2000 Fiscal Year Final Research Report Summary
Analysis of association between anorexia nervosa and neuropeptide or amine receptor genes.
| Project/Area Number |
11671098
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Endocrinology
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| Research Institution | Tokyo Women's Medical University |
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Principal Investigator |
SUZUKI Mari School of Medicine, Instructor, 医学部, 助手 (90128140)
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| Project Period (FY) |
1999 – 2000
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| Keywords | Anorexia nervosa / Corticotropin-releasing factor receptor gene / RFLP / PCR |
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| Research Abstract |
The hypersecretion of endogenous Corticotropin-releasing factor (CRF) is present in patients with anorexia nervosa and is supposed to be related to its pathogenesis.
To examine genetic factors that may play a significant role in susceptibility to anorexia nervosa (AN), CRF receptor type 1 and type 2 genes were analyzed in 15 AN patients with a family history of this disease. Any polymorphism of each receptor was not found.
PCR products of exons and boundary regions of CRFR1 as well as CRFR2 were sequenced. However, no base substitution was found.
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