| Research Abstract |
Lymphoma cells proliferate predominantly in lymph node. Metastatic potential of lymphoma cells contributes to determine prognosis of lymphoma patients. The molecular mechanisms underlying metastatic potentialof lymphoma cells has not yet been fully elucidated. Cell migration plays a key role in metastatic potential in lymphoma cells. In this study, we have focused integrin associated proteins (IAP)/CD47 in B cell malignancies, and have demonstrated that following results,
1) Anti-CD47 monoclonal antibody, B6H12, produced signals to promote polarization with lamellipodia in B cell lines.
2) B6H12 acivate migratory activity of BALL cells to fibronectin.
3) Dominant negative form of CDC42 completely blocked B6h12 induced morphologic and functional changes.
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