2000 Fiscal Year Final Research Report Summary
Trial of donor specific immunosuppression with BrdU using rat liver transplant model
| Project/Area Number |
11671155
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
General surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
TERAMOTO Kenichi Tokyo Medical and Dental University, Surgery, Associate Professor, 大学院・医歯学総合研究科, 助教授 (80197813)
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| Project Period (FY) |
1999 – 2000
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| Keywords | liver transplantation / organ rejection / bromodeoxyuridine |
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| Research Abstract |
Abrogation of organ rejection by BrdU and 5FU was examined using rat liver transplant model. ACI rat liver was transplanted into LEW rat orthotopically. Without treatment the recipient was died within 11days. With the treatnent of intravenous injection of BrdU and 5FU surviva days was 17 days. However, with the treatment of intraperitoneal contimuous injection of BrdU and 5FU the recioent lived for 45 days. Histrogical findings revealed no rejection in the treatment group. On the other hand in the no treatment group, severe cell infiltration was recognized.
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