2001 Fiscal Year Final Research Report Summary
The inhibitory effect of Leptin on the unresponsiveness to glucose induced by high glucose consentrat ion in isolated islets form rats
| Project/Area Number |
11671139
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Metabolomics
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| Research Institution | Yokohama City University College of Nursing |
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Principal Investigator |
EGAWA Masato Yokohama City University College of Nursing, Dept. of Physiopathology, Proffer, 病態学, 教授 (40232938)
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| Project Period (FY) |
1999 – 2000
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| Keywords | leptin / islets / Glucose / glucose toxieity / Rats / mice / マウス |
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| Research Abstract |
It is reported that Leptin has the opening action in ATP dependence K + channel of pancreatic beta cell (Diabetes.46 : 1087(1997).). Since Diazoxide the opener of ATP dependence K + channel, suppresses "the sugar unresponsiveness induced by hyperglyceraia", we examined the possibility that the endogenic leptin also suppress the unresponsiveness induced by hyperglyceraia in islets isolated from rats and mice.
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Research Products
(2 results)
