2002 Fiscal Year Final Research Report Summary
Development of implantable cardiomyostimulator for cardiomyoplasty and rapid ventricular pacing
| Project/Area Number |
11671312
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Thoracic surgery
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| Research Institution | Shinshu University |
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Principal Investigator |
AMANO Jun Shinshu University, Surgery, Professor, 医学部・第二外科, 教授 (20138283)
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| Co-Investigator(Kenkyū-buntansha) |
TAKANO Tamaki Shinshu University, Hospital, Instructor, 医学部附属病院, 助手 (00334912)
KITAHARA Hiroto Shinshu University, Surgery, Instructor, 医学部・第二外科, 助手 (40285599)
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| Project Period (FY) |
1999 – 2002
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| Keywords | Cardiomyoplasty / Implantable cardiomyostimulator / Rapid pacing / Heart failure model |
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| Research Abstract |
We developed an implantable cardiomyostimulator for cardiomyoplasty and rapid ventricular pacing through Grant-In-Aid research. This stimulator is now commercially available and used by research institutions for animal experiment.
The stimulator composed of a main electronic circuit, a lithium-ion battery, an ABS resin housing and connection ports. It generates 0 to 3.6 V of pulse at 250 to 350 bpm in rapid pacing mode. A bi-directional programmer can set these variable parameters pericutaneously even after implantation.
We performed long-term animal experiments using 8 beagles. The applied pacing was 3.6 V at 256 bpm on right ventricle, and pacing time was 4 weeks. After the pacing, the animals had significant heart failure. They showed ascites and body weight gain. Cardiac output decreased, and right and left atrial pressure increased. Plasma rennin activity, aldosterone, atrial natriuretic peptide also increased. These results showed feasibility of the stimulator for inducing cardiac failure in animal experiment. The electronic circuit is able to re-use for the animal experiment because no damaged was observed in6 of 8 simulators. The 2 stimulators stopped due to water flood and condenser defect. This showed endurance of the stimulator for long-term experiment.
We would continue the experiment to evaluate cardiac function on cardiomyoplasty after the stimulator induces heart failure.
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